Association of dietary factors with severity of coronary artery disease

Mahalle, Namita; Garg, MK; Naik, Sadanand S; Kulkarni, M.S.

doi:10.1016/j.clnesp.2016.06.004

Cited by 21 publications

(16 citation statements)

References 39 publications

(16 reference statements)

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“…Pharmacological doses of nicotinic acid impact lipid profile by increasing HDL-C and reducing triglycerides, LDL-C and lipoprotein (a) [88]. Moreover, a lower dietary intake of the vitamins niacin, riboflavin thiamine, B6 and vitamin C has been associated with an increased severity of coronary disease [89]. However, the relationship between niacin dietary intake and HDL-C has not been assessed elsewhere, to our knowledge.…”

Section: Discussionmentioning

confidence: 95%

Dietary Intakes Are Associated with HDL-Cholesterol in Survivors of Childhood Acute Lymphoblastic Leukaemia

et al. 2019

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Survivors of childhood acute lymphoblastic leukemia (cALL) are at high risk of developing dyslipidemia, including low HDL-cholesterol (HDL-C). This study aimed to examine the associations between food/nutrient intake and the levels of HDL-C in a cohort of children and young adult survivors of cALL. Eligible participants (n = 241) were survivors of cALL (49.4% boys; median age: 21.7 years old) recruited as part of the PETALE study. Nutritional data were collected using a validated food frequency questionnaire. Fasting blood was used to determine participants’ lipid profile. Multivariable logistic regression models were fitted to evaluate the associations between intakes of macro- and micronutrients and food groups and plasma lipids. We found that 41.3% of cALL survivors had at least one abnormal lipid value. Specifically, 12.2% had high triglycerides, 17.4% high LDL-cholesterol, and 23.1% low HDL-C. Low HDL-C was inversely associated with high intake (third vs. first tertile) of several nutrients: proteins (OR: 0.27, 95% CI: 0.08–0.92), zinc (OR: 0.26, 95% CI: 0.08–0.84), copper (OR: 0.34, 95% CI: 0.12–0.99), selenium (OR: 0.17, 95% CI: 0.05–0.59), niacin (OR: 0.25, 95% CI: 0.08–0.84), riboflavin (OR: 0.31, 95% CI: 0.12–0.76) and vitamin B12 (OR: 0.35, 95% CI: 0.13–0.90). High meat consumption was also inversely associated (OR: 0.28, 95% CI: 0.09–0.83) with low HDL-C while fast food was positively associated (OR: 2.41, 95% CI: 1.03–5.63) with low HDL-C. The role of nutrition in the development of dyslipidemia after cancer treatment needs further investigation.

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“…Furthermore, it is previously shown that low consumption of protein and minerals (e.g. manganese) and high consumption of carbohydrate and fat is associated with having more severe CAD (30).…”

Section: Discussionmentioning

confidence: 99%

Dietary protein is the strong predictor of coronary artery disease; a data mining approach

Soflaei

Shamsara

Sahranavard

et al. 2020

Preprint

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Backgrounds: Coronary artery disease (CAD) is the major cause of mortality and morbidity globally. Diet is known to contribute to CAD risk, and the dietary intake of specific macro- or micro-nutrients might be potential predictors of CAD risk. Machine learning methods may be helpful in the analysis of the contribution of several parameters in dietary including macro- and micro-nutrients to CAD risk. Here we aimed to determine the most important dietary factors for predicting CAD.Methods: A total of 273 cases with more than 50% obstruction in at least one coronary artery and 443 healthy controls who completed a food frequency questionnaire (FFQ) were entered into the study. All dietary intakes were adjusted for energy intake. The QUEST method was applied to determine the diagnosis pattern of CAD.Results: A total of 34 dietary variables obtained from the FFQ were entered into the initial study analysis, of these variables 23 were significantly associated with CAD according to t-tests. Of these 23 dietary input variables, adjusted protein, manganese, biotin, zinc and cholesterol remained in the model. According to our tree, only protein intake could identify the patients with coronary artery stenosis according to angiography from healthy participant up to 80%. The dietary intake of manganese was the second most important variable. The accuracy of the tree was 84.36% for the training dataset and 82.94% for the testing dataset.Conclusion: Among several dietary macro- and micro-nutrients , a combination of protein, manganese, biotin, zinc and cholesterol could predict the presence of CAD in individuals undergoing angiography.

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“…With the inclusion of walnuts in the diets of our participants, the dietary intake of carbohydrate, sugar, fiber, potassium, sodium, riboflavin, niacin, vitamin B 6 , folic acid, vitamin B 12 , vitamin A, and cholesterol did not show any meaningful changes. According to previous studies, [34][35][36][37][38][39] increased dietary intake of potassium, fiber, riboflavin, niacin, vitamin B 6 , folic acid, vitamin B 12 , and vitamin A has been associated with reduced cardiometabolic risk factors. The increased dietary intake of carbohydrate, sugar, sodium, and cholesterol has been associated with increased cardiometabolic risk factors.…”

Section: Discussionmentioning

confidence: 99%

The Resulting Variation in Nutrient Intake With the Inclusion of Walnuts in the Diets of Adults at Risk for Type 2 Diabetes: A Randomized, Controlled, Crossover Trial

et al. 2018

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“…Namita et al reported that patients associated with metabolic syndrome had more multivessel involvement (34% vs. 16%, p <0.001) than patients without metabolic syndrome. (7) In our study, most of the patients with metabolic syndrome had single vessel involvement (57.38%). This may be due to mean age, which was more in their study population (60±12.4 SD yrs.…”

Section: The Clinical Profile Of the Patients Studied In This Studymentioning

confidence: 92%

Evaluation of Metabolic Syndrome, Its Correlation With Clinical and Angiographic Profile in Patients With Coronary Artery Disease- A Prospective Study at Tertiary Hospital

Srikanth¹,

Srinivas²,

Otikunta³

et al. 2016

jebmh

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BACKGROUNDCoronary artery disease has a major share for cardiovascular disease in a developing country like India, which is in epidemic proportion. There are number of risk factors for development of coronary artery disease. According to INTERHEART study, there were 9 modifiable risk factors with population attributable risk of 90 percent in men and 94 percent in women. Metabolic syndrome cluster of risk factors, which include insulin resistance, subclinical inflammation, increased future risk of diabetes and coronary artery disease. In south Asian people are increased tendency to develop metabolic syndrome because of their high percentage of body fat, abdominal obesity and insulin resistance. Metabolic syndrome has more mortality and morbidity from CAD. It is desirable identifying this subset of patients, which could improve patient or physician adherence to risk-reducing behaviours or interventions and improve clinical outcomes. There are reports in literature on association inflammatory markers and insulin resistance with severity of disease in CAD. There are few studies, which correlated severity of CAD with SYNTAX score in patients with metabolic syndrome, so in these study prospectively evaluated clinical and angiographic profile in patients with CAD in subset patients with metabolic syndrome, CAD severity was assessed with SYNTAX scoring system and thrombus burden was evaluated.

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“…Several studies were performed to unravel the association between diabetic and obesity complication and those inflammatory markers [6,7].…”

Section: Introductionmentioning

confidence: 99%

Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis

Noureldein

El-Razek

El-Hefnawy³

et al. 2015

Diabetes Research and Clinical Practice

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Association of dietary factors with severity of coronary artery disease

Cited by 21 publications

References 39 publications

Dietary Intakes Are Associated with HDL-Cholesterol in Survivors of Childhood Acute Lymphoblastic Leukaemia

Dietary protein is the strong predictor of coronary artery disease; a data mining approach

The Resulting Variation in Nutrient Intake With the Inclusion of Walnuts in the Diets of Adults at Risk for Type 2 Diabetes: A Randomized, Controlled, Crossover Trial

Evaluation of Metabolic Syndrome, Its Correlation With Clinical and Angiographic Profile in Patients With Coronary Artery Disease- A Prospective Study at Tertiary Hospital

Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis

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