Association of APOA5 rs662799 and rs3135506 polymorphisms with arterial hypertension in Moroccan patients

Ouatou, Sanaa; Ajjemami, Maria; Charoute, Hicham; Sefri, Hajar; Ghalim, Noreddine; Rhaissi, Houria; Benrahma, Houda; Barakat, Abdelhamid; Rafiey, Hassan

doi:10.1186/1476-511x-13-60

Cited by 27 publications

(23 citation statements)

References 45 publications

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“…In our study TC and CC genotype of APOA5-1131T/C were more common in AMI patients with previous diagnosed hypertension than in patients without hypertension and had significant association with AMI patients. This result disagrees with the observation reported by Ouatou et al where data demonstrated that 56C>G SNP has a significant influence on blood pressure and triglyceride level (Ouatou et al, 2014). Although the association between diabetes and cardiovascular disease is unquestioned, the underlying mechanisms of the macrovascular complications are not well defined (Lardizabal et al, 2010).…”

Section: Discussioncontrasting

confidence: 61%

Influence of APOA5 (rs662799 and rs3135506) gene polymorphism in acute myocardial infarction patients and its association with basic coronary artery disease risk factors

Srivastava¹,

Singh²,

Verma³

et al. 2015

J App Pharm Sci

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The aim of this study was to examine the allele and genotype of APOA5 -1131T/C (rs662799) and APOA5-56C/G (rs3135506) gene in acute myocardial (AMI) case and control subjects. 304 case and 304 controls were enrolled in this study. DNA was extracted using salting out method followed by polymerase chain reaction amplification and restriction endonuclease digestion (using MseI for -1131T/C and Taq1 for -56C/G). Digested PCR products were identified using agarose gel electrophoresis and stained with ethidium bromide. There was a strong association between APOA5 -1131T/C (TC vs. TT, OR= 1.58 and CC vs. TT OR= 2.43) and APOA5 -56C/G (CG vs. CC, OR= 1.64 and GG vs. CC, OR= 2.44) polymorphisms with AMI. Out of the six potential risk factors for coronary artery disease, only smoking, diabetes and hypertension were found to be associated with APOA5 gene and increased the risk of AMI. Smoking was the most prominent risk factor for both the genes. Other risk factors like history of dyslipidemia, obesity and family history of coronary artery disease did not reveal any potential association with the candidate gene. Our data demonstrate that both the SNPs in the APOA5 gene (-1131T/C, and -56C/G) were strongly associated with AMI in north Indian population.

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Section: Discussioncontrasting

confidence: 61%

Influence of APOA5 (rs662799 and rs3135506) gene polymorphism in acute myocardial infarction patients and its association with basic coronary artery disease risk factors

Srivastava¹,

Singh²,

Verma³

et al. 2015

J App Pharm Sci

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“…( Supplementary Table S12), involved in regulation of intestinal cholesterol absorption. Variants in some of these genes have been associated to high levels of LDL and total cholesterol (Bandarian et al 2013;the ENGAGE Consortium et al 2009) (Bandarian et al, 2013;the ENGAGE Consortium et al, 2009) (Bandarian et al 2013;the ENGAGE Consortium et al 2009) (Bandarian et al 2013;the ENGAGE Consortium et al 2009) as well as high triglyceride levels (Pennacchio et al 2002;Zhu et al 2014;Ouatou et al 2014), both factors leading to cardiovascular disease. The derived allele of rs3135506 in APOA-5 has the highest frequency in HUI compared to the other populations from the study and the TGP1000 ( Supplementary Table S12).…”

Section: Targets Of Adaptive Evolution In Nmmentioning

confidence: 99%

“…The derived allele of rs3135506 in APOA-5 has the highest frequency in HUI compared to the other populations from the study and the TGP1000 ( Supplementary Table S12). This missense mutation (S19W) has been associated with increased triglyceride levels and elevated risk of developing coronary artery disease in several populations including one labeled as "Hispanic" (Pennacchio et al 2002;Zhu et al 2014;Ouatou et al 2014). Moreover, HUI has the highest frequency of the missense mutation rs6756629 in ABCG5, which has been associated to increased total cholesterol and LDL (the ENGAGE Consortium et al 2009), a risk factor for coronary heart disease.…”

Section: Targets Of Adaptive Evolution In Nmmentioning

confidence: 99%

Population history and gene divergence in Native Mexicans inferred from 76 human exomes

Ávila‐Arcos

McManus

Sandoval

et al. 2019

Preprint

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Native American genetic variation remains underrepresented in most catalogs of human genome sequencing data. Previous genotyping efforts have revealed that Mexico's indigenous population is highly differentiated and substructured, thus potentially harboring higher proportions of private genetic variants of functional and biomedical relevance. Here we have targeted the coding fraction of the genome and characterized its full site frequency spectrum by sequencing 76 exomes from five indigenous populations across Mexico. Using diffusion approximations, we modeled the demographic history of indigenous populations from Mexico with northern and southern ethnic groups splitting 7.2 kya and subsequently diverging locally 6.5 kya and 5.7 kya, respectively. Selection scans for positive selection revealed BCL2L13 and KBTBD8 genes as potential candidates for adaptive evolution in Rarámuris and Triquis, respectively. BCL2L13 is highly expressed in skeletal muscle and could be related to physical endurance, a well-known phenotype of the northern Mexico Rarámuri. The KBTBD8 gene has been associated with idiopathic short stature and we found it to be highly differentiated in Triqui, a southern indigenous group from Oaxaca whose height is extremely low compared to other native populations.

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“…Literature report that about 50% of their final levels are genetically determined (Hubáček et al, 2009). Numerous studies have reported a significant association between the T1131C APOA5 variant and cardiovascular diseases development, especially myocardial infarction (MI) (Hubáček et al, 2003(Hubáček et al, , 2009Hubacek et al, 2004;Szalai et al, 2004;Zhou et al, 2013;Ouatou et al, 2014). However, this association was not observed in many other studies (Prochaska et al, 2010;Martinelli et al, 2007;Lee et al, 2004).…”

Section: Apoa5mentioning

confidence: 99%

Association of G894T eNOS, 4G/5G PAI and T1131C APOA5 polymorphisms with susceptibility to myocardial infarction in Morocco

Idrissi¹,

Hmimech²,

Diakité³

et al. 2017

Archives of Cardiovascular Diseases Supplements

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Background: Myocardial infarction (MI) is a common multifactorial disease. Numerous studies have found that genetic plays an essential role in MI occurrence. The main objective of our case-control study is to explore the association of G894T eNOS (rs1799983), 4G/5G PAI (rs1799889) and T1131C APOA5 (rs662799) polymorphisms with MI susceptibility in the Moroccan population. Methods and results: 118 MI patients were recruited vs 184 healthy controls. DNA samples were genotyped by PCR-RFLP method using MboI, BslI and MseI restriction enzymes respectively for the G894T eNOS, 4G/5G PAI and T1131C APOA5 polymorphisms. Our results show that the G894T eNOS was significantly associated with increased risk of MI under the three genetic transmission models (dominant: OR = 1.64, 95% CI = 1.05-2.58, P = 0.003; recessive: OR = 2.15, 95% CI = 0.74-6.16, P = 0.03; additive: OR = 1.54, 95% CI = 1.06-2.23, P = 0.001). The T1131C APOA5 polymorphism was associated to MI risk in recessive and additive models (OR = 1.53, 95% CI = 0.72-3.2, P = 0.04 and OR = 1.78, 95% CI = 1.26-2.51, P = 0.03 respectively). For the 4G/5G PAI variant, even the cases and controls groups were not in Hardy-Weinberg Equilibrium (HWE), the dominant and additive models show a statistically significant association with MI risk (OR = 7.96,, P = 0.01 and OR = 1.96, 95% CI = 1.4-2.72, P = 0.03 respectively). Conclusion: Our results suggest that G894T eNOS and T1131C APOA5 polymorphisms may be considered as genetic markers of MI among the Moroccan population. Further studies including larger sample sizes and exploring more genetic associations are needed to confirm our results and to better understand the susceptibility to MI.

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Association of APOA5 rs662799 and rs3135506 polymorphisms with arterial hypertension in Moroccan patients

Cited by 27 publications

References 45 publications

Influence of APOA5 (rs662799 and rs3135506) gene polymorphism in acute myocardial infarction patients and its association with basic coronary artery disease risk factors

Influence of APOA5 (rs662799 and rs3135506) gene polymorphism in acute myocardial infarction patients and its association with basic coronary artery disease risk factors

Population history and gene divergence in Native Mexicans inferred from 76 human exomes

Association of G894T eNOS, 4G/5G PAI and T1131C APOA5 polymorphisms with susceptibility to myocardial infarction in Morocco

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