1997
DOI: 10.1016/s0925-4439(97)00005-7
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Abstract: Present-day catarrhines (old world monkeys and hominoids) lack Gal alpha1-3 Gal beta1-4 GlcNAc-R structures (alpha-galactosyl epitopes) and produce the corresponding anti-galactosyl antibodies (anti-gal), while platyrrhines (new world monkeys) and non-primate mammals possess alpha-galactosyl epitopes and lack anti-gal. Anti-gal is shown to inhibit Plasmodium falciparum growth in culture in a concentration dependent manner. probably by binding to alpha-galactosyl epitopes on merozoite surface molecules and caus… Show more

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Cited by 27 publications
(24 citation statements)
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“…This epitope is present in most cells of nonprimate mammals and New World monkeys but not in humans, apes, or Old World monkeys. It is also possible that this carbohydrate antigen is present on the surface of the malaria parasite, Plasmodium falciparum (36). Another interesting application of this lectin could be its use in the possible competition with toxin A elaborated by Clostridium difficile, which is responsible for antibiotic-induced diarrhea (37).…”
Section: Figmentioning
confidence: 99%
“…This epitope is present in most cells of nonprimate mammals and New World monkeys but not in humans, apes, or Old World monkeys. It is also possible that this carbohydrate antigen is present on the surface of the malaria parasite, Plasmodium falciparum (36). Another interesting application of this lectin could be its use in the possible competition with toxin A elaborated by Clostridium difficile, which is responsible for antibiotic-induced diarrhea (37).…”
Section: Figmentioning
confidence: 99%
“…By contrast, inhibitory Abs specific for AMA-1, a micronemal protein and constituent of the tight junction, were shown to interfere sterically with the assembly of the protein complex forming the tight junction (28). The modes of action of all invasion inhibitory Abs have not been identified, but suggested mechanisms also include opsonization and destruction of merozoites by phagocytic cells (29,30), complement activation (31), or neutrophil respiratory bursts (32).…”
mentioning
confidence: 99%
“…Loss of a functional GGTA1 gene in catarrhines permitted their expression of anti-Gal antibody (2,17), an effective component of the innate immune system against a variety of ␣Gal-expressing pathogens, via a complement-dependent lysis (6,11,13,15,16,18,(19)(20)(21). As a result, catarrhines may have been indirectly protected from pathogens naturally expressing ␣Gal or from zoonotic transmission of certain viruses acquired from ␣1,3GT-positive species because of the ␣Gal antigens expressed on the pathogen's surface (2,5,6).…”
Section: Discussionmentioning
confidence: 99%
“…The IgG isotype directs cells of the innate immune system, including macrophages, neutrophils, and NK cells, to exert their cytotoxic effects on ␣Gal-expressing tissues, and the IgM isotype induces complement-mediated lysis of ␣Gal-positive cells (6,8). Certain pathogens express ␣Gal on their surfaces; these include bacteria (including those found in primate guts) (4,7,9), protists (10)(11)(12), and viruses derived from hosts that express ␣Gal. Parasite growth is inhibited by antibody-dependent complement-mediated damage (11,13,14).…”
mentioning
confidence: 99%
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