Multiple primary malignant tumors first were described by Billrath in 1889 (1). Until the extensive and detailed study of Warren and Gates (2) in 1932, multiple primary tumors were considered medical curiosities.The clinical problems and special medical aspects of these patiente account for the numerous case reporte and clinical series in the literature (3-10). It is obvious that regardless of the siae and thoroughness of a olinical series, there is always a possibility of error if no postmortem examination is made.
MATERIALS AND METHODSThe records of 16,444 postmortem examinations inclusive) on file in the Department of Pathology at Cleveland Metropolitan General Hospital were reviewed. At least 1 malignant tumor wm recorded in 3,321 autopsy protocols. More than 1 primary malignant neoplasm was found in 177 mes. All available gross and microscopic findings were analyzed. Hospital records and the microscopic slides were reviewed.