Association of CYP1A1, ACE and p22phox polymorphisms with essential hypertension in postmenopausal women

Lança, Vasco; Coelho, Constança; Pêgo, P; Moreira, Helena; Sardinha, Luís B.; Alcântara, Patrícia Pereira Tavares de; Braz-Nogueira, J.; Monteiro, Cristina P.; Breitenfeld, Luiza; Laires, Maria José; Bicho, Manuel

doi:10.1016/s0895-7061(02)02655-9

Cited by 5 publications

(6 citation statements)

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“…A similar observation was also made, although not discussed, by Moon et al 25 who reported that 55.4% of 6235TT subjects have hypertension, whereas 49.7% of CT/CC subjects have hypertension. Lança et al 28 reported that C allele of CYP1A1 T6325C polymorphism is a risk factor for hypertension in postmenopausal women. A relationship between hypertension and this polymorphism was not detected in other studies.…”

Section: Discussionmentioning

confidence: 99%

Cytochrome P4501A1 genotypes and smoking- and hypertension-related ischemic stroke risk

et al. 2012

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This study aimed to determine whether the coding (A4889G) and noncoding region (T6235C) polymorphisms of the gene coding for cytochrome P4501A1 (CYP1A1), a xenobiotic-metabolizing enzyme responsible for the metabolism of carcinogenic polycyclic aromatic hydrocarbons, are involved in the pathogenesis of ischemic stroke in Turkish population. Study group consisted of 226 ischemic stroke patients and 113 controls. Genotypes were attained by allele-specific polymerase chain reaction (PCR) for A4889G and PCR/restriction fragment length polymorphism analysis for T6235C. Frequency of 6235C allele was significantly lower in patients (0.151) compared with controls (0.226, P = 0.015). Prevalence of hypertension and hypertension-associated ischemic stroke risk was lower for 6235C allele carriers. This allele decreased ischemic stroke risk twofold (adjusted odds ratio = 0.48, P = 0.005). There was almost no difference in 4889G allele frequencies in patients (0.445) and controls (0.425). However, prevalence of hypertension was lower in 4889G allele carriers when compared with the wild-type genotypes. In addition, risk of ischemic stroke for smoker and hypertensive individuals was lower when they have at least one 4889G allele. The present study demonstrated that CYP1A1 genetic variants contribute to interindividual variability in smoking- and hypertension-induced ischemic stroke risk.

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Section: Discussionmentioning

confidence: 99%

Cytochrome P4501A1 genotypes and smoking- and hypertension-related ischemic stroke risk

et al. 2012

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“…Moreover, obesity which is an important component of PCOS has been shown to induce hepatic CYP1A1 expression in animal models [20]. CYP1A1 T6235C polymorphism has been shown to be associated with hypertension and endometrial cancer [21,22], both having obesity as an important risk factor and both are found in women with PCOS in later life .Thus, a possible correlation may exist between PCOS, its late metabolic sequelae and CYP1A1 gene expression.…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphism of CYP1A1 (T6235C) Gene as a Risk Factor for Polycystic Ovary Syndrome

Jain¹,

Priyanka²,

ey³

et al. 2015

Andrology

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Objective: The aim of this study was to test the association of CYP1A1 gene T6235C polymorphism with Polycystic Ovary Syndrome (PCOS). Methods: In a case control study, 100 women with PCOS (Rotterdam criteria) and 100 ages matched healthy controls were enrolled and compared with respect to CYP1A1 T6235C polymorphism. The clinical, biochemical and Sonographic parameters of wild type (TT), heterozygous (TC), and homozygous mutant (CC) genotypes in PCOS women were compared with that in controls. Results: The risk ratio of bearing TC genotype was 1.3327 (p=0.32), and CC genotype was 2.6084 (p=0.14) in women with PCOS on the whole. However in PCOS women with the Sonographic presence of Polycystic Ovaries (PCO), the risk ratio became significant for TC genotype (OR=1.872; p=0.04) but not for CC genotype (OR=4.05; p=0.08). There was also a significant association of TC and CC genotypes with ovarian volume (p=0.000) as well as with waist circumference (p=0.03). However, the Total Testosterone, Fasting Glucose: Insulin ratio, LH: FSH ratio and HDL were insignificantly altered. Conclusion: Both homozygous and heterozygous mutation of CYP1A1 confers an increased susceptibility to develop PCO. The abnormal folliculogenesis and hormone imbalance may be a result of CYP1A1 gene polymorphism due to toxin mediated endocrine disruption which along with other contributory factors may lead to full-fledged polycystic ovary syndrome.

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“…5-10% of women in reproductive age group are affected [1]. The estimated prevalence of polycystic ovaries as diagnosed by ultrasonography in normal population is more than 20% [2][3][4][5][6][7][8][9][10][11][12][13][14][15]. PCOS has been said to be a spectrum disease with asymptomatic polycystic ovaries lying at one end and full fledged syndrome at the other end of the spectrum [4].…”

Section: Introductionmentioning

confidence: 99%

“…PCOS has been said to be a spectrum disease with asymptomatic polycystic ovaries lying at one end and full fledged syndrome at the other end of the spectrum [4]. PCOS has a complex multifactorial etiology in which a number of predisposing genes interact with environmental factors to produce the disease [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. CYP1A1 gene is located at 15q22-q24 and encodes cytochrome P450 enzymes involved in phase I of detoxification pathway.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, obesity which is an important component of PCOS has been shown to induce hepatic CYP1A1 expression in animal models [12]. CYP1A1 T6235C polymorphism has been shown to be associated with hypertension and endometrial cancer [15,27], both having obesity as an important risk factor and both are found in women with PCOS in later life. Thus, a possible correlation may exist between PCOS, its late metabolic sequelae and CYP1A1 gene expression.…”

Section: Introductionmentioning

confidence: 99%

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Genetic polymorphism of CYP1A1 (T6235C) Gene as a Risk Factor for Polycystic Ovary Syndrome

Jain¹

2015

Gynecol Obstet (Sunnyvale)

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Objective: The aim of this study was to test the association of CYP1A1 gene T6235C polymorphism with Polycystic Ovary Syndrome (PCOS). Methods:In a case control study, 100 women with PCOS (Rotterdam criteria) and 100 age matched healthy controls were enrolled and compared with respect to CYP1A1 T6235C polymorphism. The clinical, biochemical and Sonographic parameters of wild type (TT), heterozygous (TC), and homozygous mutant (CC) genotypes in PCOS women were compared with that in controls. Results:The risk ratio of bearing TC genotype was 1.3327 (p=0.32), and CC genotype was 2.6084 (p=0.14) in women with PCOS on the whole. However in PCOS women with the Sonographic presence of polycystic ovaries (PCO), the risk ratio became significant for TC genotype (OR=1.872; p=0.04) but not for CC genotype (OR=4.05; p=0.08). There was also a significant association of TC and CC genotypes with ovarian volume (p=0.000) as well as with waist circumference (p=0.03). However, the Total Testosterone, Fasting Glucose: Insulin ratio, LH: FSH ratio and HDL were insignificantly altered. Conclusion:Both homozygous and heterozygous mutation of CYP1A1 confers an increased susceptibility to develop PCO. The abnormal folliculogenesis and hormone imbalance may be a result of CYP1A1 gene polymorphism due to toxin mediated endocrine disruption which along with other contributory factors may lead to full fledged polycystic ovary syndrome.

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Association of CYP1A1, ACE and p22phox polymorphisms with essential hypertension in postmenopausal women

Cited by 5 publications

References 0 publications

Cytochrome P4501A1 genotypes and smoking- and hypertension-related ischemic stroke risk

Cytochrome P4501A1 genotypes and smoking- and hypertension-related ischemic stroke risk

Genetic Polymorphism of CYP1A1 (T6235C) Gene as a Risk Factor for Polycystic Ovary Syndrome

Genetic polymorphism of CYP1A1 (T6235C) Gene as a Risk Factor for Polycystic Ovary Syndrome

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