Association of Helicobacter pylori with Chronic Kidney Diseases: A Meta-Analysis

Abstract

The estimated prevalence of H. pylori in patients with non-dialysis-dependent kidney diseases is 53%. This study does not support the association between H. pylori infection and non-dialysis-dependent kidney diseases nor CKD.

Helicobacter pylori infection and extragastric diseases in 2017

“…The pooled risk RR of ESRD in patients with H. pylori was 0.61 (0.03‐12.20), but these data were limited to only two cohort studies with contradictory results and different selection criteria. The meta‐analysis of nine eligible cross‐sectional studies conducted by Wijarnpreecha et al . did not support the association between H. pylori infection and nondialysis‐dependent kidney diseases (OR: 1.20, 0.73‐1.97) nor chronic kidney diseases (OR: 1.00, 0.58‐1.71).…”

Chronic Kidney Disease and H. pylori Prevalence: A Significant Association?

“…In summary, re-analysis of the data reported by Wijarnpreecha et al [1] using alternate and arguably superior statistical methods would reveal a significant correlation between CKD and Hp prevalence.…”

“…The Wijarnpreecha et al [1] study, entitled ''Association of Helicobacter pylori with Chronic Kidney Diseases: A Meta-Analysis,'' published in Digestive Diseases and Sciences, investigated the relationship between H. pylori infection and the incidence of chronic kidney disease (CKD) and non-dialysis-dependent kidney disease. Wijarnpreecha et al reported that the association in question was not significant.…”

“…They analyzed nine cross-sectional studies using 95% confidence intervals (CI) and odds ratio (OR) to investigate association between H. pylori infection and CKD. The prevalence of odds ratio (POR) method was used to explain the prevalence of H. pylori in patients with and without kidney disease, illustrated by two graphs [1]. In cross-sectional studies, the POR can be computed using the same ad/bc formula (POR is a measure of the association between the two factors in the 2 9 2 table).…”

Helicobacter pylori and extragastric diseases

“…Another meta‐analysis by the same authors included nine cross‐sectional studies and estimated a pooled OR of 1.20 (95% CI: 0.73, 1.97) for H. pylori positivity in patients with non‐dialysis‐dependent kidney disease when compared to controls. The meta‐analysis was then limited to studies evaluating the risk of H. pylori in chronic kidney disease (CKD) and showed a pooled OR of 1.00 (95% CI: 0.58, 1.71), not significant for the association …”