Association of IGF 1 gene polymorphisms with some morphometric traits of Nigerian indigenous sheep breeds

Raji, A. O.; Mohammed, Ali Ibrahim; Igwebuike, J. U.; Alphonsus, C.

doi:10.4314/njb.v34i1.13

Cited by 3 publications

(2 citation statements)

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“…Gholibeikifard et al (2013) discovered no relationship between exon 3 IGF-1 polymorphism and birth, weaning, six-month, nine-month, and once-a-year weights for the Baluchi sheep. Similarly, Raji et al (2018) stated that the polymorphisms IGF-1 gene did not significantly affect the height at withers of Makui sheep in Iran as well as the morphometric traits in Uda sheep. The three authors, however, observed genotypes AA, AB, and BB did not differ, but BB had higher body length measurements significantly (p<0.05) compared to AA and AB girth, height at withers, and body weight.…”

Section: Relationship Of Genotype With Body Sizementioning

confidence: 99%

Polymorphisms of Palu Sheep IGF-1 Gene and Their Relationship with Skeletal Growth

Malewa

Awaluddin

2022

Trop. Anim. Sci. J.

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This study aims to examine the polymorphisms of the IGF-1 gene associated with body weight and size. A total of 60 sheep from different farm locations in Palu City (Villages of Taipa, Poboya, Kawatuna, and Petobo), Central Sulawesi, Indonesia, were used. The variables observed were adult body weight and measurements, such as shoulder height, body length, humerus length, radiusulna length, metacarpus length, hip height, femur length, tibial length, and metatarsus length as phenotypic characteristics. IGF-1 gene polymorphisms were analyzed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) with Bsp143|| as a restriction enzyme. These gene polymorphisms were calculated using the allele and genotype frequency approach, as well as the Polymorphic Informative Content (PIC). Genotype associations with body weight and bone size were analyzed using the General Linear Model analysis method. The PCR-RFLP analysis results showed the presence of polymorphisms with the frequency and genotypes of GG (21.7%), GC (68.3%), and CC (10%). Furthermore, the frequencies of G (55.8%) and C (44.2%) genes with a 49.32% polymorphism rate (PIC) were not in the Hardy-Weinberg equilibrium (p<0.05).In conclusion, the IGF-1 gene polymorphism was detected in Palu sheep with an insignificant effect on body weight and bone size.

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Section: Relationship Of Genotype With Body Sizementioning

confidence: 99%

Polymorphisms of Palu Sheep IGF-1 Gene and Their Relationship with Skeletal Growth

Malewa

Awaluddin

2022

Trop. Anim. Sci. J.

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“…v.78, n.3, e20190216, 2021 2016). Furthermore, association between a PCR-RFLP in the regulatory region of IGF1 with BL, TW, and body weight in Balami sheep, and WH in Yankasa sheep were also reported (Raji et al, 2017). A PCR-SSCP in exon-1 was associated with ADG and BL in Makui sheep (Hajihosseinlo et al, 2013), and ADG in both Baluchi (Tahmoorespur et al, 2009) and Makooei (Negahdary et al, 2013) sheep breeds.…”

Section: Variants Associated With Body Traitsmentioning

confidence: 93%

Variants in GH, IGF1, and LEP genes associated with body traits in Santa Inês sheep

Machado

Meira

Jucá

et al. 2021

Sci. agric. (Piracicaba, Braz.)

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Correlation analysis between polymorphism of leptin and IGFI genes and body measurements in Barki and Farafra sheep

Darwish,

Abdelhafez,

Abdel-Hamid

et al. 2023

Beni-Suef Univ J Basic Appl Sci

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Background Growth performance, which can be evaluated using various body measurements, is crucial for providing red meat for human consumption. This study aims to improve the growth performance of sheep by identifying the different genotypes of leptin and IGFI genes associated with higher body measurements. Methods In this study, we collected blood samples from Barki (n = 30) and Farafra (n = 30) sheep, and measured their body height, width, length, and weight, and tail width and length to assess their growth performance. We used single strand conformation polymorphism polymerase chain reaction (SSCP-PCR) and sequencing analysis to identify single nucleotide polymorphisms (SNPs) and different genotypes of the leptin and insulin-like growth factor receptor (IGFI) genes associated with sheep body measurements. Results The leptin gene (209 bp) and IGFR gene (345 bp) were found to have three (TT, TG, and GG) and (TT, TC, and CC) genotypes, respectively, by SSCP-PCR. Sequence analysis revealed a SNP in the leptin gene (200G > T) with two alleles (G allele: OR058867 and T allele: OR058868). This SNP resulted in the substitution of the amino acid valine with leucine, which increased the width, length, and weight of the body and tail width in the heterozygous form (TG). The IGFI gene had three SNPs: 305 G > T in TT genotype (OR260670), 184C > T, 265T > C, and 305G > T in TC genotype (OR260669), and 265T > C in CC genotype (OR260671). The TC genotype of the IGFR gene was correlated with higher values of body measurements. Barki sheep were found to have the highest values for body weight, width, length, and tail width compared to Farafra sheep. Conclusion We recommend the use of entire Barki sheep in inbreeding programs to improve growth performance in Egyptian sheep.

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Association of IGF 1 gene polymorphisms with some morphometric traits of Nigerian indigenous sheep breeds

Cited by 3 publications

References 0 publications

Polymorphisms of Palu Sheep IGF-1 Gene and Their Relationship with Skeletal Growth

Polymorphisms of Palu Sheep IGF-1 Gene and Their Relationship with Skeletal Growth

Variants in GH, IGF1, and LEP genes associated with body traits in Santa Inês sheep

Correlation analysis between polymorphism of leptin and IGFI genes and body measurements in Barki and Farafra sheep

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