Association of Dyslipidemia and Glycated Haemoglobin in Gestational Diabetes Mellitus

Abstract

Background: GDM is a condition where there is an onset of carbohydrate intolerance during pregnancy. In this condition many changes will take place in carbohydrate metabolism and other metabolic pathways especially in lipid metabolism. These metabolic changes associated with insulin resistance and dyslipidemia. We have aim to study the association between dyslipidemia and glycated haemoglobin. Materials and Methods: The study was conducted in 80 pregnant women of rural population of Puducherry in two groups. Group 1 includes 40 newly diagnosed GDM patients by DIPSI and Group II with 40 normal pregnant women, age group were between 20 to 40 years. Fasting blood glucose, 2-hour post glucose and lipid profile were estimated by auto analyzer. HbA1c was analysis by HPLC method. For comparisons of means student t-test was used to determine the significance between GDM and controls. Results: There was statistically significant difference in lipid profiles (P = 0.05), HDL (P = 0.04), VLDL (P = 0.00), LDL (P = 0.04) HDL (P = 0.04) in GDM groups. HbA1c (P = 0.02) levels were statistically significance with GDM pregnant women. There was no statically significant difference between FG (P = 0.23), TG (P = 0.30) and lipids profiles ratio levels in GDM. Conclusion: This study was found to be associations between lipids profiles and Gestational diabetes mellitus in GDM groups.

Glycated Hemoglobin and Lipid Profile Association Among Pregnant Women in Saudi Arabian Population

“…Furthermore, Khan et al (22) found that the value of FBG was 112 ± 8.70 mg/dL in GDM groups compared to 87 ± 6.90 mg/ dL in healthy pregnant women (P < 0.001). Contrarily, Lenin et al (19) indicated no significant difference in FBG value among non-GDM and GDM groups among an Indian population. They reported an FBG measure of 72.45± 7.23 mg/dL and 74.3 ± 9.18 mg/dL (P = 0.23) in the 2 groups, respectively.…”

“…Hyperlipidemia typically occurs during normal pregnancy and alterations in lipid profile is known to occur in GDM (11). Significantly elevated levels of HbA1c in GDM and its relation to lipid profile were reported by several researchers (19,22,23). McGrowder at al indicated HbA1c concentration was higher in women with GDM (P = 0.001); in addition, they found that TC and triglycerides were significantly high in these women (P=0.039 for TC and P = 0.033 for TG).…”

“…Several studies demonstrated marked alterations in values of plasma lipid profile and concentrations of lipoprotein (17)(18)(19). The current study was designed to investigate the lipid profile and glucose tolerance in GDM women and compare it with normal pregnant women.…”

Comparison of Serum Lipid Profile between Gestational Diabetes Mellitus and Pregnant Women with Normal Glucose Tolerance

“…Fasting Lipid profile and GDM have been shown to be the important predic-Journal of Biosciences and Medicines tors for maternal metabolic disturbances including dyslipidemia, hypertension and cardiovascular disease [12]. Moreover, pre-pregnancy BMI was found to have a far greater effect on IR in pregnancy in Asian women than Caucasians [32].…”

“…Therefore serum lipid profile is important in the assessment of blood glucose levels. The abnormalities of carbohydrate metabolism observed in GDM may affect other metabolic pathways especially lipid metabolism [12]. IR which is one of the primary defects in majority of GDM presumed to have important relationship with dyslipidaemia in pregnancy and future cardio-metabolic risk [13].…”