Association of IL18 genetic polymorphisms with increased risk of Biliary atresia susceptibility in Southern Chinese children

Liang, Jianhua; Wang, Zhe; Zhao, Jianhao; Liang, Qifeng; Liu, Tao; Xia, Huimin; Zhang, Yan; Zhang, Ruizhong

doi:10.1016/j.gene.2018.07.071

Cited by 9 publications

(7 citation statements)

References 17 publications

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“…It is a fairly safe bet that there will be an increasingly important and significant proportion from Asia . From a standing start in the early 2000s, much of the current BA research already originates from Chinese institutions . Perhaps, surprisingly given the relatively huge numbers of infants being treated by centers in Beijing and Shanghai , the accent has been on basic science and laboratory‐based studies.…”

Section: Discussionmentioning

confidence: 99%

Biliary atresia: a scientometric analysis of the global research architecture and scientific developments

Friedmacher

Ford

Davenport

2019

J Hepato Biliary Pancreat

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Biliary atresia (BA) is a rare cholangiopathy of largely unknown etiology and unpredictable outcome. There has been an increasing number of BA-related publications, which may challenge researchers to determine their actual scientific value. This study aimed to evaluate the global research activity and developments relating to BA using a combination of scientometric methodologies and visualization tools. A comprehensive search strategy for the Web of Science TM database was designed to obtain bibliographic data on scientific BA publications for the timespan 1900-2018. Research output of countries, institutions, individual authors and collaborative networks was analyzed. Semi-qualitative research measures including citation rate and h-index were assessed. Choropleth mapping and network diagrams were used to visualize results. In total, 4,459 publications on BA were identified (88.5% in English), originating from 63 countries. The largest number was published by the USA (n = 991; 22.2%), Japan (n = 667; 15.0%) and the UK (n = 294; 6.6%). The USA combined the highest number of cooperation articles (n = 140). The most productive collaborative network was established between the USA and Canada (n = 17). Scientific papers from the UK received the highest average citation rate (16.7), whereas the USA had the highest country-specific h-index (59). Eighty-eight (2.0%) items were published under the auspices of multicenter consortiums and registries. The most productive institutions and authors were based in the USA, the UK, Japan, France, Canada and Taiwan. BArelated research has constantly been progressing, becoming more multidisciplinary but with main research endeavors concentrated in a few high-income countries. Studies into pathogenesis of BA remain uncommon, but are sorely needed to foster true scientific progress with this rare disease. Hence, international collaborative and translational research should be strengthened to allow further evolution in this field.

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Section: Discussionmentioning

confidence: 99%

Biliary atresia: a scientometric analysis of the global research architecture and scientific developments

Friedmacher

Ford

Davenport

2019

J Hepato Biliary Pancreat

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“…58 Especially in ethnicities with apparently higher susceptibility for BA, like New Zealand Maori and Southern Chinese, genetic footprints were researched and have shown associated genetic polymorphisms. [59][60][61] Tian et al recently presented another important step to an in vitro human BA model, based on disease-specific induced pluripotent stem cells (iPSCs) and showing that BA-specific iPSCs result in defective biliary differentiation. 62 In the future, this result could potentially help to recapitulate key disease features from a patient's iPSCs.…”

Section: Discussionmentioning

confidence: 99%

Translational Research in Biliary Atresia: News from Mice and Men

Madadi-Sanjani

Petersen

2019

Eur J Pediatr Surg

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Biliary atresia (BA) is a fibro-obliterative cholangiopathy of unknown etiology. While Kasai portoenterostomy achieves temporary biliary drainage in some cases, BA remains the most common indication for liver transplantation during childhood. During the last few decades, observations on BA, like cholestatic diseases in animals and the introduction of different animal models for BA, have not achieved the anticipated results, and we are still not able to translate the basic research to the patient's bedside. This article presents a review of the literature on available BA animal models and gives a glimpse of future developments.

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“…Susceptible genes are selected according to the following criteria: (1) SNPs are significantly correlated with BA cohort; (2) It is verified by multiple cohorts or animal disease models; (3) its biological function is closely related to the four aspects described in our review. Some genes, such as IL18, CD14, NOTCH2 and so on, are only reported by one cohort are not in text but in Table 1 (34)(35)(36)(37)40). Genes that may be susceptible genes but have not yet been found BA are selected according to the following criteria: (1) Abnormal expression in BA specimens; (2) Demonstrated by animal disease models; (3) Their biological function is closely related to the four aspects described in our review.…”

Section: Genetic Factors In Bamentioning

confidence: 99%

Genetic Factors and Their Role in the Pathogenesis of Biliary Atresia

Sun²

2022

Front. Pediatr.

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Biliary Atresia, a common basis for neonatal cholestasis and primary indication for Liver Transplantation, accounts for 60% of pediatric Liver Transplantations. While the pathogenesis of Biliary Atresia remains obscure, abnormalities within bile ducts and the liver, inflammation, fibrosis and cilia defects are thought to comprise the pathological basis for this condition. The findings of genetic variants in Biliary Atresia, such as Copy Number Variations and Single Nucleotide Polymorphism, are considered as essential factors in the development of this condition. In this review, we summarize and analyze these Biliary Atresia variants from a perspective of their pathological characteristics. In conclusion, such analyses may offer novel insights into the pathogenesis of Biliary Atresia and provide a foundation for future studies directed toward a better understanding and treatment of Biliary Atresia.

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Association of IL18 genetic polymorphisms with increased risk of Biliary atresia susceptibility in Southern Chinese children

Cited by 9 publications

References 17 publications

Biliary atresia: a scientometric analysis of the global research architecture and scientific developments

Biliary atresia: a scientometric analysis of the global research architecture and scientific developments

Translational Research in Biliary Atresia: News from Mice and Men

Genetic Factors and Their Role in the Pathogenesis of Biliary Atresia

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