Association of Bone Metabolism with Fatty Liver Disease in the Elderly in Japan: A Community-based Study

Abstract

Objective With the aging of society, both osteoporosis and fatty liver disease (FLD) are becoming important issues. However, the relationship between osteoporosis and FLD remains controversial. We investigated the association between bone metabolism and FLD in a Japanese community in a cross-sectional study. Methods A total of 1,020 participants were enrolled in a health survey. FLD was diagnosed by ultrasonography. Bone metabolism was evaluated based on bone mineral density (BMD), which was assessed using dual-energy X-ray absorptiometry, and with the bone formation index (total type I procollagen N-terminal propeptide/bone-alkaline phosphatase ratio; P1NP/BAP ratio) and the bone resorption index (crosslinked Ntelopeptide of type I collagen/tartrate-resistant acid phosphatase-5b ratio; NTx/TRACP-5b ratio) calculated from serum bone turnover markers. Results The BMD (percentage of the young adult mean) was the same level in both male and female participants with and without FLD. Both men and women showed an age-dependent decrease in their bone formation index and bone resorption index values. Men of ! 70 years of age and women of 60-69 years of age with FLD had significantly lower bone formation index values and higher bone resorption index values. However, similar findings were not seen in women of ! 70 years of age. Conclusion Although the BMD levels were the same, regardless of the presence or absence of FLD, elderly participants with FLD showed decreased bone formation and increased bone resorption, with sex differences. Because our results suggest that FLD in elderly individuals is detrimental for bone metabolism, and that it leads to bone loss and osteoporosis, further studies using a cohort population are warranted.

Association of serum creatinine-to-cystatin C ratio with skeletal muscle mass and strength in nonalcoholic fatty liver disease in the Iwaki Health Promotion Project

“…This program has been conducted annually since 2005 with approximately 1,000 participants in the Iwaki region of Hirosaki City in Aomori Prefecture in northern Japan. (16)(17)(18)(19) All the study subjects participated voluntarily in response to a public announcement, and approximately 600 data points were collected from each participant, including their demographics, medical history, lifestyle data, and microbiota and blood chemical analysis data. To date, we have shown the association of NAFLD with adipokines, microbiota, and changed amino acids in this health promotion study.…”

Non-Alcoholic Fatty Liver Disease and Bone Tissue Metabolism: Current Findings and Future Perspectives

“…In turn, such pathological processes (myosteatosis, sarcopenia, and disorders of bone tissue metabolism) may be associated with an aggravated course of NAFLD. Some studies established that bone turnover in elderly patients with NAFLD was associated with a slowdown in the rate of bone formation and increased rate of bone resorption, which was indicative of an amplified risk of developing osteoporosis in this cohort [10][11][12].…”

The National Consensus statement on the management of adult patients with non-alcoholic fatty liver disease and main comorbidities

“…В китайской популяции была обнаружена отрицательная связь между НАЖБП и МПК как у женщин в постменопаузе, так и у мужчин. Подобные результаты были обнаружены в популяции корейских мужчин [210]. Также было продемонстрировано, что НАЖБП может оказывать негативное влияние на МПК у подростков с ожирением, вероятно, за счет ИР.…”