Association of<i>MYO9B</i>gene polymorphisms with inflammatory bowel disease in Chinese Han population

Hu, Jing; Qiao, Mu; Huang, Jian; Hu, Naizhong; Liu, Xiao-Chang; Xu, Jianming

doi:10.3748/wjg.v20.i23.7466

Cited by 4 publications

(12 citation statements)

References 36 publications

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“…Five SNPs within MY09B gene were investigated, including rs1545620, rs962917, rs1457092, rs2305764 and rs2305767. Genotype distributions of the controls about rs1545620 in one study [ 17 ] did not conform to HWE [ 17 ] ( P = 0.002). The NOS scores of all included studies ranged from 5 to 7 stars, which suggested they were studies of high methodological quality.…”

Section: Resultsmentioning

confidence: 99%

“…The NOS scores of all included studies ranged from 5 to 7 stars, which suggested they were studies of high methodological quality. Six papers were carried out in Caucasian populations [ 14 - 16 , 18 , 20 , 21 ], and two in Asian populations [ 17 , 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…We did not find rs1545620 was related with UC or CD risk in Caucasian or Asian populations. By exclusion of one Chinese study that did not conform to HWE [ 17 ], the pooled estimates of the remaining studies also showed that rs1545620 polymorphism might decrease the risk of IBD (CC vs . AA+AC: OR, 0.53; 95% CI, 0.41-0.69, P < 0.001) (Table 3 ), suggesting that the results of this SNP was stable.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies [ 16 , 17 , 21 ] with 2,993 cases and 2,005 controls investigated rs962917 polymorphism. As shown in Table 4 , rs962917 polymorphism was associated with an increased risk of IBD.…”

Section: Resultsmentioning

confidence: 99%

“…To date, several studies have assessed associations between MYO9B gene polymorphisms and IBD susceptibility; however, they reported conflicting results. Several studies [ 14 , 17 , 19 , 21 ] did not find MYO9B to be a candidate gene for IBD, while other studies [ 15 , 16 , 18 , 20 ] suggested this gene was significantly associated with IBD, CD or UC risk. However, these studies had inadequate statistical power and involved relatively small samples.…”

Section: Discussionmentioning

confidence: 99%

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MYO9B gene polymorphisms are associated with the risk of inflammatory bowel diseases

Wang

Yao

et al. 2016

Oncotarget

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Myosin IXB (MYO9B) gene polymorphisms have been extensively investigated in terms of their associations with inflammatory bowel disease (IBD), with contradictory results. The aim of this meta-analysis was to evaluate associations between MY09B gene polymorphisms and the risk of IBD, Crohn's disease (CD) and ulcerative colitis (UC). Eligible studies from PubMed, Embase, and CNKI databases were identified. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Ten studies published in eight papers reporting 8,975 cases and 9,482 controls were included in this meta-analysis. Five MY09B gene polymorphisms were evaluated: rs1545620, rs962917, rs1457092, rs2305764, and rs2305767. Our data suggested that the rs1545620 polymorphism was associated with a decreased risk of IBD. A similar result was found for rs2305767 and UC. The rs962917 single nucleotide polymorphism (SNP) increased the risk of IBD, CD and UC. Moreover, rs1457092 increased the risk of IBD and UC. Rs2305764 was also associated with an increased risk of IBD. Furthermore, stratification analyses indicated that rs1545620 decreased the risk of IBD, while rs962917 increased the risk of IBD, CD and UC in Caucasian populations. To sum up, our data indicate that these five SNPs in MY09B are significantly associated with the risk of IBD.

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Section: Resultsmentioning

confidence: 99%