Association of miR-196a2 rs11614913 and miR-499 rs3746444 polymorphisms with cancer risk: a meta-analysis

Yan, Wanjun; Gao, Xiaoyan; Zhang, Shuqun

doi:10.18632/oncotarget.22547

Cited by 27 publications

(25 citation statements)

References 84 publications

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“…All four miRNA gene variant associations noteworthy to detect an OR of 1.1 that were also noteworthy (FPRP < 0.2) were included in these 16 comparisons. The other 12 comparisons were miR‐196a2/rs11614913 T vs. C (OR, 1.21; P < .0001); miR‐27a/rs895819 GG vs. AA + AG (OR, 1.49, P < .001) and colorectal cancer ; miR‐196a2/rs11614913 C vs. T (OR, 1.40, P < .00001) and oesophageal cancer ; miR‐146a/rs2910164 G vs. C (OR, 1.15, P < .001); miR‐196a2/rs11614913 T vs. C (OR, 0.77, P < .00001) and gastric cancer ; miR‐146a/rs2910164 C vs. G (OR, 1.19, P < .001) and bladder cancer ; miR‐499/rs3746444 homozygous model (OR, 1.64, P < .001) and breast cancer ; miR‐146a/rs2910164 CC vs. GG + GC (OR, 0.52, P < .001); miR‐499/rs3746444 (OR, 2.07, P < .001) and cervical cancer ; miR‐499/rs3746444 GA vs. AA (OR, 1.60, P < .001) and prostate cancer ; miR‐146a/rs2910164 CC vs. GG (OR, 1.28, P < .001) and lung cancer ; and miR‐499/rs3746444 G vs. A (OR, 1.57, P < .001) and oral squamous cell cancer …”

Section: Resultsmentioning

confidence: 99%

Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta‐analysis

Park

Jeong

Lee

et al. 2020

Eur J Clin Investigation

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Background Cancer risk has been associated with certain gene variations in microRNA (miRNA), but conflicting evidence warrants re‐assessing of significant results in meta‐analyses. We summarized published meta‐analyses that assess the associations between miRNA polymorphism and cancers to show the validity of the findings. Method We searched PubMed and investigated the results of meta‐analyses published through November 2018. We re‐assessed the results based on false‐positive report probability (FPRP) to test the noteworthiness of the associations. Results Sixty‐eight miRNA polymorphisms in 45 meta‐analyses associated with cancer were included. Four (7.4%) and sixteen (25.0%) single nucleotide polymorphisms (SNPs) were noteworthy (FPRP < 0.2) at a prior probability of 0.001 for interesting candidate genes and a statistical power to detect an odds ratio (OR) of 1.1 and 1.5, respectively. The four miRNA SNPs noteworthy at an OR of 1.1 were as follows: miR‐146a/rs2910164 Cvs.G; miR‐27a/rs895819 Cvs.T; miR‐423/rs6505162 Cvs.A; and miR‐605/rs2043556 Cvs.T. The 16 SNPs noteworthy at an OR of 1.5 include the four genotype comparisons at an OR of 1.1, and the additional 12 genotype comparisons were as follows: miR‐196a2/rs11614913 Tvs.C; miR‐27a/rs895819 GGvs.AA + AG; miR‐196a2/rs11614913 C vs.T; miR‐146a/rs2910164 Gvs.C; miR‐196a2/rs11614913 Tvs.C; miR‐146a/rs2910164 Cvs.G; miR‐499/rs3746444 homozygous model; miR‐146a/rs2910164 CCvs.GG + GC; miR‐499/rs3746444 TCvs.TT; miR‐499/rs3746444 GAvs.AA; miR‐146a/rs2910164 CCvs.GG; and miR‐499/rs3746444 Gvs.A. No association was noteworthy at a prior probability of 0.000001. Conclusion Out of 68 published associations of miRNA polymorphisms with cancer, sixteen have shown noteworthiness in our re‐assessing meta‐analysis. Our findings summarize the results of meta‐analyses on the association of cancer with SNPs and underline the importance of interpreting results with caution.

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Section: Resultsmentioning

confidence: 99%

Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta‐analysis

Park

Jeong

Lee

et al. 2020

Eur J Clin Investigation

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“…Wang et al showed increase of the cancer risk in homozygote comparison model due to miR - 196a2 rs11614913 CC genotype as compared to TT genotype [ 19 ]. In a meta-analysis, authors concluded that there was significant linkage between the miR - 196a2 rs11614913 and a reduced risk of cancer, especially a lower risk of gastric cancer and colorectal cancer or for Asian subgroup of population [ 20 ]. Furthermore, in the meta-analysis, Xu et al reported the most probable contribution of the rs11614913 reduces cancer susceptibility, particularly breast cancer in Asia [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

The miRNA 196a2 rs11614913 variant has prognostic impact on Turkish patients with multiple myeloma

et al. 2020

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Objective Multiple myeloma (MM) arises from malignant plasma cells as a single clone in the bone marrow. Accumulating evidences have reported that there is an association between miR-196a2 (rs11614913) variant and various cancers while there were unverified and inconsistent results in MM. The goal of this study is to investigate the impact of the miR-196a2 variant on clinical findings and susceptibility in MM. Two hundred MM patients (156 patients under transplantation of autologous stem cell) and 200 healthy controls included in this study. Results The statistical analysis showed no significant relationship for allele and frequencies of miR-196a2 genotype between patients and controls (p > 0.05). Log-rank test showed that gender has highly significant impact on both OS and PFS (p = 0.027, p = 0.045). In the univariate analysis, TT genotype (p = 0.022), and CT/TT (p = 0.008) had better OS. In the multivariate analysis, CC/CT-TT were associated with positively OS (p = 0.041). Currently, the most valuable prognostic markers in MM that has clinical implication are genetic abnormalities. It can be concluded from the results that miR-1962a variant is effective in prognosis of the MM. It is believed that these findings will help us understand the molecular basis of disease.

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“…MicroRNA-499 rs3746444 has been proved to be signi cantly associated with increased risk of cancer of the respiratory system, digestive system,urinary system and gynecological system [42][43][44][45][46][47][48][49][50][51][52][53].Existing studies have been veri ed that the MiRNA-499(rs3746444 T > C) gene polymorphism can control the expression level of SOX gene. Due to the up-regulation of SOX6 gene, the anti-apoptosis function of MiRNA-499(rs3746444 T > C) can be reversed [54].…”

Section: Discussionmentioning

confidence: 99%

Association of rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E with Prostate Cancer: an updated meta-analysis and systematic review

Liu

Wang

et al. 2020

Preprint

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Background It has been proved that a significant proportion of prostate cancer diagnoses may be associated with a strong hereditary component. Micro-RNAs and Long Non-coding RNAs are a group of a noncoding small molecule, which play critical roles in signalling pathways, metabolism, apoptosis and cancer development. Exercising a meta-analysis to examine the relationship between rs3746444, rs3787016 and prostate cancer (PCa) risk was the main objective of our study. Results 10 case-control studies were included, while 6 on rs3787016 and 4 on rs3746444. On the whole, the genotypes carrying the T allele, in which were verified an increased risk between rs3787016 and PCa risk.( T vs C: odds ratio(OR) = 1.802, 95% CI 1.015–3.198, P value of heterogeneity(PH) = 0.00%; CT vs CC: OR = 1.179,95% CI 1.091–1.275, PH = 0.41; TT vs CC: .OR = 1.418, 95% CI 1.229–1.636, PH= 0.961; TT + CT vs CC: OR = 1.216, 95% CI 1.129–1.310, PH= 0.408; TT vs CT + CC: OR = 1.328, 95%CI 1.159–1.521, PH = 0.987). A vital relevance was performed by this meta-analysis in three models between rs3746444 and PCa risk, in which a tendency of increased PCa risk could be found (C vs T: OR = 1.197, 95% CI 1.035–1.384, PH= 0.837; CC vs TT: OR = 1. 137, 95% CI 0.813–1.590, PH = 0.392; CC + CT vs TT: OR = 1.426, 95% CI 1.166–1.743, PH= 0.406.). Conclusion Our findings proposed that rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E polymorphisms increased the risk of developing PCa. Further functional studies are warranted to reveal the role of the polymorphism in carcinogenesis.

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Association of miR-196a2 rs11614913 and miR-499 rs3746444 polymorphisms with cancer risk: a meta-analysis

Cited by 27 publications

References 84 publications

Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta‐analysis

Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta‐analysis

The miRNA 196a2 rs11614913 variant has prognostic impact on Turkish patients with multiple myeloma

Association of rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E with Prostate Cancer: an updated meta-analysis and systematic review

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