Association of Plantar Fasciitis with Lipid Profile and Glucose Level: A Case-Control Study

Abstract

Background Hyperlipidemia is associated with tendon disorders and biomechanical changes through tissue deposition. In the present study, we seek the relation of plantar fasciitis (PF) with lipid profile parameters and fasting blood sugar (FBS) levels. Methods In a case-control study, we enrolled 68 patients with a clinical diagnosis of PF in the case group and 136 individuals without PF in the control group. Patients’ height, weight, body mass index (BMI), FBS, lipid profile including low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol, and triglyceride (TG) laboratory tests were also checked as the main study variables to be compared between the two groups. The mean difference of each variable between the two case and control groups was tested using an independent t-test. Correlation coefficient analyses were used to calculate the correlation of patients’ BMI with lipid profile and FBS levels to evaluate the BMI variable as a confounder. Results Patients with PF had higher levels of total cholesterol (p=0.001), LDL (P= 0.004), and TG (P=0.02). HDL (P=0.13) and FBS (P=0.24) levels did not differ between two groups. Odds ratio calculation showed that patients with serum levels of LDL >130 mg/dl and total cholesterol > 200 mg/dl were 3.7 and 1.8 times more likely to develop PF, respectively. We found no association between lipid profile parameters and BMI in either of the two groups. Conclusions Our findings show higher levels of serum lipid profile parameters in patients with PF. Thus, it supports the modification of LDL, TC, TG, and glucose levels when managing PF. Trial Registration: The study does not include intervention.

Corelation of hypothyroidism and dyslipidemias with plantar fasciitis in Indian population

“…Several studies have already established the role of hyperlipidemia in patients with PF. 9 To the best of our knowledge, there is no documented evidence to suggest a potential relationship between PF and hypothyroidism. This paper evaluates the relation of thyroid disorders and hyperlipdemia in Indian patients.…”

“…10 Research has shown that individuals with hyperlipidemia may be more likely to develop PF, and that the condition may be more severe in these individuals. 9 This may be due to the fact that hyperlipidemia can lead to changes in the body's inflammatory response, which can exacerbate the inflammation of the plantar fascia. Additionally, hyperlipidemia can lead to the deposition of fatty acids and cholesterol in the blood vessels that supply the plantar fascia, which can lead to reduced blood flow and further contribute to the development of PF.…”