2016
DOI: 10.18632/aging.101137 View full text |Buy / Rent full text
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Abstract: In order to investigate the influence of season and month of birth on the risk of neovascular age-related macular degeneration (n-AMD) in Italy, we evaluated the month birth and sex of all patients, recorded in the anti-vascular endothelial growth factor (VEGF) monitoring registry of the Italian Medicines Agency, born between 1925–1944, who received intravitreal anti-VEGF injections for n-AMD between January 1, 2013 and July 29, 2015. The numbers of all births in Italy in the same years, extracted from the Ita… Show more

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“…AMD is the result of a complex interaction between environmental factors and genetic. Smoking is the most consistently identified modifiable risk factor, but dietary factors, solar insolation, and season of birth may also affect AMD incidence and progression [5,6]. The pathogenesis of neovascular AMD has long been debated but at present it remains not fully elucidated.…”
Section: Introductionmentioning
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“…AMD is the result of a complex interaction between environmental factors and genetic. Smoking is the most consistently identified modifiable risk factor, but dietary factors, solar insolation, and season of birth may also affect AMD incidence and progression [5,6]. The pathogenesis of neovascular AMD has long been debated but at present it remains not fully elucidated.…”
Section: Introductionmentioning
“…Some scholars correlate the season of birth with Vitamin –D exposure [ 61 ]. Moreover; the temperature level at the time of birth season affects the infants' anthropometry due to disruption of Vitamin D synthesis [ 62 ].Further more birth season had a significant correlation with cardiovascular, mental, and neurovascular diseases [ 63 , 64 ].…”
Section: Discussionmentioning
“…It is widely recognized that VEGF is a key mediator of angiogenesis and an effective biological target for patients with metastatic colorectal cancer, and its overexpression can accelerate tumor progression and metastatic spread of colorectal cancer [ 27 , 28 ]. Also, VEGF signaling cascade can lead to the suppression of nitric oxide production in endothelial cells, which, in turn, results in vasoconstriction and decrease in sodium renal excretion, with an ultimate end point of hypertension [ 29 - 32 ]. Bevacizumab is targeted at VEGF and blocks it from binding to its receptors, therefore impairing angiogenesis and detaining tumor growth and metastasis [ 33 , 34 ].…”
Section: Discussionmentioning