2017
DOI: 10.1590/0037-8682-0015-2017
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Abstract: Introduction: Trypanosoma cruzi (Tc) infection is usually acquired in childhood in endemic areas, leading to Chagas disease, which progresses to Chagas cardiomyopathy in 20-30% of infected individuals over decades. The pathogenesis of Chagas cardiomyopathy involves the host inflammatory response to T. cruzi, in which upstream caspase-1 activation prompts the cascade of inflammatory chemokines/cytokines, cardiac remodeling, and myocardial dysfunction. The aim of the present study was to examine the association … Show more

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Cited by 6 publications
(24 citation statements)
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References 36 publications
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“…In contrast with this data, Blankenberg et al reported that in Caucasian patients with CAD, the A allele of the rs501192 A / G polymorphism exhibited a borderline association with a decreased risk of developing CAD ( p = 0.053) [ 22 ]. Alternatively, prior studies have shown (with positive and negative results in different populations) that the rs580253 A / G and rs501192 A / G polymorphisms have an important role in the development of diseases such as ACS, Chagas cardiomyopathy, Alzheimer’s, and cancer [ 15 , 23 , 24 , 25 ]. On the other hand, our results showed an increased frequency of the haplotypes ( AG and GA ) conformed by rs580253 A / G and rs501192 A / G polymorphisms in patients with restenosis.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast with this data, Blankenberg et al reported that in Caucasian patients with CAD, the A allele of the rs501192 A / G polymorphism exhibited a borderline association with a decreased risk of developing CAD ( p = 0.053) [ 22 ]. Alternatively, prior studies have shown (with positive and negative results in different populations) that the rs580253 A / G and rs501192 A / G polymorphisms have an important role in the development of diseases such as ACS, Chagas cardiomyopathy, Alzheimer’s, and cancer [ 15 , 23 , 24 , 25 ]. On the other hand, our results showed an increased frequency of the haplotypes ( AG and GA ) conformed by rs580253 A / G and rs501192 A / G polymorphisms in patients with restenosis.…”
Section: Discussionmentioning
confidence: 99%
“…In a mouse model, overexpression of LPAR2 induces intestinal dysplasia, which therefore alters the proliferation and differentiation of the intestinal epithelial cells (IEC) [ 78 ]. The pivotal inflammasome component, Caspase-1 , is an emerging player in various diseases progressions, as well as a biomarker for early diagnosis and a therapeutic target [ 79 , 80 , 81 , 82 ]. The encoded protein of the NHS gene regulates the development of brain, craniofacial, eye, and tooth, in addition to actin remodeling and thus maintaining cell morphology.…”
Section: Discussionmentioning
confidence: 99%
“…Studies have reported that ethanol-induced apoptosis serves a key role in the pathogenesis of ACM (2629). A study on the mechanism of ethanol-induced cardiomyocyte apoptosis demonstrated that the levels of tumor necrosis factor-α, the apoptotic protein Bcl-2-associated X and caspase-3 are significantly increased in ACM (30). In the present study, AC16 cardiomyocytes were treated with ethanol and its effects on apoptosis analyzed.…”
Section: Discussionmentioning
confidence: 99%