Association of interleukin-10 (A1082G) gene polymorphism with oral squamous cell carcinoma in north Indian population

Abstract

The functional polymorphism A1082G in the gene (IL10) for interleukin-10 associated with risk of oral squamous cell carcinoma (OSCC). The present case-control study was to evaluate the possible association between IL10 A1082G gene and OSCC in north Indian population. Analysis of IL10 A1082G genotype in 232 OSCC cases and 221 healthy controls of comparable age, gender, smokers, tobacco chewing and alcohol consumption. IL10 A1082G status in cases and controls were evaluated by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The frequencies of IL10 A1082G polymorphism AA, AG, GG genotypes were 29.74, 68.10 and 2.15% in OSCC cases and 57.46, 42.08 and 0.45% in healthy controls. The average frequency of G mutant allele was 36.20% in OSCC cases compared with 21.50% among the controls and this allele was associated with increased risk for OSCC cases. Heterozygous AG genotype was found statistically significant in OSCC cases than in controls (OR = 1.6, 95% CI = 1.1-2.2, P = 0.003), whereas homozygous mutant GG genotype was not found significant (OR = 4.7, 95% CI = 0.55-41.1, P = 0.2). Moreover, we found that G allele was significant in OSCC cases of tobacco chewing. The frequency of IL10 A1082G polymorphism G allele and AG genotype is associated with OSCC cases as compared with controls; this may be due to smoking and tobacco chewing. Our findings showed that in IL10 A1082G gene polymorphism AG genotype and G allele may participate in the progression of OSCC.

Association of Interleukin-10 Genotypes and Oral Cancer Susceptibility in Selected Malaysian Population: A Case- Control Study

“…At the same time, no obvious association between IL10 A1082G genotype and alcohol drinking was found (Tsai et al, 2014). Another case control study in India Hussain et al, (2016) revealed that among AA, AG, GG genotypes, an increase AG genotype cases as compared to control was found to be statistically significant. Thus the G allele of IL10 may be involved in the progression of OSCC.…”

“…The etiology of a specific cancer might be associated with genetic variants. IL10 polymorphisms like A1082G/AA/AG/GG genotypes may not only contribute to differential expression levels of IL10 among individuals but may also lead the risk oral cancer susceptibility (Hussain et al, 2016).…”

Chemoprotective effect of nanocurcumin on 5-fluorouracil-induced-toxicity toward oral cancer treatment

“…[ 1 ] Oral cancer has reported high prevalence rate globally, approximately 4 lakh new cases have reported annually with 39% death rate. [ 2 ] The survival rate is about 5 years for oral cancer patients. [ 3 ] The South Asian country, specifically Indian subcontinent, has a reported very high rate of oral cancer patients due to poor prognosis and delay in treatment.…”

Signature of genetic associations in oral cancer

“…These cytokines, studied at both mutation and expression level, may serve as biomarkers of prognostic value. [90][91][92][93] The heterogeneity in cancer cells between and/or within patients makes it a complex disease to cure. 94 Identifying germ line mutations which may serve as biomarkers for predicting OC-susceptible individuals and/or who may respond differently to a particular cancer therapy is very important.…”