Association of Body Mass Index With Cardiac Reverse Remodeling and Long-Term Outcome in Advanced Heart Failure Patients With Cardiac Resynchronization Therapy

Cai, Chi; Hua, Wei; Ding, Li-Gang; Wang, Jing; Chen, Keping; Yang, Xinwei; Liu, Zhimin; Zhang, Shu

doi:10.1253/circj.cj-14-0812

Cited by 21 publications

(22 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…24-26 Finally, we obtained data only at mid-term follow-up (3 months), and therefore future studies should assess whether the results are maintained over a longer follow-up time. 27 In conclusion, our data showed that utilization of a quadripolar lead was associated with a better functional outcome compared with a standard bipolar lead; if confirmed in large …”

Section: Study Limitationssupporting

confidence: 63%

Outcome of Patients Treated by Cardiac Resynchronization Therapy Using a Quadripolar Left Ventricular Lead

Bencardino

Monaco

Russo

et al. 2016

Circ J

View full text Add to dashboard Cite

Background: Not all heart failure (HF) patients benefit from cardiac resynchronization therapy (CRT). We assessed whether choosing the site of left ventricular (LV) pacing by a quadripolar lead may improve response to CRT. Methods and Results:We prospectively randomized 23 patients with HF (67±11 years; 21 males) to CRT with a quadripolar LV lead (group 1, with the LV pacing site chosen on the basis of QRS shortening using simultaneous biventricular pacing), and 20 patients (71±6 years; 16 males) to a bipolar LV lead (group 2, with devices programmed with a conventional tip-to-ring configuration). New York Heart Association (NYHA) class and LV ejection fraction (EF) by 2D echocardiography were assessed at baseline and after 3 months. The baseline EF was not different between the 2 groups (25±6% group 1 vs. 27±3% group 2; P=0.22), but after 3 months EF was higher in group 1 (35±13% group 1 vs. 31±4% group 2; P<0.001). A reduction in at least 1 NYHA class at 3 months was observed in 22 (96%) and 12 (60%) of group 1 and group 2 patients, respectively (P<0.05). Conclusions:CRT with a quadripolar LV lead was associated with an improvement of EF greater than that observed in patients receiving a bipolar LV lead. In devices with a quadripolar lead, CRT programming based on the best QRS shortening is reliable and effective. (Circ J 2016; 80: 613 -618)

show abstract

Section: Study Limitationssupporting

confidence: 63%

Outcome of Patients Treated by Cardiac Resynchronization Therapy Using a Quadripolar Left Ventricular Lead

Bencardino

Monaco

Russo

et al. 2016

Circ J

View full text Add to dashboard Cite

show abstract

“…A recent study showed that underweight patients had worse prognosis for advanced heart failure than overweight patients. 30 In the present study, there was a tendency for poor prognosis in patients with lower BMI, but BMI did not remain a candidate for multivariate analysis. Reduced eGFR and anemia are well-known to be associated with increased mortality in heart failure.…”

Section: Yamabe S Et Alcontrasting

confidence: 53%

Prognostic Factors for Survival in Pulmonary Hypertension Due to Left Heart Disease

Yamabe

Dohi

Fujisaki

et al. 2016

Circ J

View full text Add to dashboard Cite

“…10 Similarly, in the setting of NYHA class III-IV HF, obese and overweight patients, when compared to normal-weight and underweight patients, benefited from greater improvements in left ventricular (LV) end-diastolic diameter and LV ejection fraction after implantation of CRT. 11 In this cohort, obesity and overweight status were further related to greater CRT response rates (obese: 82.9%, overweight: 77.1%, normal: 52.2%, underweight: 33.3%), as well as a lower risk of mortality and combined end point of death and HF hospitalizations.…”

Section: The Goodmentioning

confidence: 71%

“…This relationship between obesity and CRT outcomes may further be related to the severity of the underlying cardiomyopathy, whereby excess weight in advanced HF but not mild HF patients appears to improve outcomes. [9][10][11][12][13][14] Why do advanced HF patients implanted with CRT do better when obese? It is conceivable that excess body fat signifies metabolic reserves in HF patients, making them less vulnerable to the catabolic state and allowing greater benefit from CRT than in leaner patients.…”

Section: The Goodmentioning

confidence: 99%

“…In one study, obese and overweight patients presented with lower baseline risk for non-response to CRT, experienced shorter duration between HF symptom onset and CRT implantation, and exhibited better tolerance of aggressive HF medical therapy, all observations that were described as potential reasons for greater CRT benefit. 11 Further research is thus needed to clarify mechanisms involved in mediating the effects of obesity on CRT response.…”

Section: The Goodmentioning

confidence: 99%

See 1 more Smart Citation

Obesity, Weight Loss, Cachexia and Cardiac Resynchronization Therapy: the Good, the Bad, and the Ugly

Daimee¹,

Aktaş²,

Kutyifa³

2016

JICRM

View full text Add to dashboard Cite

ABSTRACT. Obesity has long been known for its deleterious consequences on cardiovascular outcomes. Recent studies have suggested that extra pounds are beneficial for heart failure (HF) patients, while weight loss and cachexia may be markers of poor clinical outcomes in the setting of chronic HF. Nevertheless, the implications of obesity, weight reduction, and cachexia in patients receiving cardiac resynchronization therapy (CRT) is less known. In this short communication, we review current literature on the effects of obesity, weight loss, and cardiac cachexia (the Good, the Bad, and the Ugly) on outcomes in HF patients, with a focus on those receiving CRT. We further offer our perspectives on the clinical applications of current research.

show abstract

Association of Body Mass Index With Cardiac Reverse Remodeling and Long-Term Outcome in Advanced Heart Failure Patients With Cardiac Resynchronization Therapy

Cited by 21 publications

References 23 publications

Outcome of Patients Treated by Cardiac Resynchronization Therapy Using a Quadripolar Left Ventricular Lead

Outcome of Patients Treated by Cardiac Resynchronization Therapy Using a Quadripolar Left Ventricular Lead

Prognostic Factors for Survival in Pulmonary Hypertension Due to Left Heart Disease

Obesity, Weight Loss, Cachexia and Cardiac Resynchronization Therapy: the Good, the Bad, and the Ugly

Contact Info

Product

Resources

About