Association of hepatitis C virus infection and malnutrition-inflammation complex syndrome in maintenance hemodialysis patients

Abstract

MHD patients with active HCV infections have more severe MICS-associated metabolic and physiological disease than MHD patients without active HCV infection.

The Effect of Hepatitis C Virus Infection on Insulin Resistance in Chronic Hemodialysis Patients

“…In our study WBC's and platelets were significantly lower in group 1 than group 2. These results are in agreement with Tsai et al, [11] and can be due to replication of the HCV virus in bone marrow, splenic sequestration and immune mediated [14] . Hemoglobin was higher in group 1 and these results are in agreement with Alsaran et al, [15] and can be explained by that hepatic inflammation induces erythropoietin production by liver cells and also due to altered iron metabolism [16] .…”

“…As regard age and sex distribution in our study there were no significant differences among group 1 and group 2, these results were in agreement with Tsai et al, [11] and Ozdemir et al, [12] . In comparison of clinical data of group 1 and group 2, therewere no statistical significant differences between the two groups regarding height, systolic blood pressure and diastolic blood pressure.…”

“…In comparison of clinical data of group 1 and group 2, therewere no statistical significant differences between the two groups regarding height, systolic blood pressure and diastolic blood pressure. Dialysis duration was longer significantly in group 1 with mean duration 7.93 ± 5.25 years and these results were in agreement with Tsai et al, [11] and Ozdemir et al, [12] . This can be explained by the longer the dialysis duration the higher the chance of nosocomial transmission of HCV due to sharing items between patients, contamination of dialysis machines, contaminated gloves used by working nurses and lack of proper sterilization of machines after each dialysis session [13] .…”

Quality of Life in Hepatitis C Virus Seropositive Hemodialysis Patients

“…Although there have been many advances in the treatment of end-stage renal disease (ESRD), mortality rates for ESRD patients remain several times higher than those of age-matched controls, and patients with ESRD continue to have significant impairments in quality of life (QOL), quality of life is related with morbidity and mortality in hemodialysis patients, and it is suggested that QOL should be considered in the regular monitoring of dialysis patients [4]. Hemodialysis patients infected with HCV often have poor shortterm clinical outcome, greater mortality, greater hospitalization rate, more significant protein-energy malnutrition and worse health -related quality of life [5].…”

“…Although there have been many advances in the treatment of end-stage renal disease (ESRD), mortality rates for ESRD patients remain several times higher than those of age-matched controls, and patients with ESRD continue to have significant impairments in quality of life (QOL), quality of life is related with morbidity and mortality in hemodialysis patients, and it is suggested that QOL should be considered in the regular monitoring of dialysis patients [4]. Hemodialysis patients infected with HCV often have poor shortterm clinical outcome, greater mortality, greater hospitalization rate, more significant protein-energy malnutrition and worse health -related quality of life [5].The prevalence of HCV infection in patients undergoing dialysis is persistently greater than that in the general population, being endemic in hemodialysis units around the world predominantly in Mediterranean and developing countries of the Middle and Far East [6]. It was well demonstrated that HCV had a negative impact on health-related quality of life (HRQOL).…”