Association of <i>Helicobacter pylori</i> Infection With Psoriasis and Lichen Planus: Prevalence and Effect of Eradication Therapy

Daudén, Esteban; Vázquez-Carrasco, Maria-Angeles; Peñas, Pablo F.; Pajares, J. M.; García‐Diez, Amaro

doi:10.1001/archderm.136.10.1275

Cited by 21 publications

(21 citation statements)

References 4 publications

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“…These differences could result from the fact that the wound surface of aphthous ulcers, histopathologically a breach of the epithelial barrier due to a possible immune reaction against the oral mucosa, 47 presents a different environment for bacterial adhesion than the clinically intact epithelium in asymptomatic OLP lesions. H. pylori also was identified in aphthous stomatitis 48 . H. pylori was rarely detected in the oral cavity by culture technique, but it was frequently detected by nested PCR, especially among periodontitis patients who had the bacterium in their gastrointestinal tract 49 .…”

Section: Discussionmentioning

confidence: 99%

Microbiological Findings in Subjects With Asymptomatic Oral Lichen Planus: A Cross‐Sectional Comparative Study

Bornstein

Hakimi

Persson

2008

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Microbiological Findings in Subjects With Asymptomatic Oral Lichen Planus: A Cross‐Sectional Comparative Study

Bornstein

Hakimi

Persson

2008

Journal of Periodontology

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“…To this end, several studies have investigated a possible link between H. pylori and psoriasis [67][68][69][70][71][72][73][74] .…”

Section: Psoriasismentioning

confidence: 99%

Helicobacter pyloriand autoimmune disease: Cause or bystander

Smyk¹,

Κουτσουμπασ²,

Mytilinaiou³

et al. 2014

WJG

148

108

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Helicobacter pylori (H. pylori) is the main cause of chronic gastritis and a major risk factor for gastric cancer. This pathogen has also been considered a potential trigger of gastric autoimmunity, and in particular of autoimmune gastritis. However, a considerable number of reports have attempted to link H. pylori infection with the development of extra-gastrointestinal autoimmune disorders, affecting organs not immediately relevant to the stomach. This review discusses the current evidence in support or against the role of H. pylori as a potential trigger of autoimmune rheumatic and skin diseases, as well as organ specific autoimmune diseases. We discuss epidemiological, serological, immunological and experimental evidence associating this pathogen with autoimmune diseases. Although over one hundred autoimmune diseases have been investigated in relation to H. pylori, we discuss a select number of papers with a larger literature base, and include Sjögrens syndrome, rheumatoid arthritis, systemic lupus erythematosus, vasculitides, autoimmune skin conditions, idiopathic thrombocytopenic purpura, autoimmune thyroid disease, multiple sclerosis, neuromyelitis optica and autoimmune liver diseases. Specific mention is given to those studies reporting an association of anti-H. pylori antibodies with the presence of autoimmune disease-specific clinical parameters, as well as those failing to find such associations. We also provide helpful hints for future research.

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Section: Discussionmentioning

confidence: 99%

“…Some authors described marked improvement and/or remission of the refractory disease following proven bacteria eradication [19,20], whereas others consider the approach to be of no benefit to psoriatic individuals [21]. For example, Dauden et al [21] observed no improvement of psoriatic lesions, despite successful H. pylori eradication. Potential cutaneous pathology of H. pylori remains unknown, but it may be associated with a superantigen effect of the bacteria or their products, increased mucosal permeability of the gastrointestinal tract, various autoimmune mechanisms, or impairment of vascular integrity [2].…”

Section: Discussionmentioning

confidence: 99%

Psoriasis vulgaris and digestive system disorders: is there a linkage?

Pietrzak

Jastrzębska²,

Chodorowska³

et al. 2010

Folia Histochem Cytobiol.

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Psoriasis is well-known immune-mediated skin disease often associated with co-morbidities, including dyslipidaemia and obesity. Few reports imply that the disease might be also related to pathology of mucosal surfaces, especially that of the digestive system. The authors present a case of psoriasis and concurrent digestive system abnormalities, and review the literature regarding the topic. A 40-year-old man suffered from an exacerbation of exudative psoriasis for about 6 months. Topical antipsoriatics proved ineffective and the disease gradually progressed to a severe disseminated form. Subsequent detailed examinations revealed persistent gastroduodenitis due to H. pylori infection, pancreatic dysfunction and fatty change of the liver, although the patient denied any gastrointestinal symptoms. As a result appropriate treatment of the diagnosed digestive system disorders was added to topical antipsoriatic therapy. Within 2 weeks of treatment clinical symptoms and laboratory signs showed a marked trend to normalisation. The presented medical history seems to suggest that there may be some kind of interplay between psoriasis and digestive system disorders.

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Association of Helicobacter pylori Infection With Psoriasis and Lichen Planus: Prevalence and Effect of Eradication Therapy

Cited by 21 publications

References 4 publications

Microbiological Findings in Subjects With Asymptomatic Oral Lichen Planus: A Cross‐Sectional Comparative Study

Microbiological Findings in Subjects With Asymptomatic Oral Lichen Planus: A Cross‐Sectional Comparative Study

Helicobacter pyloriand autoimmune disease: Cause or bystander

Psoriasis vulgaris and digestive system disorders: is there a linkage?

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