Association of genetic polymorphisms in ADH and ALDH2 with risk of coronary artery disease and myocardial infarction: A meta-analysis

Han, Haitang; Wang, Huishan; Yin, Zhihua; Jiang, Hui; Fang, Minhua; Han, Jingsong

doi:10.1016/j.gene.2013.05.002

Cited by 46 publications

(31 citation statements)

References 29 publications

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“…Prior studies have reported racial/ethnic differences in the magnitude of the association between habitual alcohol consumption and risk of cardiovascular events 17, 50 which may involve ethnic variations in the prevalence of genetic polymorphisms related to alcohol metabolism, 51 cultural differences in past drinking, current drinking patterns and associations between drinking patterns and other health risk factors and health problems. 52 Future studies are needed to evaluate whether there is any racial/ethnic variation in the acute effects of alcohol intake on cardiovascular risk, and whether genetic differences may play a role.…”

Section: Discussionmentioning

confidence: 99%

Alcohol and Immediate Risk of Cardiovascular Events

et al. 2016

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Background Although considerable research describes the cardiovascular effects of habitual moderate and heavy alcohol consumption, the immediate risks following alcohol intake have not been well characterized. Based on its physiological effects, alcohol may have markedly different effects on immediate and long-term risk. Methods and Results We searched CINAHL, Embase, and PubMed from inception to March 12 2015, supplemented with manual screening for observational studies assessing the association between alcohol intake and cardiovascular events in the following hours and days. We calculated pooled relative risks (RRs) and 95% confidence intervals (CIs) for the association between alcohol intake and myocardial infarction (MI), ischemic stroke (IS) and hemorrhagic stroke (HS) using DerSimonian and Laird random-effects models to model any alcohol intake or dose-response relationships of alcohol intake and cardiovascular events. Among 1056 citations and 37 full-text articles reviewed, 23 studies (29457 participants) were included. Moderate alcohol consumption was associated with an immediately higher cardiovascular risk that was attenuated after 24 hours, and even protective for MI and HS (≈2–4 drinks: RR=30% lower risk), and protective against IS within one week (≈6 drinks: 19% lower risk). In contrast, heavy alcohol drinking was associated with higher cardiovascular risk in the following day (≈6–9 drinks: RR=1.3–2.3) and week (≈19–30 drinks: RR=2.25–6.2). Conclusions There appears to be a consistent finding of an immediately higher cardiovascular risk following any alcohol consumption but by 24 hours, only heavy alcohol intake conferred continued risk.

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Section: Discussionmentioning

confidence: 99%

Alcohol and Immediate Risk of Cardiovascular Events

et al. 2016

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“…[35][36][37][38][39] Takeuchi et al 40 recently identified the genetic locus of ALDH2*2 (rs671) as the strongest predictor for myocardial infarction in a genome-wide association study in Japanese. ALDH2 also plays an essential role in the bioactivation of GTN used widely for the treatment of ischemic heart disease.…”

Section: Discussionmentioning

confidence: 99%

East Asian Variant of Aldehyde Dehydrogenase 2 Is Associated With Coronary Spastic Angina

et al. 2015

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Background-Coronary spastic angina (CSA) is a common disease among East Asians, including Japanese. The prevalence of alcohol flushing syndrome associated with deficient activity of the variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians. We examined whether CSA is associated with the ALDH2*2 genotype in Japanese. Methods and Results-The study subjects consisted of 202 patients in whom intracoronary injection of acetylcholine was performed by angiography on suspicion of CSA (119 men and 83 women; mean age, 66.2±11.4 years). They were divided into CSA (112 patients) and control groups (90 patients). ALDH2 genotyping was performed by the direct application of the TaqMan polymerase chain reaction system on dried whole blood. Clinical and laboratory data were examined using conventional methods. The frequencies of male sex, ALDH2*2 genotype carriers, alcohol flushing syndrome, tobacco smoking, and the plasma level of uric acid were higher (P<0. 001, P<0.001, P<0.001, P<0.001, and P=0.007, respectively) and the plasma high-density lipoprotein cholesterol levels were lower (P<0.001) in the CSA group than in the control group. The multivariable logistic regression analysis revealed that ALDH2*2 genotype and smoking were significantly associated with CSA (P<0.001 and P=0.024, respectively). Conclusions-East Asian variant ALDH2*2 genotypes and, hence, deficient ALDH2 activity were associated with CSA in Japanese. These data support further investigation of treatment targeting aldehydes for CSA. (Circulation.

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“…23 However, the situation is complex. A recent meta-analysis found that Chinese and Korean carriers of the ALDH2*504lys allele had an almost 30% increased risk of cardiovascular disease but that Japanese carriers seemed to be at no increased risk.…”

Section: Long-term Pattern Of Alcohol Use and Risk Of MImentioning

confidence: 99%

Patterns of Alcohol Consumption and Myocardial Infarction Risk

et al. 2014

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Background— Although moderate alcohol use is associated with protection against myocardial infarction (MI), it is not known whether this effect is generalizable to populations worldwide. It is also uncertain whether differences in the pattern of alcohol use (and in particular heavy episodic consumption) between different regions negate any beneficial effect. Methods and Results— We included 12 195 cases of first MI and 15 583 age- and sex-matched controls from 52 countries. Current alcohol use was associated with a reduced risk of MI (compared with nonusers: adjusted odds ratio, 0.87; 95% confidence interval, 0.80–0.94; P =0.001); however, the strength of this association was not uniform across different regions (region-alcohol interaction P <0.001). Heavy episodic drinking (≥6 drinks) within the preceding 24 hours was associated with an increased risk of MI (odds ratio, 1.4; 95% confidence interval, 1.1–1.9; P =0.01). This risk was particularly elevated in older individuals (for age >65 years: odds ratio, 5.3; 95% confidence interval, 1.6–18; P =0.008). Conclusions— In most participants, low levels of alcohol use are associated with a moderate reduction in the risk of MI; however, the strength of this association may not be uniform across different countries. An episode of heavy drinking is associated with an increased risk of acute MI in the subsequent 24 hours, particularly in older individuals.

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Association of genetic polymorphisms in ADH and ALDH2 with risk of coronary artery disease and myocardial infarction: A meta-analysis

Cited by 46 publications

References 29 publications

Alcohol and Immediate Risk of Cardiovascular Events

Alcohol and Immediate Risk of Cardiovascular Events

East Asian Variant of Aldehyde Dehydrogenase 2 Is Associated With Coronary Spastic Angina

Patterns of Alcohol Consumption and Myocardial Infarction Risk

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