Association of miR-34b/c rs4938723 and TP53 Arg72Pro Polymorphisms with Neuroblastoma Susceptibility: Evidence from Seven Centers

Li, Le; Zhu, Jinhong; Lu, Tongyi; Liu, Wei; Tang, Jue; Zhang, Jiao; Wang, Yizhen; Li, Yong; Li, Suhong; Zhou, Haixia; Xia, Huimin; He, Jing; Cheng, Jiwen

doi:10.1016/j.tranon.2019.06.008

Cited by 8 publications

(6 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, the association between miR34b/c and Wilms tumor susceptibility has not been investigated. miR34b/c has been shown to be intimately connected to the development and prognosis of a variety of tumors, including gastric cancer, bladder cancer, pancreatic cancer, ovarian cancer, prostate cancer, hepatocellular carcinoma, neuroblastoma and many others [31][32][33][34][35]. In our previous study, we found that miR34b/c rs4938723 T>C polymorphism has a protective effect on neuroblastoma [36].…”

Section: Discussionmentioning

confidence: 90%

The association of miR34b/c and TP53 gene polymorphisms with Wilms tumor risk in Chinese children

et al. 2020

Self Cite

View full text Add to dashboard Cite

Wilms tumor is the most common pediatric malignancy in the kidney. The miR34b/c is a downstream target gene of the transcription factor p53. The important role of TP53 mutations, the methylation of miR34b/c, and the interaction between these two molecules in tumorigenesis have been well documented. Due to the biological connection between p53 and miR34b/c, in the present study, we investigated the association between polymorphisms in these two molecules and Wilms tumor susceptibility through genotyping two important functional polymorphisms (miR34b/c rs4938723 T>C and TP53 rs1042522 C>G) in 183 cases and 603 controls. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) derived from the logistic regression analysis were used to assess the correlation of miR34b/c rs4938723 and TP53 rs1042522 polymorphisms with Wilms tumor risk. Our results indicated that the association of miR34b/c rs4938723 and TP53 rs1042522 polymorphisms with Wilms tumor susceptibility was not statistically significant. Stratified analysis by age, gender, and clinical stage, as well as combined effect analysis were also performed, yet, no significant association was found. In conclusion, our study indicated a lack of association between the two selected polymorphisms and Wilms tumor susceptibility. Our findings need to be verified in studies with larger sample size in the future.

show abstract

Section: Discussionmentioning

confidence: 90%

The association of miR34b/c and TP53 gene polymorphisms with Wilms tumor risk in Chinese children

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…In several existing studies, variations in TP53 have been significantly associated with susceptibility to various pediatric tumors. Of which, TP53 Pro/Pro genotype was associated with increased susceptibility to acute lymphoblastic leukemia in Caucasian children [ 48 ], TP53 rs1042522 CG/GG genotype had a significantly increased risk of Wilms tumor in children under 18 months of age [ 49 ], and TP53 rs1042522 CG/GG genotype was associated with reduced susceptibility to neuroblastoma [ 50 ]. Meanwhile, mutations in TP53 affect tumor treatment and prognosis.…”

Section: Discussionmentioning

confidence: 99%

Association of TP53 rs1042522 C>G Polymorphism with Glioma Risk in Chinese Children

Liao

Zhu

et al. 2022

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Glioma is the most common intracranial malignancy. TP53 is a crucial tumor suppressor gene that plays an essential regulatory role in cell growth, apoptosis, and DNA repair. The TP53 rs1042522 C>G polymorphism has been reported to be strongly associated with various tumor risks. To assess the TP53 rs1042522 C>G polymorphism with glioma risk in Chinese children, we determined the genotypes of the TP53 rs1042522 C>G polymorphism in 171 glioma patients and 228 cancer-free controls by Taqman assay. We assessed the association of the polymorphism with glioma risk using odds ratio (OR) and 95% confidence interval (CI) generated by logistic regression models. We also performed stratified analyses by age, gender, tumor subtypes, and clinical stages, but no significant association was detected between TP53 rs1042522 C>G polymorphism and childhood glioma risk. These results suggest that the TP53 rs1042522 C>G polymorphism is not associated with glioma risk in Chinese children. Subsequent studies with a larger sample size are needed to validate our results.

show abstract

“… 44 This polymorphism was subsequently found to be associated with the risk of developing neuroblastoma and Wilms’ tumor but not hepatoblastoma among Chinese children. 19 , 21 , 34 However, there remains a lack of valuable evidence depicting the association between the polymorphism and the integrated risk of pediatric malignant abdominal solid tumors. To the best of our knowledge, only one study has investigated this particular association by genotyping 101 pediatric solid tumors samples and 202 controls; Borbora et al identified an SNP pair composing of TP53 rs1042522 and p21 cip1 rs1059234 that had a significant impact on the risk of developing pediatric solid tumors.…”

Section: Discussionmentioning

confidence: 99%

“… 16 This gene encodes a 393 amino-acid–long protein that is critical for regulating the cell cycle and executing tumor suppressing functions by orchestrating of the transcriptional activation of tumor-associated genes involved in apoptosis, maintenance of genetic stability, and angiogenesis. 17 - 19 Alterations in this gene have been extensively studied in a variety of human malignancies, including pediatric malignant solid tumors. 20 The fact that the Single Nucleotide Polymorphism Database hosts information regarding >1000 TP53 single nucleotide polymorphisms (SNPs) supports the highly polymorphic nature of this gene.…”

Section: Introductionmentioning

confidence: 99%

Association Between Arg72Pro Polymorphism in TP53 and Malignant Abdominal Solid Tumor Risk in Hunan Children

Liu

Xiao

et al. 2021

Cancer Control

Self Cite

View full text Add to dashboard Cite

Pediatric solid tumors are heterogeneous and comprise various histological subtypes. TP53, a tumor suppressor, orchestrates the transcriptional activation of anti-cancer genes. The gene coding for this protein is highly polymorphic, and its mutations are associated with cancer development. The Arg72Pro polymorphism in TP53 has been associated with susceptibility to various types of cancer. Here, in this hospital-based study, we evaluated the association of this polymorphism with susceptibility toward malignant abdominal solid tumors in children in the Hunan province of China. We enrolled 162 patients with neuroblastoma, 60 patients with Wilms’ tumor, and 28 patients with hepatoblastoma as well as 270 controls. Genotypes were determined using a TaqMan assay, and the strength of the association was assessed using an odds ratio, within a 95% confidence interval identified using logistic regression models. Our results showed that the Arg72Pro polymorphism did not exhibit significant association with susceptibility toward pediatric malignant abdominal solid tumors. Stratification analysis revealed that this polymorphism exerts weak sex- and age-specific effects on Wilms’ tumor and hepatoblastoma susceptibility, respectively. Overall, our results indicate that the Arg72Pro polymorphism may have a marginal effect on susceptibility toward pediatric malignant abdominal solid tumors in Hunan, and this finding warrants further confirmation.

show abstract

Association of miR-34b/c rs4938723 and TP53 Arg72Pro Polymorphisms with Neuroblastoma Susceptibility: Evidence from Seven Centers

Cited by 8 publications

References 54 publications

The association of miR34b/c and TP53 gene polymorphisms with Wilms tumor risk in Chinese children

The association of miR34b/c and TP53 gene polymorphisms with Wilms tumor risk in Chinese children

Association of TP53 rs1042522 C>G Polymorphism with Glioma Risk in Chinese Children

Association Between Arg72Pro Polymorphism in TP53 and Malignant Abdominal Solid Tumor Risk in Hunan Children

Contact Info

Product

Resources

About