Association ofAPOEGenotype with Bone Mineral Density in Men and Women: The Dong-gu and Namwon Studies

Abstract

Many studies have investigated relationships between APOE genotype and bone mineral density (BMD). However, the results of these studies have been inconsistent. Few studies have been carried out in Asian populations. We studied the relationship of the APOE gene polymorphism and BMD in two large population-based studies. The datasets included the Dong-gu Study (3575 men and 5335 women) and the Namwon Study (2310 men, 3512 women). Lumbar spine and femoral neck BMD were measured by dual-energy X-ray absorptiometry. APOE genotypes were analyzed by polymerase chain reaction–restriction fragment length polymorphism. The APOE genotypes were classified into APOE E2 (E2/E2 and E2/E3), APOE E3 (E3/E3), and APOE E4 (E3/E4 and E4/E4). The genotype distribution of the study population was in Hardy-Weinberg equilibrium. There were no significant differences among APOE genotype groups in lumbar and femoral neck BMD in either cohort. Our data do not support the hypothesis that the APOE genotype is associated with BMD.

Association of Bone Turnover Markers With Apoe4 Allele in Subjects With Osteoporotic Fractures.

“…In the present study we found the APOE genotypes E2E2, E2E3, E3E3, E3E4 and E4E4 with frequency of 0.8, 6, 69, 21 & 3% respectively in cases and 0, 8, 73, 15 & 3% respectively in controls; and the allele frequency of E2, E3 and E4 was found to be 3.6, 82.5 and 13.9% respectively in cases and 4, 85 and 10.9% respectively in controls. This genotype frequency is in accordance with the previous reports (Kim et al, 2016). Though we found high frequency of E4 allele in cases (13.9%) when compared to control (10.9%), the difference was not statistically significant.…”

“…Simultaneously, there have been reports showing no association of E4 allele with osteoporosis since its first report by Booth et al, which included 888 subjects from Framingham heart study (Booth et al, 2000). The recent study that claims to have used largest sample size of 14,732 subjects, also could not find the association of APOE4 with osteoporosis (Kim et al, 2016).…”

Modulation of Bone Mineral Density and Its Response to Menopausal Hormone Therapy according to the Apolipoprotein E Genotype in Postmenopausal Korean Women

“…A Japanese study in older women also reported a decrease in spine BMD [ 8 ]. A study performed in community-dwelling women who were 45 years of age and older and living in a South-Western Korean province reported no difference in BMDs based on the ε4 allele at the spine and femoral neck [ 17 ]. The current study was conducted at a single tertiary hospital in Seoul, Korea, and included younger postmenopausal women with menopausal syndrome.…”

Role of estrogen in women's Alzheimer's disease risk as modified by APOE

“…[204][205][206][207] Several large studies that included males and females did not find an association of APOE genotype with bone mineral density (BMD). [208][209][210][211][212] However, targeted studies of postmenopausal woman find APOE4 carriers have lower BMD [213][214][215][216][217] or higher hip fracture risk, 218 although there have been null findings. 219 A meta-analysis found APOE4 to be associated with significantly lower BMD in trochanteric and lumbar spine, predominantly in females.…”

“…In particular, significant bone loss occurs at the onset of menopause and diminishes in later life with HT 204–207 . Several large studies that included males and females did not find an association of APOE genotype with bone mineral density (BMD) 208–212 . However, targeted studies of postmenopausal woman find APOE4 carriers have lower BMD 213–217 or higher hip fracture risk, 218 although there have been null findings 219 .…”