Association of Apelin and Apelin Receptor Polymorphisms With the Risk of Comorbid Depression and Anxiety in Coronary Heart Disease Patients

Abstract

The Apelin (APLN)/apelin receptor (APLNR) signaling pathway is a newly identified regulator in various cardiovascular diseases, which is considered as a candidate pathway for the occurrence of coronary heart disease (CHD), depression, and anxiety. The goal of this study was to investigate the association between APLN/APLNR gene polymorphisms and the risk of depression and anxiety in CHD patients. To this end, a case-control study involving 269 CHD patients and 184 healthy control individuals was conducted. The 269 patients with CHD including 122 patients with and 147 patients without depression, and 56 patients with and 213 patients without anxiety Four single nucleotide polymorphisms were selected and successfully genotyped using Sanger sequencing. The APLN rs2235310T allele and APLNR rs9943582C allele were found to be associated with an increased risk of CHD after multiple test correction (Padjust < 0.05). The patients with CHD who carried the rs9943582C allele had a higher risk of depression, after adjusting for alcohol drinking habits, insomnia, hypertension, and stroke history, with the Bonferroni correction (P-adjust = 0.018). The APLNR rs2282623 T allele was associated with an increased risk of anxiety in CHD patients after adjusting for related disease complications, with the Bonferroni correction (Padjust = 0.022). We reported for the first time that the APLN rs2235310 and APLNR rs2282623 polymorphisms are associated with the risks of psychiatric disorders in CHD patients and may serve as novel biomarkers for therapy.

Bioinformatics Screening and Experimental Validation for Deciphering the Immune Signature of Late-Onset Depression

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Bioinformatics Screening and Experimental Validation for Deciphering the Immune Signature of Late-Onset Depression

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Elucidating cardiomyocyte heterogeneity and maturation dynamics through integrated single-cell and spatial transcriptomics

“…Pathways such as Ptn-Ncl and Apln-Aplnr were particularly notable, exemplifying the complex signaling interactions necessary for coordinated heart function. 24 , 25 The intercellular communication in the atrial compartments, facilitated by pathways such as the Igf2-Igf2r axis, highlights the complexity of cardiac signaling networks ( Figures 7 A–7C). The importance of the Igf2-Igf2r axis in vascular development is further supported by studies highlighting its critical function in placental microvasculature expansion and the recruitment of endothelial progenitor cells.…”

Potential mechanisms of traditional Chinese medicine in treating insomnia: A network pharmacology, GEO validation, and molecular-docking study

“…Meanwhile, the downstream pathway of hsa-miR-130a contained apelin signaling pathway, which was associated with cardiovascular disorders, and had been suggested to be a candidate pathway for the development of coronary heart disease, depression, and anxiety disorders. [ 82 ] In the results of molecular docks, β-sitosterol, stigmasterol, cryptotanshinone, and cavidine all showed good docking affinity (affinity < –7 kcal/mol) with TP53. The β-sitosterol and stigmasterol also showed good affinity with FOS.…”

Bioinformatics Screening and Experimental Validation for Deciphering the Immune Signature of Late-Onset Depression

“……”

“……”

Elucidating cardiomyocyte heterogeneity and maturation dynamics through integrated single-cell and spatial transcriptomics

“…Pathways such as Ptn-Ncl and Apln-Aplnr were particularly notable, exemplifying the complex signaling interactions necessary for coordinated heart function. 24 , 25 The intercellular communication in the atrial compartments, facilitated by pathways such as the Igf2-Igf2r axis, highlights the complexity of cardiac signaling networks ( Figures 7 A–7C). The importance of the Igf2-Igf2r axis in vascular development is further supported by studies highlighting its critical function in placental microvasculature expansion and the recruitment of endothelial progenitor cells.…”

Potential mechanisms of traditional Chinese medicine in treating insomnia: A network pharmacology, GEO validation, and molecular-docking study

“…Meanwhile, the downstream pathway of hsa-miR-130a contained apelin signaling pathway, which was associated with cardiovascular disorders, and had been suggested to be a candidate pathway for the development of coronary heart disease, depression, and anxiety disorders. [ 82 ] In the results of molecular docks, β-sitosterol, stigmasterol, cryptotanshinone, and cavidine all showed good docking affinity (affinity < –7 kcal/mol) with TP53. The β-sitosterol and stigmasterol also showed good affinity with FOS.…”

Bioinformatics Screening and Experimental Validation for Deciphering the Immune Signature of Late-Onset Depression

“……”

“……”

Elucidating cardiomyocyte heterogeneity and maturation dynamics through integrated single-cell and spatial transcriptomics

“…Pathways such as Ptn-Ncl and Apln-Aplnr were particularly notable, exemplifying the complex signaling interactions necessary for coordinated heart function. 24 , 25 The intercellular communication in the atrial compartments, facilitated by pathways such as the Igf2-Igf2r axis, highlights the complexity of cardiac signaling networks ( Figures 7 A–7C). The importance of the Igf2-Igf2r axis in vascular development is further supported by studies highlighting its critical function in placental microvasculature expansion and the recruitment of endothelial progenitor cells.…”

Potential mechanisms of traditional Chinese medicine in treating insomnia: A network pharmacology, GEO validation, and molecular-docking study

“…Meanwhile, the downstream pathway of hsa-miR-130a contained apelin signaling pathway, which was associated with cardiovascular disorders, and had been suggested to be a candidate pathway for the development of coronary heart disease, depression, and anxiety disorders. [ 82 ] In the results of molecular docks, β-sitosterol, stigmasterol, cryptotanshinone, and cavidine all showed good docking affinity (affinity < –7 kcal/mol) with TP53. The β-sitosterol and stigmasterol also showed good affinity with FOS.…”