Association of ABO blood groups with ovarian reserve, and outcomes after assisted reproductive technology: systematic review and meta-analyses

Abstract

Background There has been an interest in the relationship between ABO blood groups and infertility. Many studies have investigated the association of ABO blood groups with diminished ovarian reserve (DOR), ovarian hyperstimulation syndrome (OHSS), and outcomes of assisted reproductive technology (ART), with controversial results. Methods A systematic review and meta-analysis was conducted to evaluating the association of ABO blood groups with DOR, OHSS, and outcomes of ART. Results Thirteen studies performed between 2010 and 2018 were included in this meta-analysis. DOR, OHSS, live birth rate (LBR), clinical pregnancy rate (CPR), miscarriage rate (MR) were reported in 9, 2, 4, 3, 2 studies, respectively. The combined results showed similar risk of DOR among individuals with blood group A (RR, 0.98; 95% confidence interval [CI], 0.85, 1.13), B (RR, 0.96; 95% CI, 0.76, 1.20), AB (RR, 1.00; 95% CI, 0.76, 1.30), and non-O (RR, 0.94; 95% CI, 0.79, 1.11) as compared to those with blood group O. Meta-analysis showed that the incidences of OHSS were similar in women with blood group A (RR, 1.05; 95% CI, 0.66, 1.66), B (RR, 1.04; 95% CI, 0.46, 2.35), AB (RR, 0.51; 95% CI, 0.10, 2.56), non-O (RR, 1.02; 95% CI, 0.65, 1.57) with blood group O. As to the clinical outcomes, meta-analysis showed no difference in LBR among individuals with blood group A (RR, 1.27; 95% CI, 0.74, 2.17), B (RR, 1.47; 95% CI, 0.95, 2.29), AB (RR, 1.48; 95% CI, 0.76, 2.90), non-O (RR, 1.28; 95% CI, 0.83, 1.98) when compared to those with blood group O. Similarly, the results also found that there were no difference in CPR and MR between women with blood A (CPR: RR, 1.12), B (CPR: RR, 1.08), AB (CPR: RR, 1.05), non-O (CPR: RR, 1.05; MR: RR, 0.94) and blood group O. Conclusions ABO blood groups may not be associated with DOR, OHSS, LBR, CPR, and MR of ART. Infertility and ART outcomes are influenced by multiple factors. Blood groups should not be taken into account excessively during diagnosis and treatment of infertile women.

Menopause and HRT (Use and Concerns) among Jordanian Women: A Cross Sectional Study

“…As we indicated, there is no significant relationship between the ABO blood grouping and the onset of menopause. A systematic review and meta-analysis published in 2021 reflected no effect of the ABO blood group on the diminishing of the ovarian reserve [34].…”

Are ABO/Rh blood groups A risk factor for polycystic ovary syndrome?

“…[18] In a meta-analysis examining ABO/Rh blood groups and infertility status or ovarian reserve, the opposite result was found, and it was determined that infertility and assisted reproductive technology were not affected by ABO/Rh blood groups. [19] In another study evaluating 35,479 infertile women, it was found that decreased ovarian reserve increased in women with B blood group and decreased in women with O blood group. [20] In addition, there are studies examining the relation between ovarian cancer and ABO blood groups in the literature.…”

Association of ABO blood groups with ovarian reserve: a retrospective cohort study in Chinese Han women younger than 40 years with infertility

“…Mu et al found that ABO blood type was associated with ovarian reserve in Chinese women with subfertility [ 22 ]. A meta-analysis showed that there was no significant difference in the incidence of DOR between blood group A/B/AB/non-O and blood group O [ 48 ]. Therefore, more clinical studies are needed to prove this deduction.…”