Association of Oxidative Stress and Production of Inflammatory Mediators Matrix Metalloproteinase-9 and Interleukin 6: Systemic Events in Radicular Cysts

Abstract

Background Matrix metalloproteinase-9 (MMP-9) and antioxidants are associated with the pathogenesis of cysts and may initiate and sustain the formation of new capillaries. Objective The objective of this study was to determine the association of oxidative stress and the production of inflammatory mediators MMP-9 and interleukin 6 (IL-6) in systemic events in radicular cyst growth.

Reduction of NrF2 as coadjuvant during the development of persistent periapical lesions

“…Our results were contradictory in this aspect, to reported by Malik et al . (2020) since the levels of SOD and GPx (57.934 and 102.9 U/mL, respectively) were superior in PPL patients and they reported a significant decrement in patients compared to controls in levels of SOD (0.03 and 0.11 nmol/ml, respectively) and GPx (5.88 and 7.87 nmol/ml, respectively) ( 9 ) Probably by MDA may reduce the activity of glutathione peroxidase in periapical granulomas, as it has been reported by Ayala et al . ( 10 ).…”

“…When polyunsaturated fatty acids are oxidized by ROS, malondialdehyde (MDA) is produced upon fatty acid decomposition; thus, measurement of MDA has been used as an indicator of LPO ( 21 ). Oxidative stress has an important role in the pathogenesis during PPL formation, for example in a radicular cyst ( 9 ). The levels of lipid peroxidation by MDA analysis have been reported in several investigations as Franco C. (2017), in an experimental study were reported a significant elevation in the levels of MDA in periapical lessons ( 22 ).…”

“…Similarly, our results are contundents with this author and others as showed by Marton IJ, (1993) that indicate an elevation of MDA (805±365 nmol/g protein) in periapical granuloma samples with respect to controls (469 + 202 nmol/ g protein) ( 23 ) or Malik et al . (2020), that report an increment of levels of MDA in patients with radicular cyst as compared to control group (4.11 and 1.37 nmol/ml, respectively) ( 9 ). All these results indicate that reactive oxygen radicals cause biologically significant lipid peroxidation in PPL.…”

“…( 10 ). The reduced activity of SOD and GPx may further the development of the lesion, resulting in oxidative stress ( 9 ). However, it should be noted that these results were carried out in serum and ours in dental tissue samples.…”

“…Oxidative stress (free radicals generation) is involved in the pathogenesis of a variety of inflammatory disorders like periapical lesions, in particular the reactive oxygen species (ROS) produced by phagocytic cells in response to infectious process represent an important host defense mechanism, nevertheless in excess results in tissue injury and bond destruction ( 8 ) by activation of matrix metalloproteinases (MMPs) and inflammatory mediators through damage to deoxyribonucleic acids, proteins, lipids, and membranes ( 9 ). However, antioxidants present an opposing free radical action by both non-enzymatic and enzymatic reactions.…”