Association of Monocyte-To-High Density Lipoprotein-Cholesterol Ratio with Peripheral Neuropathy in Patients with Type Ii Diabetes Mellitus

Canpolat, Asena Gökçay; Emral, Rıfat; Keskin, Çağlar; Canlar, Şule; Şahi̇n, Mustafa; Çorapçıoğlu, Demet

doi:10.2217/bmm-2018-0451

Cited by 14 publications

(5 citation statements)

References 32 publications

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“…Most recently, considering the pro-inflammatory properties of monocytes and the anti-inflammatory properties of high-density lipoprotein (HDL), the ratio of monocyte to HDL-cholesterol (MHR) has been viewed as a novel systemic inflammatory marker used in clinical applications. Some studies show that MHR is associated with metabolic syndrome ( 15 ), acute coronary syndrome ( 16 ), and T2DM ( 17 , 18 ). MHR has been shown to be an independent predictor of carotid artery disease in acute ischemic stroke ( 19 ) and diabetic retinopathy in T2DM patients ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic performance of novel inflammatory biomarkers based on ratios of laboratory indicators for nonalcoholic fatty liver disease

Zhao

Xia

et al. 2022

Front. Endocrinol.

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IntroductionThere is few effective biomarkers for diagnosing nonalcoholic fatty liver disease (NAFLD) in clinical practice. This study was aimed to investigate the predictive ability of novel inflammatory biomarkers, including the monocyte to high-density lipoprotein cholesterol ratio (MHR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR), for NAFLD.MethodsA total of 4465 outpatients diagnosed with NAFLD and 3683 healthy controls were enrolled between May 2016 and November 2021 from the West China Hospital of Sichuan University, and anthropometric and laboratory examination data were collected. The two-sample Mann-Whitney U test and binary logistic regression analysis were used to evaluate the correlations between four inflammatory biomarkers and NAFLD. The areas under the curves (AUCs) of receiver operating characteristic were used to evaluate their predictive ability for NAFLD.ResultsThe MHR, NLR and LMR were higher in patients with NAFLD than in healthy controls (P<0.001), whereas the PLR was remarkably lower (P<0.001). The OR values of the MHR, NLR, PLR, and LMR were 1.599 (1.543-1.658), 1.250 (1.186-1.317), 0.987(0.986-0.988) and 1.111(1.083-1.139), respectively(P<0.001). After adjusting for confounding factors, MHR was still the most relevant risk factor for NAFLD compared with other inflammatory markers (P<0.001). The AUCs of the MHR, NLR, PLR, and LMR were as follows: 0.663 (0.651-0.675), 0.524 (0.512-0.537), 0.329 (0.318-0.341), and 0.543 (0.530-0.555), respectively (P<0.001). Furthermore, the diagnostic model combining the MHR with alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglycerides, fasting blood glucose, creatinine, uric acid, and body mass index had the best AUC of 0.931 (0.925-0.936).ConclusionsMHR was superior to NLR, PLR and LMR as an inflammatory biomarker in the prediction of NAFLD. When combined with relevant laboratory parameters, the MHR may improve the clinical noninvasive diagnosis of NAFLD.

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Section: Introductionmentioning

confidence: 99%

Diagnostic performance of novel inflammatory biomarkers based on ratios of laboratory indicators for nonalcoholic fatty liver disease

Zhao

Xia

et al. 2022

Front. Endocrinol.

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“…Therefore, the monocyte count–to–HDL-C ratio (MHR) can reflect the inflammatory status and is related to the development of disease associated with chronic inflammation. The MHR has been found to be associated with the occurrence and prognosis of cardiovascular diseases (CVDs), diabetic nephropathy and diabetic peripheral neuropathy ( 14 – 17 ). However, to the best of our knowledge, there are a few studies with small sample size that evaluated the associations of the MHR with DR and got contradictory conclusion ( 18 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

Association of the Monocyte–to–High-Density Lipoprotein Cholesterol Ratio With Diabetic Retinopathy

Tang

Tan

Yang

et al. 2021

Front. Cardiovasc. Med.

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Background: Chronic inflammation in type 2 diabetes mellitus (T2DM) is an essential contributor to the development of diabetic retinopathy (DR). The monocyte–to–high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel and simple measure related to inflammatory and oxidative stress status. However, little is known regarding the role of the MHR in evaluating the development of DR.Methods: A total of 771 patients with T2DM and 607 healthy controls were enrolled in this cross-sectional study. MHR determination and eye examination were performed. The association of MHR with the prevalence of DR in T2DM patients was analyzed.Results: The MHR in patients with DR was significantly higher than that in both non-DR diabetic patients (P < 0.05) and healthy controls (P < 0.01). No significance was observed in the MHR of different DR severity grades. Moreover, the MHR was similar between patients with non-macular oedema and those with macular oedema. Logistic regression analysis demonstrated that MHR was independently associated with the prevalence of DR in diabetic patients [odds ratio (OR) = 1.438, 95% confidence interval (CI): 1.249–1.655, P < 0.01]. After additional stratification by HbA1c level and diabetic duration, the MHR was still independently associated with the prevalence of DR.Conclusions: Our study suggests that the MHR can be used as a marker to indicate the prevalence of DR in patients with T2DM.

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“…Monocytes and macrophages aggregate at the site of inflammation and release inflammatory cytokines, leading to acute vascular inflammation. This damages the endothelial cells of the blood vessels and promotes thrombus formation [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Construction of a nomogram model for deep vein thrombosis in patients with tibial plateau fracture based on the Systemic Inflammatory Response Index

Ling,

Li,

Huang

et al. 2024

BMC Musculoskelet Disord

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Background In recent years, the incidence of tibial plateau fracture has been on the rise, predominantly affecting the elderly population. Deep vein thrombosis may lead to poor prognosis in patients. the Systemic Inflammatory Response Index are novel biomarkers of inflammation, and this study aims to verify their predictive effect and construct the nomogram model. Method This study used binary logistic regression analysis to predict the predictive effect of SIRI on the occurrence of DVT in tibial plateau fracture patients. And use R studio to construct nomogram model. Result The results showed that NC (7.036 [3.516, 14.080], p < 0.001), LYM (0.507 [0.265, 0.969], p = 0.04), and SIRI (2.090 [1.044, 4.182], p = 0.037) were independent predictive factors for DVT. The nomogram demonstrated good predictive performance with small errors in both the training and validation groups, and most clinical patients could benefit from them. Conclusion The nomogram constructed based on SIRI can assist clinicians in early assessment of the probability of DVT occurrence.

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Association of Monocyte-To-High Density Lipoprotein-Cholesterol Ratio with Peripheral Neuropathy in Patients with Type Ii Diabetes Mellitus

Cited by 14 publications

References 32 publications

Diagnostic performance of novel inflammatory biomarkers based on ratios of laboratory indicators for nonalcoholic fatty liver disease

Diagnostic performance of novel inflammatory biomarkers based on ratios of laboratory indicators for nonalcoholic fatty liver disease

Association of the Monocyte–to–High-Density Lipoprotein Cholesterol Ratio With Diabetic Retinopathy

Construction of a nomogram model for deep vein thrombosis in patients with tibial plateau fracture based on the Systemic Inflammatory Response Index

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