2021
DOI: 10.1177/0300060521999555
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Association of dyslipidaemia with osteoporosis in postmenopausal women

Abstract: Objective To assess the association of dyslipidaemia with osteoporosis in postmenopausal women. Methods Data from 160 postmenopausal women with newly diagnosed osteoporosis (osteoporosis group) and 156 healthy controls (control group) were retrospectively reviewed from 2016 to 2020. The primary outcomes were laboratory values assessed by a multivariate binary logistic regression model. Results Factors that greatly increased the risk of being in the osteoporosis group included high low-density lipoprotein (LDL)… Show more

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Cited by 12 publications
(11 citation statements)
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“…A retrospective study has been shown that dyslipidemia in postmenopausal women is positively associated with OP progression [ 5 ]. Furthermore, hypercholesterolemia or high-cholesterol diets have been reported to reduce bone strength and enhance the potential risks of bone fracture and OP [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…A retrospective study has been shown that dyslipidemia in postmenopausal women is positively associated with OP progression [ 5 ]. Furthermore, hypercholesterolemia or high-cholesterol diets have been reported to reduce bone strength and enhance the potential risks of bone fracture and OP [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…Fractures are associated with osteoporosis, and patients with PD are at a significantly higher risk of developing osteoporosis [ 25 ]. Furthermore, osteoporosis is caused by non-communicable diseases, such as ischemic heart disease, dyslipidemia, and diabetes mellitus [ 26 28 ], and patients with diabetes mellitus [ 29 ] or cancer [ 30 ] have a higher risk of falls. We found that osteoporosis significantly increased the risk of fractures, although non-communicable diseases did not significantly influence the risk of injuries.…”
Section: Discussionmentioning
confidence: 99%
“…We have not identified any relevant research documenting changes in LCAT in patients with NAFLD and osteoporosis, but studies in mouse models have shown that dysfunctional and/or disordered HDL can affect bone mass in several different ways. Preclinical experiments in rodent models mostly show that HDL content is positively correlated with bone mass (53, 54), and clinical trials in postmenopausal women have reached a similar conclusion (55,56). It has been shown that HDL is closely related to bone metabolism and that HDL can transport cholesterol from extrahepatic tissues to the liver for further metabolism (57).…”
Section: Hdl Inhibits Osteoclast Production and Induces Osteoclast Ap...mentioning
confidence: 99%