Association of allelic polymorphisms of genes matrix Gla-protein system with ischemic atherothrombotic stroke

Garbuzova, Victoria Yu.; Stroy, Dmytro; Dosenko, V.E.; Dubovyk, Yevhen Ivanovych; Borodenko, A.O.; Shimko, Kristen; Obukhova, Olha Anatoliivna; Ataman, Oleksandr Vasylovych

doi:10.15407/fz61.01.019

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…Several observational studies have reported association of MGPG-7A polymorphism with VC and CVD: calcification in aorta and coronary arteries [115], atheromatic plaque and a nearly 4-fold risk for MI [110], ischemic atheroembolic stroke [121,122,123], and acute coronary episode [124,125]. In a cohort of 438 adults aged >60 years from the general population, G-7A polymorphism was an independent predictor of plasma dpucMGP levels.…”

Section: Mgp Gene Polymorphisms Vc Mortality and Cvdmentioning

confidence: 99%

Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review

Roumeliotis

Dounousi

Eleftheriadis

et al. 2019

IJMS

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Matrix Gla Protein (MGP), a small Gla vitamin K-dependent protein, is the most powerful natural occurring inhibitor of calcification in the human body. To become biologically active, MGP must undergo vitamin K-dependent carboxylation and phosphorylation. Vitamin K deficiency leads to the inactive uncarboxylated, dephosphorylated form of MGP (dpucMGP). We aimed to review the existing data on the association between circulating dpucMGP and vascular calcification, renal function, mortality, and cardiovascular disease in distinct populations. Moreover, the association between vitamin K supplementation and serum levels of dpucMGP was also reviewed.

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Section: Mgp Gene Polymorphisms Vc Mortality and Cvdmentioning

confidence: 99%

Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review

Roumeliotis

Dounousi

Eleftheriadis

et al. 2019

IJMS

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“…Previously, we also investigated an association of VKORC1 T2255C polymorphism with IS in the same Ukrainian population [ 25 ]. It was shown that carriers of C/C genotype had a significant higher risk for IS than individuals with T/T genotype.…”

Section: Discussionmentioning

confidence: 99%

G-1639A but Not C1173TVKORC1Gene Polymorphism Is Related to Ischemic Stroke and Its Various Risk Factors in Ukrainian Population

Dubovyk

Harbuzova

Атаман

2016

BioMed Research International

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Vitamin K epoxide reductase complex subunit 1 (VKORC1) is integral 163-amino acid long transmembrane protein which mediates recycling of vitamin K 2,3-epoxide to vitamin K hydroquinone and it is necessary for activation of vitamin K-dependent proteins (VKDPs). Herein, the association between G-1639A (rs9923231) and C1173T (rs9934438) single-nucleotide polymorphisms (SNPs) of the VKORC1 gene and ischemic stroke (IS) was tested in Ukrainian population. Genotyping was performed in 170 IS patients and 124 control subjects (total 294 DNA samples) using PCR-RFLP (polymerase chain reaction with following restriction fragment length polymorphism analysis) method. Our data showed that G-1639A but not C1173T polymorphism was related to IS, regardless of adjustment for age, sex, body mass index, smoking status, and arterial hypertension. The risk for IS in -1639A allele carriers (OR = 2.138, P = 0.015) was higher than in individuals with G/G genotype. Haplotype analysis demonstrated that -1639G/1173T and -1639A/1173C were related to increased risk for IS (OR = 3.813, P = 0.010, and OR = 2.189, P = 0.011, resp.), while -1639G/1173C was a protective factor for IS (OR = 0.548, P < 0.001). Obtained results suggested that -1639A allele can be a possible genetic risk factor for IS in Ukrainian population.

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“…Harbuzova et al analyzed the role of MGP in cerebrovascular disease. They found that the AA genotype of rs1800801 was associated with an increased risk of ischemic atherothrombotic stroke in Ukrainian females [18,19]. They also reported that the AA genotype associated with an altered prothrombin time, presumably causing increased hypercoagulability [20].…”

Section: Plos Onementioning

confidence: 99%

Matrix Gla protein polymorphism rs1800801 associates with recurrence of ischemic stroke

et al. 2020

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The MGP single nucleotide polymorphism (SNP) rs1800801 has previously been associated with recurrent ischemic stroke in a Spanish cohort. Here, we tested for association of this SNP with ischemic stroke recurrence in a North American Caucasian cohort. Acute ischemic stroke patients admitted between 10/2009 and 12/2016 at three hospitals within a large healthcare system in the northeastern United States that were enrolled in a healthcare system-wide exome sequencing program were retrospectively reviewed. Patients with recurrent stroke within 1 year after index event were compared to those without recurrence. Of 9,348 suspected acute ischemic strokes admitted between 10/2009 and 12/2016, 1,727 (18.5%) enrolled in the exome-sequencing program. Among those, 1,068 patients had exome sequencing completed and were eligible for inclusion. Recurrent stroke within the first year of stroke was observed in 79 patients (7.4%). In multivariable analysis, stroke prior to the index stroke (OR 9.694, 95% CI 5.793-16.224, p � 0.001), pro-coagulant status (OR = 3.563, 95% CI 1.504-8.443, p = 0.004) and the AA genotype of SNP rs1800801 (OR = 2.408, 95% CI 1.079-4.389, p = 0.004) were independently associated with recurrent stroke within the first year. The AA genotype of the MGP SNP rs1800801 is associated with recurrence within the first year after ischemic stroke in North American Caucasians. Study of stroke subtypes and additional populations will be required to determine if incorporation of allelic status at this SNP into current risk scores improves prediction of recurrent ischemic stroke.

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Association of allelic polymorphisms of genes matrix Gla-protein system with ischemic atherothrombotic stroke

Cited by 6 publications

References 20 publications

Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review

Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review

G-1639A but Not C1173TVKORC1Gene Polymorphism Is Related to Ischemic Stroke and Its Various Risk Factors in Ukrainian Population

Matrix Gla protein polymorphism rs1800801 associates with recurrence of ischemic stroke

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