Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters

Panezai, Jeneen; Altamash, Mohammad; Engström, Per‐Erik; Larsson, Anders

doi:10.1155/2020/6450742

Cited by 12 publications

(14 citation statements)

References 44 publications

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“…The decrease in RANKL observed in literature was attributed to immature osteoblasts and an increase in the number of osteoclasts (20). Some authors also found that serum RANKL levels were lower and OPGs were higher in diabetic patients compared to nondiabetics and prediabetics (21). The highest serum concentration of RANKL was associated with a significantly increased risk of developing type 2 diabetes (22).…”

Section: Discussionmentioning

confidence: 95%

The Role of RANKL and FGF23 in Assessing Bone Turnover in Type 2 Diabetic Patients

et al. 2021

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Section: Discussionmentioning

confidence: 95%

The Role of RANKL and FGF23 in Assessing Bone Turnover in Type 2 Diabetic Patients

et al. 2021

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“…However, this study was conducted on a small sample ( n = 60), with adiposity being only measured with anthropometric variables, with no consideration for albumin correction. Other studies in the general population have demonstrated that serum fructosamine levels were associated negatively with fat mass [ 43 ], but no association was observed with waist circumference, fat mass, liver fat, and fat distribution [ 39 , 43 , 54 ]. Therefore, the literature generally shows contrasting results regarding the associations between fructosamine and adiposity.…”

Section: Discussionmentioning

confidence: 99%

“…Some inverse associations were also noticed between fructosamine concentrations and inflammation (adiponectin and IL-6) throughout pregnancy, without being independent of ppBMI. A cross-sectional analysis conducted in the Pakistani general population, aiming to investigate the correlations between glycated proteins and periodontal and systemic inflammation also demonstrated inverse associations, as sixteen inflammatory proteins were found to correlate inversely with fructosamine [ 39 ]. The inverse associations observed between uncorrected fructosamine and inflammatory measurements could reflect the negative associations between albumin and inflammation, as all significant correlations were lost after albumin correction.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, by the formation of fructosamine, glycemic imbalance could lead to inflammation. On the other hand, pro-inflammatory cytokines such as interleukin-6 (IL-6) have been suggested to contribute to the overall development of insulin resistance [ 39 ] and could have a role in the etiology of GDM [ 40 ]. Even though the links between abdominal fat accumulation, adipose tissue dysfunction, adiposity-related systemic inflammation, and insulin resistance have been well demonstrated [ 41 , 42 ], no study has ever investigated the associations between fructosamine concentrations and abdominal adiposity or inflammation in pregnancy.…”

Section: Introductionmentioning

confidence: 99%

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Trimester-Specific Serum Fructosamine in Association with Abdominal Adiposity, Insulin Resistance, and Inflammation in Healthy Pregnant Individuals

et al. 2022

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This study aimed to (1) characterize the variations in serum fructosamine across trimesters and according to pre-pregnancy BMI (ppBMI), and (2) examine associations between fructosamine and adiposity/metabolic markers (ppBMI, first-trimester adiposity, leptin, glucose homeostasis, and inflammation measurements) during pregnancy. Serum fructosamine, albumin, fasting glucose and insulin, leptin, adiponectin, interleukin-6 (IL-6), and C-reactive protein (CRP) concentrations were measured at each trimester. In the first trimester, subcutaneous (SAT) and visceral (VAT) adipose tissue thicknesses were estimated by ultrasound. In the 101 healthy pregnant individuals included (age: 32.2 ± 3.5 y.o.; ppBMI: 25.5 ± 5.5 kg/m2), fructosamine concentrations decreased during pregnancy whereas albumin-corrected fructosamine concentrations increased (p < 0.0001 for both). Notably, fructosamine concentrations were inversely associated with ppBMI, first-trimester SAT, VAT, and leptin (r = −0.55, r = −0.61, r = −0.48, r = −0.47, respectively; p < 0.0001 for all), first-trimester fasting insulin and HOMA-IR (r = −0.46, r = −0.46; p < 0.0001 for both), and first-trimester IL-6 (r = −0.38, p < 0.01). However, once corrected for albumin, most of the correlations lost strength. Once adjusted for ppBMI, fructosamine concentrations were positively associated with third-trimester fasting glucose and CRP (r = 0.24, r = 0.27; p < 0.05 for both). In conclusion, serum fructosamine is inversely associated with adiposity before and during pregnancy, with markers of glucose homeostasis and inflammation, but the latter associations are partially influenced by albumin concentrations and ppBMI.

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“…Fructosamine (FrAm) is another glycated AGE that has been recognized in RA [74]. Malondialdehyde (MDA) has a positive correlation with FrAm and a negative correlation with glutathione (GSH), closely associated with the formation of FrAm in RA [75].…”

Section: Vascular Complications and Autoimmune Responsementioning

confidence: 99%

AGE/Non-AGE Glycation: An Important Event in Rheumatoid Arthritis Pathophysiology

Monu,

Agnihotri,

Biswas

2021

Inflammation

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Rheumatoid arthritis (RA) is a chronic inflammatory, autoimmune disease that gradually affects the synovial membrane and joints. Many intrinsic and/or extrinsic factors are crucial in making RA pathology challenging throughout the disease. Substantial enzymatic or non-enzymatic modification of proteins driving inflammation has gained a lot of interest in recent years. Endogenously modified glycated protein influences disease development linked with AGEs/non-AGEs and is reported as a disease marker. In this review, we summarized current knowledge of the differential abundance of glycated proteins by compiling and analyzing a variety of AGE and non-AGE ligands that bind with RAGE to activate multi-faceted inflammatory and oxidative stress pathways that are pathobiologically associated with RA-fibroblast-like synoviocytes (RA-FLS). It is critical to comprehend the connection between oxidative stress and inflammation generation, mediated by glycated protein, which may bind to the receptor RAGE, activate downstream pathways, and impart immunogenicity in RA. It is worth noting that AGEs and non-AGEs ligands play a variety of functions, and their functionality is likely to be more reliant on pathogenic states and severity that may serve as biomarkers for RA. Screening and monitoring of these differentially glycated proteins, as well as their stability in circulation, in combination with established pre-clinical characteristics, may aid or predict the onset of RA.KEY WORDS: rheumatoid arthritis (RA); rheumatoid factors (RF); anti-citrullinated peptide antibodies (ACPAs); advanced glycation end-products (AGEs); glyoxal (GO); methylglyoxal (MGO); N-carboxymethyl lysine (CML); reactive oxygen species (ROS); interleukin (IL).

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Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters

Cited by 12 publications

References 44 publications

The Role of RANKL and FGF23 in Assessing Bone Turnover in Type 2 Diabetic Patients

The Role of RANKL and FGF23 in Assessing Bone Turnover in Type 2 Diabetic Patients

Trimester-Specific Serum Fructosamine in Association with Abdominal Adiposity, Insulin Resistance, and Inflammation in Healthy Pregnant Individuals

AGE/Non-AGE Glycation: An Important Event in Rheumatoid Arthritis Pathophysiology

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