Association of Anti-Ro/Sjögren’s syndrome type A Antibodies and Complete Atrioventricular Block in an Adult With Sjögren’s Syndrome

Tam, Weng Kin; Hsu, Hui Ching; Hsieh, Ming Hsiung; Yeh, Jong Shiuan; Tam, Weng Chio

doi:10.5606/archrheumatol.2018.6492

Cited by 9 publications

(8 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, 19 case reports including 22 patients with SS and MN were also obtained (Table 4). 24‐42 The medium age of these patients was 55 years and 76.2% were female. Sixteen cases had other concurrent diseases, with 3 lymphomas and 13 autoimmune disorders such as rheumatoid arthritis, thyroiditis, Graves’ disease, primary biliary cirrhosis and so on.…”

Section: Resultsmentioning

confidence: 96%

Sjögren’s syndrome complicated with membranous nephropathy, a cause or coincidence?

et al. 2021

View full text Add to dashboard Cite

Background Sjögren's syndrome (SS) has been a well‐documented cause of secondary membranous nephropathy (MN); however, the prevalence is quite low. Since primary MN is also a common disease in middle age, whether MN is secondary to SS or just coincidence remains uncertain. The detection of phospholipase A2 receptor (PLA2R), which is most often positive in idiopathic MN, has been rarely reported in such cases. Methods We retrospectively studied 13 cases diagnosed with MN and SS in Huashan Hospital between 2009 and 2020, and performed PLA2R detection. We also review the literature by searching in the PubMed database. Results Among the 13 patients, 8 were found to be PLA2R‐positive and 5 were negative. Nine patients were female. All but 1 patients had normal renal function at the time of biopsy. All patients showed positive anti‐nuclear antibody and anti‐SSA. Two of the 8 PLA2R‐positive patients showed positive anti‐SSB and 1/8 had mild hypocomplementemia, while all 5 PLA2R‐negative patients had positive anti‐SSB and 3 showed hypocomplementemia. Renal biopsy revealed focal MN and markedly mesangial hyperplasia in PLA2R‐negative patients. Mesangial electron deposits were observed in 1 PLA2R‐positive patient in small amounts, and in 3 PLA2R‐negative patients with 2 in large amounts. During follow‐up, 2 patients in the PLA2R‐negative group presented with progressively decreasing serum complement levels, and another one was diagnosed with systemic lupus erythematosus (SLE). Conclusions In patients with both MN and SS, PLA2R‐negative MN should be considered as a secondary form. Careful screen for SLE is necessary in these patients during follow‐up.

show abstract

Section: Resultsmentioning

confidence: 96%

Sjögren’s syndrome complicated with membranous nephropathy, a cause or coincidence?

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In 1998, a case of complete heart block (CHB) with SS was reported, but this was confounded with hypopituitarism 4. In 2011, an adult female patient had varying degrees of AV block on holter monitor with anti-SSA positivity,5 while in 2018, two further CHB cases with anti-SSA positivity were reported 6 7. We report the fifth case of an adult AV block associated with anti-SSA seropositivity.…”

Section: Discussionmentioning

confidence: 92%

Sjogren syndrome presenting as atrioventricular block in an adult

et al. 2022

View full text Add to dashboard Cite

A woman in her late teens with a history of Juvenile idiopathic arthritis (JIA) and ongoing sicca symptoms presented with syncope. Upon admission, she was found to be bradycardic with a second-degree atrioventricular (AV) block. After infectious, structural and metabolic aetiologies had been ruled out, she was worked up for rheumatologic causes.Our patient had elevated titres of anti-Sjogren syndrome (SS) antibodies anti-Ro antibodies and was diagnosed with AV block secondary to SS. She was treated with a permanent pacemaker. Patient was followed up in clinic where she denied further syncopal episodes and was started on secretagogues for sicca symptoms.

show abstract

“…4,9 CHB is caused by damage to the AV node by anti-SS-A and/or anti-SSB. 15 Congenital heart block generally occurs at 18-24 weeks of gestation, can appear as fetal bradycardia which can be detected by routine fetal auscultation, ultrasound, or pulsed Doppler echocardiography. 16 There is no guideline on the frequency of examinations, some carry out Doppler examinations for 18-26 weeks and every 2 weeks after 32 weeks of age.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive management of pregnant woman with Sjögren’s syndrome

Gunawan

Rahadina

Prasetyo

2022

MOG

View full text Add to dashboard Cite

HIGHLIGHTS 1. Sjögren’s syndrome is a chronic autoimmune disease that attacks the exocrine glands, especially lacrimal and salivary glands. 2. Comprehensive management of pregnant women with Sjögren’s syndrome was described.3. Clinical and laboratory examination, risk assessment and also preconception counseling before planning pregnancy are needed by women with Sjögren’s syndrome. ABSTRACT Objective: To illustrate the comprehensive management of pregnant women with Sjögren syndrome. Case Report: A 24 years old women came to Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, due to Sjögren syndrome in 35/36 weeks of gestasional age for routine examination. She was first diagnosed with Sjögren syndrome in February 2018 because she complained of dry eyes and hair fall out. This was her first pregnancy. Laboratory result showed positive ANA test. The patient had hypertension with controlled blood preasure and dry eyes. The patient was diagnosed with primigravida 35-36 weeks of pregnancy, single live intrauterine, head presentation, IUGR, screening preeclampsia was positive, and there was complication with Sjögren’s syndrome. The patient was treated by multidisciplinary team consisting of obstetricians, internists, ophthalmologists and neonatologists. Conclusion: Sjögren’s syndrome is a chronic autoimmune disease that attacks the exocrine glands, especially lacrimal and salivary glands. The exact cause of Sjögren's syndrome is still not known. Women with Sjögren’s syndrome should have clinical and laboratory examination, risk assessment and also preconception counseling before planning pregnancy because Sjögren syndrome was a rare case during pregnancy. Close monitoring and proper management was imperative to detect the early complication.

show abstract

Association of Anti-Ro/Sjögren’s syndrome type A Antibodies and Complete Atrioventricular Block in an Adult With Sjögren’s Syndrome

Cited by 9 publications

References 18 publications

Sjögren’s syndrome complicated with membranous nephropathy, a cause or coincidence?

Sjögren’s syndrome complicated with membranous nephropathy, a cause or coincidence?

Sjogren syndrome presenting as atrioventricular block in an adult

Comprehensive management of pregnant woman with Sjögren’s syndrome

Contact Info

Product

Resources

About