Association of language dysfunction and age of onset of benign epilepsy with centrotemporal spikes in children

Jurkevičienė, Giedrė; Endzinienė, Milda; Laukienė, Ilona; Šaferis, Viktoras; Rastenytė, Daiva; Plioplys, Sigita; Vaičienė-Magistris, Nerija

doi:10.1016/j.ejpn.2012.03.011

Cited by 44 publications

(36 citation statements)

References 61 publications

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“…Furthermore, the current study demonstrates the relevance of the effect of age in RE and proposes to adopt the view that RE represents a deviation from the normal developmental trajectory of the brain in a critical period of brain maturation. The earlier this deviation occurs, the more severe the consequences, with children of age at seizure onset below 6 years being having the lowest language performance (Jurkeviciene et al, 2012). This warrants further research into whether it is possibly to exploit the increased brain plasticity in this critical period as a window of opportunity to redirect aberrant development onto a normal trajectory (Andersen, 2003).…”

Section: Discussionmentioning

confidence: 99%

Early onset of cortical thinning in children with rolandic epilepsy

Overvliet

Besseling

Jansen

et al. 2013

NeuroImage: Clinical

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IntroductionRolandic epilepsy, a childhood epilepsy associated with language impairments, was investigated for language-related cortical abnormalities.MethodsTwenty-four children with rolandic epilepsy and 24 controls (age 8–14 years) were recruited and underwent the Clinical Evaluation of Language Fundamentals test. Structural MRI was performed at 3 T (voxel size 1 × 1 × 1 mm3) for fully automated quantitative assessment of cortical thickness. Regression analysis was used to test for differences between patients and controls and to assess the effect of age and language indices on cortical thickness.ResultsFor patients the core language score (mean ± SD: 92 ± 18) was lower than for controls (106 ± 11, p = 0.0026) and below the norm of 100 ± 15 (p = 0.047). Patients showed specific impairments in receptive language index (87 ± 19, p = 0.002) and language content index (87 ± 18, p = 0.0016). Cortical thickness was reduced in patients (p < 0.05, multiple-comparisons corrected) in left perisylvian regions. Furthermore, extensive cortical thinning with age was found in predominantly left-lateralized frontal, centro-parietal and temporal regions. No associations were found between cortical thickness and language indices in the regions of aberrant cortex.ConclusionThe cortical abnormalities described represent subtle but significant pathomorphology in this critical phase of brain development (8–14 years) and suggest that rolandic epilepsy should not be considered merely a benign condition. Future studies employing longitudinal designs are prompted for further investigations into cerebral abnormalities in RE and associations with cognitive impairment and development.

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Section: Discussionmentioning

confidence: 99%

Early onset of cortical thinning in children with rolandic epilepsy

Overvliet

Besseling

Jansen

et al. 2013

NeuroImage: Clinical

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“…The prognosis for seizure outcome in BECTS is excellent; most patients have less than 10 seizures, and seizure activity is expected to cease by adulthood (Blom & Heijbel, 1982; Camfield & Camfield, 2002; Dalla Bernardina, Sgro, & Fejerman, 1995; Loiseau, Duche, Cordova, Dartigues, & Cohadon, 1988; Panayiotopoulos, 1999). However, a growing body of literature has documented subtle cognitive and/or behavioral problems in children with BECTS, particularly affecting language function (Baglietto et al, 2001; Danielsson & Petermann, 2009; Ebus, Overvliet, Arends, & Aldenkamp, 2011; Goldberg-Stern et al, 2010; Jurkeviciene et al, 2012; Northcott et al, 2005; Overvliet, Aldenkamp, Klinkenberg, Nicolai, et al, 2011; Overvliet, Besseling, van der Kruijs, et al, 2013; Overvliet, Besseling, et al, 2011; Samaitiene, Norkuniene, Jurkeviciene, & Grikiniene, 2012; Samaitiene, Norkuniene, Tumiene, & Grikiniene, 2013; Verrotti, Filippini, Matricardi, Agostinelli, & Gobbi, 2014; Volkl-Kernstock, Bauch-Prater, Ponocny-Seliger, & Feucht, 2009). …”

Section: Introductionmentioning

confidence: 99%

“…However, children with BECTS perform poorly when compared to controls on tests of expressive language (including naming and verbal fluency), receptive language, and verbal memory skills (Danielsson & Petermann, 2009; Garcia-Ramos et al, 2015; Goldberg-Stern et al, 2010; Overvliet, Besseling, van der Kruijs, et al, 2013; Piccinelli et al, 2008; Volkl-Kernstock et al, 2009). Earlier age of onset has been suggested to be associated with lower language scores (Jurkeviciene et al, 2012; Ma, Chen, Wang, & Xu, 2015) and, in fact, delayed language skills may appear as a precursor to the diagnosis of BECTS (Overvliet, Aldenkamp, Klinkenberg, Vles, & Hendriksen, 2011). These authors noted that 23% of 48 children with BECTS had a history of speech therapy and 35% repeated a year in primary school, both higher than the general population.…”

Section: Introductionmentioning

confidence: 99%

Changes in functional organization and functional connectivity during story listening in children with benign childhood epilepsy with centro-temporal spikes

et al. 2019

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Children with Benign Epilepsy with Centrotemporal Spikes (BECTS), despite high likelihood for seizure remission, are reported to have subtle difficulties in language and other cognitive skills. We used functional MRI and a story listening task to examine the effect of BECTS on patterns of activation and connectivity. Language and cognitive skills were assessed using standardized measures. Twenty-four children with recently diagnosed BECTS and 40 typically-developing children participated. In a functionally-defined region of interest in right inferior frontal gyrus, BECTS patients showed a lower level of activation. Across both groups combined, increased activation in superior/middle temporal regions of interest was associated with better language scores. Connectivity in the story processing network was similar between groups, but connectivity within left inferior frontal gyrus was decreased in children with BECTS. These results suggest that language networks are largely maintained in new-onset BECTS, but some subtle changes in activation and connectivity can be observed.

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“…Specifically, general intellectual function (Full Scale IQ) is in the average range in most studies of BECTS patients, as is true for the larger population of individuals with epilepsy, but specific cognitive domains may be more affected. Most consistently reported is poorer performance on tests of language and verbal memory compared to healthy controls, as well as attention and processing speed . These problems may underlie difficulties in academic achievement .…”

mentioning

confidence: 99%

Impact of frequency and lateralization of interictal discharges on neuropsychological and fine motor status in children with benign epilepsy with centrotemporal spikes

et al. 2016

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SUMMARY Despite a positive prognosis for seizure remission, children with Benign Epilepsy with Centrotemporal Spikes (BECTS) have been reported to exhibit subtle neuropsychological difficulties. We examined the relationship between patterns of centrotemporal spikes (typical EEG finding in BECTS) and neuropsychological and motor outcomes in children with new-onset BECTS. Thirty-four patients with new-onset BECTS (not taking antiepileptic medication) and 48 typically-developing children participated in the study. In BECTS patients, centrotemporal spikes (CTS) were evaluated in the first hour awake and first two hours of sleep in a 24-hour EEG recording and left or right-sided origin was noted. General intellectual function, language, visuospatial skill, processing speed and fine motor skill were assessed in all participants. We found no significant difference between BECTS patients and controls on measures of general intellectual function, visuospatial or language testing. There were significant differences in Processing Speed Index and non-dominant hand fine motor scores between groups. Significant negative relationships were observed between rates of left-sided CTS and right hand fine motor scores. This suggests that psychomotor and fine motor speed are affected in BECTS, but the extent of affected domains may be more limited than previously suggested, especially in untreated patients early in the course of their epilepsy.

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Association of language dysfunction and age of onset of benign epilepsy with centrotemporal spikes in children

Cited by 44 publications

References 61 publications

Early onset of cortical thinning in children with rolandic epilepsy

Early onset of cortical thinning in children with rolandic epilepsy

Changes in functional organization and functional connectivity during story listening in children with benign childhood epilepsy with centro-temporal spikes

Impact of frequency and lateralization of interictal discharges on neuropsychological and fine motor status in children with benign epilepsy with centrotemporal spikes

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