Association of level of physical activity with outcomes of acute coronary syndrome

Abstract

Funding Acknowledgements Type of funding sources: Other. Main funding source(s): Primary Investigator funded Department of Internal Medicine Funded Background Acute coronary syndrome or "Heart Attack" is a medical emergency that takes the world by storm. Closely linked to this is a sedentary lifestyle that ls known by most to increase its likelihood. Unfamiliar to the majority is a tool called "International Physical Activity Questionnaire (IPAQ)" that can measure the level of activity to low, moderate and high intensity. Purpose In this study, the IPAQ will be utilized to determine the association of level of physical activity with outcomes of acute coronary syndrome through 30 days major adverse cardiovascular events (MACE). This can contribute to the knowledge of predicting likelihood of MACE after coronary syndromes and help discern aggressiveness of treatment. Methods This is a single - center prospective cohort study that was performed in a tertiary hospital. The participants included patients with ages 30 to 69 admitted with a diagnosis of acute coronary syndrome from September 2020 to November 2020. T - Test and Odds Ratio were employed to compute for likelihood of MACE 30 days after acute coronary syndrome. Results A total of 33 participants were included with mean age of 61 years. Fifty five percent were female. Majority of the patients were overweight with hypertension as the most common co morbidity. Among the participants, 36% (12) have low physical activity and 64% (21) have moderate to high physical activity. Upon follow up of participants, low physical activity showed significantly higher incidence of MACE (58%) versus moderate-high level of physical activity (24%). The odds ratio for low level of physical activity is 4.5 with 95% confidence interval (0.975 - 20.806) and 0.25 for moderate to high physical activity. Conclusion Analysis of the results revealed that low level of physical activity resulted with twice the proportion of 30- day MACE as compared to moderate-high activity. Association of level of physical activity with outcomes of ACS showed a 4.5 times more likelihood of developing MACE after 30 days for low level of physical activity. Association of Activity to Risk of MACE Odds 95% CI P-value Level of physical Acitivty Lower Limit Upper Limit Low 4.504 0.975 20.806 0.054 Moderate to High 0.251 0.056 1.134 0.072