Association of loneliness with all-cause mortality: A meta-analysis

Rico-Uribe, Laura Alejandra; Caballero, Francisco Félix; Martín‐María, Natalia; Cabello, María; Ayuso-Mateos, José Luís; Miret, Marta

doi:10.1371/journal.pone.0190033

Cited by 401 publications

(325 citation statements)

References 80 publications

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“…There is increasing recognition of the link between loneliness and negative health outcomes. Results from two metaanalyses suggest that loneliness is a predictor of all-cause mortality, with a 22%-26% increased risk of death found in those reporting high levels of loneliness (Holt-Lunstad, Smith, Baker, Harris, & Stephenson, 2015;Rico-Uribe et al, 2018). Loneliness has also been linked with the onset of coronary heart disease (CHD) (Valtorta, Kanaan, Gilbody, Ronzi, & Hanratty, 2016).…”

Section: Introductionmentioning

confidence: 99%

Loneliness and biological responses to acute stress in people with Type 2 diabetes

et al. 2019

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Loneliness is linked with all‐cause mortality and coronary heart disease. Altered neuroendocrine and inflammatory responses to stress constitute potential pathways linking loneliness and ill‐health. Stress responsivity is modified in people with Type 2 diabetes, but it is unclear whether loneliness influences biological stress responses in this population. We assessed interleukin‐6 (IL‐6), interleukin‐1 receptor antagonist (IL‐1RA), monocyte chemoattractant protein‐1 (MCP‐1), and cortisol responses to acute stress in 135 people with Type 2 diabetes. Loneliness was measured used the Revised UCLA Loneliness Scale. Loneliness was inversely associated with cortisol output poststress ( B = −4.429, p = 0.019) independent of age, sex, education, marital status, body mass index, and smoking. Lonelier individuals had raised MCP‐1 concentrations 75 min poststress independent of covariates ( B = 0.713, p = 0.022). No associations between loneliness and IL‐6 or IL‐1RA concentrations were detected. These results suggest that loneliness is associated with disturbances in stress responsivity in people with diabetes, and the impact of loneliness on health in people with diabetes may be mediated in part through dysregulation of inflammatory and neuroendocrine systems. Future research is required to understand if such changes increase the risk of poorer outcomes in this population.

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Section: Introductionmentioning

confidence: 99%

Loneliness and biological responses to acute stress in people with Type 2 diabetes

et al. 2019

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“…9 One of the measures of the perceived quality of social relationships is loneliness, 2 the sense of distress derived from perceived deficiencies in the social relationships one desires to have. 11 One's living arrangement, consisting primarily of social relationships of family members who share a set of cultural norms and values, represents a pivotal household context that promotes and/or restricts relationships, including their quantity and function. 11 One's living arrangement, consisting primarily of social relationships of family members who share a set of cultural norms and values, represents a pivotal household context that promotes and/or restricts relationships, including their quantity and function.…”

Section: Introductionmentioning

confidence: 99%

“…10 Loneliness has been reported by a number of studies as a significant risk factor for mortality. 11 One's living arrangement, consisting primarily of social relationships of family members who share a set of cultural norms and values, represents a pivotal household context that promotes and/or restricts relationships, including their quantity and function. 12 Although some research findings show that older adults' living alone is associated with a higher mortality rate, 13 some report otherwise.…”

Section: Introductionmentioning

confidence: 99%

Japanese older adults’ loneliness, family relationships and mortality: Does one's living arrangement make a difference?

Takagi

Saito

2019

Geriatrics Gerontology Int

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Aim: This study examines how the association between older adults' family relationships and all-cause mortality differs among different household contexts: living alone, living with only a spouse and living with adult children.Methods: We carried out a discrete-time event history analysis on all-cause mortality with measures of family relationships for each group of older adults. The study analyzed personwave data from the Nihon University Japanese Longitudinal Study of Aging, including 11 225 longitudinal episodes between consecutive waves and 555 deaths reported in total.Results: The family relationship measures were significantly associated with mortality only for older adults who resided with children. While providing support to children was negatively related to mortality, receiving support from children was positively associated with mortality. Feelings of loneliness were associated with higher mortality for older adults in intergenerational coresidence arrangements, but not for those in other living arrangements. Conclusion:The extent of support exchange between older adults and adult children tends to be associated with older adults' mortality only within the household context where parents and children live together. In other types of living arrangements (i.e. living alone and living with only a spouse), the association between family relationship measures and mortality is limited. Geriatr Gerontol Int 2020; 20: 156-160.

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“…Social contact has been connected to the release of oxytocin (Holt-Lunstad et al 2008). Loneliness has been associated with all-cause mortality in a previous meta-analysis study (Rico-Uribe et al, 2018). Specifically, it was found that individuals who have an anxious attachment style have an increased neurological sensitivity to social distress.…”

Section: Discussionmentioning

confidence: 98%

Social Isolation as a predictor for mortality: Implications for COVID-19 prognosis

Banerjee

Burkholder

Sana³

et al. 2020

Preprint

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The health benefits of social support have been widely documented. However, the social distancing practices from the COVID-19 pandemic is causing social disruption on a grand scale, potentially causing poor health outcomes. Through Google Trends analysis, we found a COVID-19-related surge in interest surrounding "loneliness." We assessed if social isolation and loneliness increase the risk for all-cause and cardiovascular disease (CVD) mortality (ICD-10: I00-I99) and used the data to create a conceptual framework. Using the 10-year overall and cardiovascular mortality follow-up data (n = 12,019) from the National Health and Nutrition Examination Survey (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008), we conducted survival analyses and found that individuals who experience social isolation or loneliness have a significantly higher likelihood of overall and CVD mortality than those without support. These effects generally remained strong with further adjustment for NHANES-detected health and demographic differences showing the need to address COVID-19 related loneliness through increasing social nearing.

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Association of loneliness with all-cause mortality: A meta-analysis

Cited by 401 publications

References 80 publications

Loneliness and biological responses to acute stress in people with Type 2 diabetes

Loneliness and biological responses to acute stress in people with Type 2 diabetes

Japanese older adults’ loneliness, family relationships and mortality: Does one's living arrangement make a difference?

Social Isolation as a predictor for mortality: Implications for COVID-19 prognosis

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