Association of C-reactive protein and serum amyloid A with recurrent coronary events in stable patients after healing of acute myocardial infarction

Harb, Tareq S.; Zaręba, Wojciech; Moss, Arthur J.; Ridker, Paul M.; Marder, Victor J.; Rifai, Nader; Watelet, Luc F. Miller; Arora, Rohit; Brown, Mary W.; Case, Robert B.; Dwyer, Edward M.; Gillespie, John A.; Goldstein, Robert E.; Greenberg, Henry; Hochman, Judith S.; Krone, Ronald J.; Liang, Chang‐seng; Lichstein, Edgar; Little, William C.; Marcus, Frank I.; Oakes, David; Sparks, Charles E.; VanVoorhees, Lucy

doi:10.1016/s0002-9149(01)02204-4

Cited by 51 publications

(32 citation statements)

References 18 publications

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“…This lack of association could be explained in light of a different regulation of SAA and CRP production by cytokines and of a greater variability in SAA levels compared with CRP. Moreover, measurement of SAA in stable post-infarction patients in the THROMBO Study shows no significant association between SAA and risk of recurrent cardiovascular events over 2 years [24]: in this study, however, neither SAA or CRP are found to be independent markers of recurrent instability.…”

Section: Serum Amyloid a (Saa)contrasting

confidence: 81%

Inflammatory biomarkers and coronary heart disease: from bench to bedside and back

et al. 2010

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Inflammation plays a pivotal role in all stages of atherosclerosis from endothelial dysfunction and plaque formation to plaque destabilization and disruption. Inflammatory biomarkers, originally studied to better understand the pathophysiology of atherosclerosis, have generated increasing interest among clinicians, because of their utility in the challenging problems of diagnosis and risk assessment of patients with suspected or proved coronary heart disease. Moreover, in fascinating perspective, they could be used as therapeutic target, counteracting initiation, progression, and development of complications of atherosclerosis. In this review, we will provide an overview of the more promising inflammatory biomarkers, focusing on their utility and limitations in the clinical setting.

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Section: Serum Amyloid a (Saa)contrasting

confidence: 81%

Inflammatory biomarkers and coronary heart disease: from bench to bedside and back

et al. 2010

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“…Much evidence exists for the detrimental impact of proinflammatory cytokines (24,25 ). Recent data consistently suggest that antiinflammatory markers may have similar importance and may be even more important than proinflammatory mediators (7,8 ).…”

Section: Discussionmentioning

confidence: 99%

Fetuin-A Is an Independent Predictor of Death after ST-Elevation Myocardial Infarction

et al. 2007

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Background: Fetuin-A inhibits inflammation and has a protective effect against myocardial ischemia. Its deficiency has been found to be associated with cardiovascular death in patients with end-stage renal failure disease. We investigated the association between plasma fetuin-A and clinical outcome after ST-elevation acute myocardial infarction (STEMI). Methods: We measured fetuin-A in 284 consecutive patients with STEMI and correlated these data with the occurrence of death at 6 months (n ‫؍‬ 25). We also measured fetuin-A in a control group and chose the 95th percentile as the cutoff to define abnormality.

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“…9 In contrast, measurement of SAA 2 months after MI in the Thrombogenic Factors and Recurrent Coronary Events (THROMBO) Study showed no significant association between SAA and risk of recurrent cardiovascular events over 2 years. 21 …”

Section: Serum Amyloid Amentioning

confidence: 99%

Inflammatory Biomarkers in Acute Coronary Syndromes

2006

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Association of C-reactive protein and serum amyloid A with recurrent coronary events in stable patients after healing of acute myocardial infarction

Cited by 51 publications

References 18 publications

Inflammatory biomarkers and coronary heart disease: from bench to bedside and back

Inflammatory biomarkers and coronary heart disease: from bench to bedside and back

Fetuin-A Is an Independent Predictor of Death after ST-Elevation Myocardial Infarction

Inflammatory Biomarkers in Acute Coronary Syndromes

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