Association of Maternal Prepregnancy Weight and Gestational Weight Gain With Children’s Allergic Diseases

Abstract

Key Points Question Are maternal prepregnancy weight and gestational weight gain associated with childhood allergies? Findings In this cross-sectional study evaluating 8877 children, excessive gestational weight gain was associated with a risk of asthma and/or wheezing, allergic rhinitis, eczema, and food and/or drug allergy, and this risk appeared to be higher when coexisting with maternal prepregnancy overweight or obesity. Low gestational weight gain was associated with a reduced risk of allergies in children of women with low or normal prepregnancy weight, while there was no association in women who were overweight or obese. Meaning The findings of this study suggest that, to meet the challenge of increasing childhood allergies, the management of prepregnancy weight and gestational weight gain must be considered.

Breastfeeding duration modified the effects of neonatal and familial risk factors on childhood asthma and allergy: a population-based study

“…Similar to previous studies [ 2 , 17 , 19 , 27 – 29 ], we found that family history of allergy was strongly associated with increased OR of childhood asthma and allergic diseases. Longer breastfeeding duration could reduce these ORs.…”

“…For instance, the International Study of Asthma and Allergies in Childhood (ISAAC) phase 3 showed a significant increase in the prevalence of childhood asthma and allergic rhinitis (AR) in most of Asia-Pacific region from 2001 to 2010 [1]. With population and economic growth and urbanization, China has been experiencing a rapid increase in the prevalence of childhood asthma and allergic diseases [2][3][4][5]. These changes have brought heavy economic burdens to individuals, families and the society as a whole.…”

Examining the effects of pre-pregnancy weight and gestational weight gain on allergic disease development in offspring: a protocol for a population-based study using health administrative databases in Ontario, Canada

“…5 One 2016 study conducted in Ontario found that 44% of toddlers suffered from food allergies, environmental allergies (wheezing, asthma, eczema or rhinitis), atopy or a combination thereof. 6 Though one cross-sectional and several longitudinal studies have assessed the early-life programming of allergic diseases by maternal weight or GWG, they have been limited by small sample sizes (<1000) 7 8 and self-reported measures of the exposure or outcome, [7][8][9][10][11][12][13][14][15][16][17][18][19] which have reduced their generalisability and validity. Further, most have focused on asthma alone, [7][8][9][10][11][12][13][14] none have examined anaphylaxis and none have calculated risk by the length of follow-up time, opting instead for aggregate rates (loglinear model), 8 13 17 odds (logistic model) 7 9-12 14- 16 18 or prevalence ratios (log-binomial model).…”

“…Further, most have focused on asthma alone, [7][8][9][10][11][12][13][14] none have examined anaphylaxis and none have calculated risk by the length of follow-up time, opting instead for aggregate rates (loglinear model), 8 13 17 odds (logistic model) 7 9-12 14- 16 18 or prevalence ratios (log-binomial model). 19 As well, none of these studies have been undertaken in Canada, which has a unique multicultural population. This proposed research will attempt to address these evidence gaps by carrying out a large population-based study in Canada's most populous province.…”

Breastfeeding duration modified the effects of neonatal and familial risk factors on childhood asthma and allergy: A population-based study

“…For instance, the International Study of Asthma and Allergies in Childhood (ISAAC) phase 3 showed a signi cant increase in the prevalence of childhood asthma and allergic rhinitis (AR) in most of Asia-Paci c region from 2001 to 2010 [1]. With population and economic growth and urbanization, China has been experiencing a rapid increase in the prevalence of childhood asthma and allergic diseases [2][3][4][5]. These changes have brought heavy economic burdens to individuals, families and the society as a whole.…”