Association of increased oncostatin M with adverse left ventricular remodeling in patients with myocardial infarction

Abstract

Background: The study of laboratory biomarkers that reflect the development of adverse cardiovascular events in the postinfarction period is of current relevance. The aim of the present study was evaluation of oncostatin M (OSM) concentration changes in the early and late stages of myocardial infarction and evaluation of the possibility of its use in prediction of adverse left ventricular remodeling in patients with myocardial infarction with ST-elevated segment (STEMI).
 Methods: The study involved 31 patients with STEMI admitted in the first 24 hours after the onset of MI and 30 patients with chronic coronary artery disease as a control group. Echocardiographic study was performed on day 3 and in 6 months after STEMI. The serum levels of biomarkers were evaluated on the day of hospital admission and 6 months after MI using multiplex immunoassay.
 Results: OSM level increased during the first 24 h after the onset of the disease, with the following decrease in 6 months. OSM concentration at admission had correlated with echocardiography parameters and Nt-porBNP, troponin I, CK-MB levels. Our study has demonstrated association of the increased levels of OSM at the early stages of STEMI with development of the adverse LV remodeling in 6 months after the event.
 Conclusion: Elevation of OSM levels in the first 24 h after STEMI is associated with the development of the adverse LV remodeling in the long-term post-infarction period.

Spexin level in acute myocardial infarction in the emergency department

“…One of the most common reasons for admitting patients to the emergency department is chest pain [1] . Approximately 10–20% of patients admitted with chest pain are diagnosed with acute coronary syndrome (ACS) [2] , while more than half have non-cardiac causes [1] [3] . Because of the significant risk of mortality and morbidity in ACS patients, early detection and prompt initiation of treatment are critical, but it is essential to rule out causes of chest pain that do not require immediate medical attention [4] .…”

Association of Increased Oncostatin M with Adverse Left Ventricular Remodeling in Patients with Myocardial Infarction

“…Myocardial infarction is the leading cause of death worldwide. Patients suffering from myocardial infarction with a ST-elevated segment termed as STEMI experience high risk of death and these patients report recurrent attacks even more as compared to other MI patients 1 . STEMI ultimately leads to heart failure and death.…”

Em Busca do Marcador Perfeito

“…It should clarify several aspects of antagonistic effects of protection or worsening of coronary disease, as described in the literature. 8,9 Personalized medicine is a concept that all physicians should strive to offer their patients, keeping in mind that these are individuals with unique needs and disease patterns. Technology brings us new tools to personalize care, and its perspective on cardiovascular care is endless.…”

“… 7 Entretanto, mais pesquisas são necessárias para compreender plenamente seu papel na DAC e como podem ser utilizados na prática clínica, devendo esclarecer diversos aspectos dos efeitos antagônicos de proteção ou agravamento da doença coronariana, conforme descrito na literatura. 8 , 9 …”

“…It should clarify several aspects of antagonistic effects of protection or worsening of coronary disease, as described in the literature. 8 , 9 …”