Association of low fetuin-A levels with periodontitis in community-dwelling adults

Abstract

Fetuin-A is a liver-secreted glycoprotein isolated from fetal bovine serum. Recent reports of its several pathological functions suggest an association between fetuin-A and systemic diseases. This study therefore examined the correlation between serum fetuin-A level and periodontal status. Data from 356 middle-aged and elderly adults who underwent health examinations in Goto, Japan, during the period from 2008 through 2010 were analyzed. Systemic and periodontal measurements were recorded, and serum fetuin-A level was determined by using an enzyme-linked immunosorbent assay. Fetuin-A levels for participants with moderate to severe periodontitis were significantly lower than those for participants with no or mild periodontitis. Additionally, fetuin-A level negatively correlated with periodontal clinical attachment loss. Moderate to severe periodontitis was significantly correlated with low serum fetuin-A levels (odds ratio, 1.69; 95% confidence interval, 1.01-2.69) in logistic regression analysis. Low serum fetuin-A level was correlated with worse periodontal status and could thus potentially serve as a marker of periodontitis.

Evaluation of the effect of scaling and root planing on salivary and serum fetuin‐A levels in patients with Stages II and III periodontitis

“…Likewise, a study published by Furugen et al., 18 displayed a significant down regulation of serum fetuin‐A levels with hastened periodontal destruction. Hence, considerable evidence deputes serum fetuin‐A to authentically reflect the extent of periodontal tissue destruction and predict disease progression.…”

“…Upregulated serum fetuin‐A levels after NSPT, as noted in the present study, could help curb systemic calcification that is otherwise known to promote multiple systemic complications. Hence, fetuin‐A could act as a potential conduit, linking a site‐specific inflammatory condition like periodontitis to systemic disorders 18 …”

“…Literature discloses unfeigned data, parading declining levels of fetuin‐A in a site‐specific inflammatory condition, such as periodontitis 16–18 . The present study was conducted based on the hypothesis that fetuin‐A behaves as a negative APP in patients with periodontal disease, and that non‐surgical periodontal therapy (NSPT) enriches their levels.…”

Periodontal İnflamasyon Salya, Serum C-Reaktif Protein ve Fetuin-A Düzeylerini Etkiler mi?

“…Fetuin-A'nın inflamasyon sırasında salgılanan TNF, IL-1, IL-6, interferon gama gibi önemli sitokinler ile negatif korelasyon gösterdiği belirtilmiştir [3]. Fetuin-A'nın anti-inflamatuvar özellikleri göz önüne alındığında periodontal hastalıkla ilişkili olabileceği de düşünülmektedir [12][13][14]. Periodontal hastalıklı bireylerde salya [15], serum [12,14] ve diş eti oluğu sıvısı (DOS) (14) Fetuin-A'nın azaldığı ve periodontal tedavi sonrasında arttığı rapor edilmiştir [13].…”

Two mixed-ligand coordination polymers based on 2,5-thiophenedicarboxylic acid and flexible N-donor ligands: the protective effect on periodontitis via reducing the release of IL-1β and TNF-α

“…Periodontitis is one of the most common oral diseases worldwide. Studies have shown that the invaded pathogens could adhere to the gums and periodontal tissues, multiply, grow, and the metabolic substance produced by the invaded pathogens can activate the immune system, causing edema and bleeding of soft tissue, and formation of periodontal pockets [1,2]. The biggest hidden danger of periodontitis is that periodontitis can induce other systems disease.…”