Association of Crohn’s disease and latent celiac disease: a case report and review of the literature

Schedel, J; Rockmann, Felix; Bongartz, Tim; Woenckhaus, Matthias; Schölmerich, J; Kullmann, Frank

doi:10.1007/s00384-004-0661-x

Cited by 26 publications

(15 citation statements)

References 24 publications

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“…A previously published review of 8 cases found that CD manifested in atypical locations when in conjunction with a celiac disease diagnosis, however our study shows no significant difference in CD location in the presence of celiac disease. 27 The lack of significant differences in the clinical outcomes of patients with celiac disease and Crohn’s disease may argue against an effect of the shared risk loci between CD and celiac disease in influencing the natural history of disease. It may also be indicative that the association between immunological response seen against luminal microbial antigens and severe disease may not extend to dietary antigens such as gliadin.…”

Section: Discussionmentioning

confidence: 99%

Impact of Coexistent Celiac Disease on Phenotype and Natural History of Inflammatory Bowel Diseases

Oxford

Nguyen

Sauk

et al. 2013

American Journal of Gastroenterology

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Introduction Inflammatory bowel disease (IBD) and celiac disease are the two most common immune-mediated gastrointestinal diseases. There is limited knowledge regarding the course of IBD in those with co-existing celiac disease. We conducted this study to determine whether patients with co-existing celiac disease present a unique phenotype of IBD and to examine the frequency of co-occurrence of celiac disease and IBD in comparison to other autoimmune disorders. Methods This was a case-control study performed at two tertiary referral centers. Cases comprised of patients with known diagnoses of celiac disease and IBD. Two random IBD controls without celiac disease were selected for each case after matching for IBD type. Disease phenotype and natural history for both CD and UC were noted from medical record review, and were compared between IBD patients with and without celiac disease. Results We identified a total of 51 patients with IBD [22 ulcerative colitis (UC), 1 indeterminate colitis, 28 Crohn’s disease (CD)] and celiac disease. There was no significant difference in the age, gender, or ethnicity between celiac-IBD and controls. Pancolitis was more common in celiac-UC patients as compared to controls (odds ratio 3.30, 95% confidence interval 1.05–21.50). There was also a trend towards increased use of immunomodulators among celiac-UC patients than in non-celiac UC controls (OR 2.83, CI 95% 0.95 – 8.48). No phenotypic differences were found in celiac-CD patients. There were no significant differences in IBD-related medication usage, hospitalizations, or surgeries. Conclusion Patients with UC and celiac disease were more likely to have pancolitis and had a trend towards greater use of immunomodulators. Co-existing celiac disease did not influence natural history of CD.

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Section: Discussionmentioning

confidence: 99%

Impact of Coexistent Celiac Disease on Phenotype and Natural History of Inflammatory Bowel Diseases

Oxford

Nguyen

Sauk

et al. 2013

American Journal of Gastroenterology

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“…Virtually all celiac disease patients share certain HLA-DQ molecules (HLA-DQ2 or HLA-DQ8), while dietary responses lead to specific antigenic peptides in the diet that are present in wheat, rye, and barley [96]. Tursi et al [99] provided data to show a high prevalence of celiac disease among patients affected by CD, and indeed suggested that all CD patients should be started immediately on a glutenfree diet at diagnosis.…”

Section: Mhcii and Hlamentioning

confidence: 97%

Nutrigenomics in the whole-genome scanning era: Crohn’s disease as example

Ferguson

Philpott

Dryland

2007

Cell. Mol. Life Sci.

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Nutrigenomics has the potential to tailor diets to optimize health, based on knowledge of key genetic polymorphisms. Identification of candidate genes is often based on a priori knowledge of disease processes. However, genome-wide association methods are not only validating previously identified genes and polymorphisms, but also revealing new gene-disease associations not anticipated from prior knowledge. In Crohn's disease (CD), such studies not only confirm the importance of caspase-activated recruitment domain 15 and major histocompatibility complex II molecules, but also reveal strong associations with the proinflammatory cytokine interleukin-23 receptor and autophagy-related 16-like gene. Genes identified to date in CD can be linked into two interrelated pathways: receptor-mediated cytokine induction or autophagocytosis. New genomic technologies need to be matched with innovative methodologies to characterize the likely impact of foods and to take the field to another dimension of value for human diet development and optimized health.

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“…The association of CD and CeD may be explained by shared genetic predisposition, increased gut permeability to antigens observed in both diseases [7,9,10,14,15,20].…”

Section: Discussionmentioning

confidence: 99%

“…Concomitant occurrence of CeD and CD is rare and has been reported in several case reports and series [9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

The Association of Crohn’s Disease, Celiac Disease and Selective Ig A Deficiency

Tankova¹,

Gerova²,

Getsov³

et al. 2016

IJCD

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Concomitant occurrence of celiac disease (CeD) and Crohn's disease (CD) is rare and has been reported in several case reports and series. We report a case of a 63-year-old man with proximal CD, CeD and selective immunoglobulin (Ig) A deficiency (SIgAD). The patient was admitted in our Clinic for evaluation of epigastric pain, nausea, vomiting and weight loss (up to 7 kg) appeared in the last 3 months. The imaging findings from abdominal ultrasound and CT enterography raised suspicion of a lymphoproliferative disease of the jejunum. To exclude the development of lymphoma based on long standing untreated atypical CeD, upper endoscopy with biopsies and serological tests were conducted, showing and subtotal villous atrophy and elevated levels of IgG tissue transglutaminase tTG. Histopathology documented CD (A3,L4,B2 according to Montreal's classification).

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Association of Crohn’s disease and latent celiac disease: a case report and review of the literature

Cited by 26 publications

References 24 publications

Impact of Coexistent Celiac Disease on Phenotype and Natural History of Inflammatory Bowel Diseases

Impact of Coexistent Celiac Disease on Phenotype and Natural History of Inflammatory Bowel Diseases

Nutrigenomics in the whole-genome scanning era: Crohn’s disease as example

The Association of Crohn’s Disease, Celiac Disease and Selective Ig A Deficiency

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