Association of human leukocyte antigen polymorphism with outcomes of hepatitis B virus infection

Ramezani, Amitis; Roshan, Mohammad Reza Hasanjani; Kalantar, Enayatollah; Eslamifar, Ali; Banifazl, Mohammad; Taeb, Jaleh; Aghakhani, Arezoo; Gachkar, Latif; Velayati, Ali Akbar

doi:10.1111/j.1440-1746.2008.05482.x

Cited by 41 publications

(32 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…T-cell response (Diepolder et al 1998;Futagawa et al 2006). In a study by Ramezani et al (2008) in Iran, the presence of HLA-DR13 was protective against chronic hepatitis, and HLA class I A33 was associated with the onset of chronic disease, a finding in agreement with many similar studies, including the present one. In the Iranian study the development of chronic disease was associated with age, HBeAg, and anti-HBe.…”

Section: Discussionsupporting

confidence: 93%

Role of HLA Allele Polymorphism in Chronic Hepatitis B Virus Infection and HBV Vaccine Sensitivity in Patients from Eastern Turkey

Albayrak

Ertek²,

Taşyaran³

et al. 2010

Biochem Genet

View full text Add to dashboard Cite

Human leukocyte antigen (HLA) alleles have been associated with the clinical outcomes of hepatitis B virus (HBV) infection, which range from spontaneous recovery to hepatocellular carcinoma. In this study involving subjects from eastern Turkey, the frequencies of HLA-B35, HLA-CW4, HLA-DQ2, and HLA-DQ8 were markedly higher in the chronic HBV group than those in the spontaneously recovered group; the frequencies of HLA-A11 and HLA-A24 in the nonresponsive HBV vaccine group were markedly higher than those in the responsive HBV vaccine group; and the frequency of HLA-CW6 in the nonresponsive HBV vaccine group was significantly lower than in the responsive group. A complete understanding of HLA types associated with the progression to chronic HBV infection and their effects within the cell at the molecular level will be an important contribution in the development of new HBV vaccines and new treatment strategies for chronic HBV infection.

show abstract

Section: Discussionsupporting

confidence: 93%

Role of HLA Allele Polymorphism in Chronic Hepatitis B Virus Infection and HBV Vaccine Sensitivity in Patients from Eastern Turkey

Albayrak

Ertek²,

Taşyaran³

et al. 2010

Biochem Genet

View full text Add to dashboard Cite

show abstract

“…We have demonstrated the association of specific HLA alleles susceptible to HBV-related HCC, whereas most previous studies have focused on susceptibility and resistance to chronic hepatitis B (Han et al, 2005). Ramezani et al (2008) showed that HLA-A*33 is strongly related to susceptibility to hepatitis B persistence and that HLA-DRB*13 is strongly related to protection against hepatitis B persistence in a cross-section of the Iranian population. S.R.S.…”

Section: Discussionmentioning

confidence: 78%

Evaluation of a histocompatibility antigen related to hepatitis B virus in patients with hepatocellular carcinoma in the western Brazilian Amazon

Chalub

Silva²,

Silva³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Hepatocellular carcinoma is an infection of variable incidence that can be caused by hepatitis B virus (HBV), which is endemic in the Amazon region. The diagnosis of HBV can be performed through the use of serum markers such as the hepatitis B surface antigen. The chronic HBV can cause mutagenesis and carcinogenesis, being the susceptibility of infection due to allele human leukocyte antigen (HLA). Thus, we evaluated the clinical, molecular and laboratory profile (histocompatibility complex) of HBV in 22 patients with hepatocellular Evaluation of HLA in patients with hepatocellular carcinoma carcinoma in Amazonia, including 18 males and 4 females, using a blood sample for generic HLA class II. The results showed increased frequency of disease evolution in adults between 25 and 64 years old, who comprised 19 of the 22 patients studied. Most patients (16/22) presented high levels of alpha-fetoprotein and transaminases (14/22). The most common HLA alleles were DRB1*04 (8/44), DRB1*08 (9/44), DRB*03 (16/44), and DQB1*04 (9/44). When we compared specific phenotype frequencies of HLA-DRB1* between patients and controls, we found that patients had a significantly higher frequency of allele DRB1*08 and a significantly lower frequency of DRB1*07 and DRB1*12 compared to previous studies on Asian and Amazonian populations suggesting ethnic differences. We suggest that alleles HLA-DRB*08, HLA-DRB*03 and HLA-DQB1*04 may be risk factors for hepatocellular carcinoma in Amazon.

show abstract

“…8 Specifically, the implicated alleles have been previously linked with autoimmune conditions, many of which are also established or hypothesized risk factors for NHL, including systemic lupus erythematosus (HLA-DRB1*0301, HLA-B*0801), Sjogren syndrome (HLA-DRB1*0301, HLA-B*0801), celiac disease (HLA-DRB1*0301), rheumatoid arthritis (HLA-DRB1*0101 and *0401), and type 1 diabetes (HLA-DRB1*0401 and *0301). 9 Previous risk reductions have also been reported for several other diseases in association with HLA-DRB1*13 alleles, including autoimmune conditions (eg, rheumatoid arthritis 10 and multiple sclerosis 11 ) and infectious diseases (eg, hepatitis B infection, [12][13][14] hepatitis C infection, 15,16 and human papillomavirus 17 ). Ours is the first such report for NHL.…”

Section: Zygosity (Heterozygote Advantage)mentioning

confidence: 96%

Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology

Wang

Abdou

Morton

et al. 2010

Blood

View full text Add to dashboard Cite

Association of human leukocyte antigen polymorphism with outcomes of hepatitis B virus infection

Cited by 41 publications

References 14 publications

Role of HLA Allele Polymorphism in Chronic Hepatitis B Virus Infection and HBV Vaccine Sensitivity in Patients from Eastern Turkey

Role of HLA Allele Polymorphism in Chronic Hepatitis B Virus Infection and HBV Vaccine Sensitivity in Patients from Eastern Turkey

Evaluation of a histocompatibility antigen related to hepatitis B virus in patients with hepatocellular carcinoma in the western Brazilian Amazon

Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology

Contact Info

Product

Resources

About