Association of METS-IR index with prevalence of gallbladder stones and the age at the first gallbladder stone surgery in US adults: A cross-sectional study

Abstract

ObjectiveThe purpose of this study was to assess the correlation between the metabolic score for insulin resistance (METS-IR) index and gallbladder stoneprevalence in US adults, as well as the age at first gallbladder stone surgery.MethodsA logistic regression analysis, subgroup analysis, and dose-response curve were computed for participants in the 2017-2018 National Health and Nutrition Examination Survey (NHANES) to assess the relationship between the METS-IR index and gallbladder stone prevalence and age at first surgery for gallbladder stones.ResultsThis study ultimately included 9452 participants aged >20 years, of whom 534 self-reported a history of gallbladder stones, and after adjusting for all confounders, each unit increase in METS-IR index was associated with a 3.3% increase in gallbladder stone prevalence (OR= 1.033, 95% CI: 1.0258, 1.0403) along with an earlier age at first gallbladder stone surgery 0.26 years (β= -0.26, 95% CI: -0.35, -0.17), stratified analysis showed that increased METS-IR index was associated with increased prevalence of gallbladder stones in all subgroups, and the dose-response curve showed a positive linear correlation between METS-IR index and prevalence of gallbladder stones, while a negative linear correlation was observed between increased METS-IR index and age at first gallbladder stone There was a negative linear correlation between age at surgery.ConclusionThe METS-IR index has been positively associated with gallbladder stone prevalence, thereby contributing to age at first surgery for gallbladder stones. However, the causal relationship between the METS-IR and gallbladder stones cannot be concluded.

Higher visceral adiposity index was associated with an elevated prevalence of gallstones and an earlier age at first gallstone surgery in US adults: the results are based on a cross-sectional study

“…The formation of gallstones results from a combination of genetic factors and environmental stimuli. In particular, dietary factors may directly or indirectly lead to the occurrence of gallstones, such as overweight, obesity (26), insulin resistance (13), and metabolic syndrome (27). While VAI is a more specific index than BMI and triglycerides, our results suggest that the female group and white group increased VAI levels in the age group, 60-year-old group, hypertensive/non-hypertensive group, and diabetic/non-diabetic group after adjusting for all confounding factors.…”

“…Women of childbearing age are about twice as likely as men to develop gallstone disease (4). The most important modifiable risk factor for the development of gallstones is metabolic syndrome (13). This includes obesity, dyslipidemia, type 2 diabetes mellitus, insulin resistance, etc.…”

Diabetes Mellitus Mediates the Relationship Between Atherogenic Index of Plasma and Gallstones: A Population-Based Cross-Sectional Study

“…Recently, academics have increasingly ventured into the field of biomarkers associated with gallstones through extensive and comprehensive investigations using the NHANES database. In their study, Wang et al 25 demonstrated a significant association between the metabolic index of insulin resistance score (METS-IR) and the prevalence of gallbladder stones. The results showed a strong and direct correlation, indicating that with every increment in the METS-IR index, there was a proportional rise of 3.3% in the occurrence of gallbladder stones.…”

Elevated visceral adiposity index is associated with increased stroke prevalence and earlier age at first stroke onset: Based on a national cross-sectional study

“…When continuous variables have a large number of missing values, we convert them to categorical variables ( 23 , 24 ), where the missing values form their own group as a dummy variable group.…”