Association of birth outcomes and postnatal growth with adult leukocyte telomere length: Data from New Delhi Birth Cohort

Tarik, Mohamad; Ramakrishnan, Lakshmy; Sinha, Sikha; Sachdev, H P S; Tandon, Nikhil; Roy, Ambuj; Bhargava, Santosh K.

doi:10.1111/mcn.12857

Cited by 6 publications

(3 citation statements)

References 45 publications

(66 reference statements)

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“…Child bTL values identified as outliers (± 3 SD from the Mean) were winsorized. Child bTL values were then z-transformed for analyses to improve comparability across studies, as has been recommended (Verhulst, 2020) Preliminary analyses examined sample characterstics and bivariate correlations of child buccal telomere length with child demographic (child age, sex, race as African-American vs. other; ethnicity as Hispanic vs. other), mother demographic (years education, per capita income adjusted for cost of living in the site), father age, mother health (prepregnancy BMI, smoking during pregnancy, gestational diabetes) and pregnancy outcome variables (child birth weight, gestational length) to identify potential covariates given previous links to these factors and child telomere length (Liu et al, 2019;Needham et al, 2012;Tarik et al, 2019;Factor-Litvak et al, 2016;Xu et al, 2014;Ip et al, 2017;Akkad et al, 2006;Martens et al, 2016). Any variable significantly associated with child telomere length was included as a covariate in follow-up analyses.…”

Section: Statistical Analysesmentioning

confidence: 99%

Prenatal maternal stress prospectively relates to shorter child buccal cell telomere length

Carroll

Mahrer

Shalowitz

et al. 2020

Psychoneuroendocrinology

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Prenatal exposure to stress increases risk for suboptimal child and adult mental and physical health outcomes, hypothesized to occur via fetal exposure to maternal stress hormones that alter growth and development. One proposed pathway through which stress exposure in utero could affect the offspring is by accelerating cellular aging in the form of telomere attrition. We tested this hypothesis in a cohort of 111 mother-child dyads, where mothers were assessed over 6 or more years, beginning prior to conception, and later during pregnancy, postpartum, and when the children were 3-5 years old. Adjusting for child age and concurrent maternal stress, we found that higher maternal perceived stress in the 3rd trimesters of pregnancy was predictive of shorter child buccal telomere length (bTL) (β = − 0.24, p < .05), while maternal preconception and postpartum maternal stress were not associated with bTL (all p's > 0.42). These findings suggest a vulnerable time period in pregnancy when maternal stress influences offspring telomere length, suggesting the early embedding of adult disease might occur through biological aging pathways.

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Section: Statistical Analysesmentioning

confidence: 99%

Prenatal maternal stress prospectively relates to shorter child buccal cell telomere length

Carroll

Mahrer

Shalowitz

et al. 2020

Psychoneuroendocrinology

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show abstract

“…In men, lower birth weight predicted advanced biological aging based on epigenetic clocks [94]. Furthermore, no association was found between birth weight and telomere length in humans [95][96][97]. Masterson et al [98] showed that heavier birth weight was associated with longer telomere length but the relationship was attenuated by maternal age at birth and probably rather related to childhood growth.…”

Section: Discussionmentioning

confidence: 99%

Birth size and the pace of aging in men

Żelaźniewicz,

Nowak-Kornicka,

Pawłowski

2023

Preprint

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Previous studies showed that intrauterine growth restrictions, resulting in smaller body size at birth, are associated with altered development and the risk of age-related diseases in adult life. Thus, prenatal development may predict aging trajectories in humans. The study aimed to verify if body size at birth is related to biological age in adult men. The study sample consisted of 159 healthy, non-smoking men with a mean age of 35.24 (SD = 3.44) years. Birth weight and length were taken from medical records. The ponderal index at birth was calculated. Biological age was evaluated based on serum levels of s-Klotho, hsCRP, DHEA/S, and oxidative stress markers. Pregnancy age at birth, lifestyle, weight, cortisol, and testosterone levels were controlled. The results showed no relationship between birth size and s-Klotho, DHEA/S level, inflammation, or oxidative stress. Also, men born as small-for-gestational-age (N = 49) and men born as appropriate-for-gestational-age (N = 110) did not differ in terms of biological age markers levels. The results were similar when controlled for pregnancy week at birth, chronological age, BMI, testosterone, or cortisol level. The results suggest that there is no relationship between intrauterine growth and biomarkers of aging in men aged 30–45 years from the affluent population.

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“…3 Since the explication of the Barker hypothesis, numerous investigations have been used to attempt to find its molecular basis. Explanations include reductions in telomere length 4 and changes in the epigenetic profile, 5 both hypothesized to result in increased rates of cellular aging. 6 Specific patterns in DNA methylation thought to be age related define the construct of epigenetic clocks, which are used to estimate aging and age-related disease risk.…”

mentioning

confidence: 99%

Is There a Molecular Basis to Accelerated Aging?

Factor-Litvak

2021

Pediatrics

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Association of birth outcomes and postnatal growth with adult leukocyte telomere length: Data from New Delhi Birth Cohort

Cited by 6 publications

References 45 publications

Prenatal maternal stress prospectively relates to shorter child buccal cell telomere length

Prenatal maternal stress prospectively relates to shorter child buccal cell telomere length

Birth size and the pace of aging in men

Is There a Molecular Basis to Accelerated Aging?

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