Association of abdominal aortic aneurysm diameter indexed to patient height with symptomatic presentation and mortality

Khan, Maryam Ali; Nejim, Besma; Faateh, Muhammad; Mathlouthi, Asma; Aurshina, Afsha; Malas, Mahmoud B.

doi:10.1016/j.jvs.2021.10.055

Cited by 6 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, saccular index varies by gender and race, so it might provide an individualized prediction. 84 Therefore, the saccular index may also be one of the effective evaluating indicators to predict the risk of AAA rupture.…”

Section: Saccular Indexmentioning

confidence: 99%

Narrative Review of Risk Assessment of Abdominal Aortic Aneurysm Rupture Based on Biomechanics-Related Morphology

Ren

Guidoin

et al. 2022

J Endovasc Ther

View full text Add to dashboard Cite

An abdominal aortic aneurysm (AAA) is a typical aortic disease with serious complications. In clinical practice, the decision to intervene in treatment depends on the rupture risk of AAA. Therefore, monitoring the progression of the disease and accurately assessing the rupture risk is of great importance for its treatment. Studies have shown that the biomechanical indicators based on multi-scale models are more effective in accurately assessing the rupture risk of AAA. However, using computational fluid dynamics (CFD) to simulate the biomechanical environment is a cumbersome and time-consuming process, which is inadequate to meet the needs of clinical monitoring and quick decisions. While the hemodynamic environment of AAA is heavily dependent on geometry, more and more biomechanics-related morphological parameters have been raised and validated. In this review, we summarized typical morphological parameters associated with AAA rupture and their relationships with the mechanical environment, including maximum diameter, deformation rate, saccular index, asymmetry, AAA volume, tortuosity, and intraluminal thrombus (ILT), providing a reference for clinical preoperative risk assessment. Clinical Impact Studies have shown that the biomechanical indicators based on multi-scale models are more effective in accurately assessing the rupture risk of AAA. To meet the need for clinical monitoring and rapid decision making, the typical morphological parameters associated with AAA rupture and their relationships with the mechanical environment have been summarized, which provide a reference for clinical preoperative risk assessment of AAA.

show abstract

Section: Saccular Indexmentioning

confidence: 99%

Narrative Review of Risk Assessment of Abdominal Aortic Aneurysm Rupture Based on Biomechanics-Related Morphology

Ren

Guidoin

et al. 2022

J Endovasc Ther

View full text Add to dashboard Cite

show abstract

“…4 Furthermore, recent studies have suggested that aneurysm diameter alone is not sufficient to guide AAA treatment. 5,6 Specifically, some small AAAs have a high risk of rupture, while some large AAAs can remain dormant for long periods. 7−9 Importantly, there is a lack of AAA prognostic markers.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Despite clear guidelines regarding AAA screening and surveillance, current follow-up and management remain poor, and many patients with ruptured AAA require emergency surgery . Furthermore, recent studies have suggested that aneurysm diameter alone is not sufficient to guide AAA treatment. , Specifically, some small AAAs have a high risk of rupture, while some large AAAs can remain dormant for long periods. − …”

Section: Introductionmentioning

confidence: 99%

Identification and Evaluation of Blood-Based Biomarkers for Abdominal Aortic Aneurysm

Li,

Khan,

Shaikh

et al. 2024

J. Proteome Res.

View full text Add to dashboard Cite

Introduction: Blood-based biomarkers for abdominal aortic aneurysm (AAA) have been studied individually; however, we considered a panel of proteins to investigate AAA prognosis and its potential to improve predictive accuracy. Materials and methods: Using a prospectively recruited cohort of patients with/without AAA (n = 452), we conducted a prognostic study to develop a model that accurately predicts AAA outcomes using clinical features and circulating biomarker levels. Serum concentrations of 9 biomarkers were measured at baseline, and the cohort was followed for 2 years. The primary outcome was major adverse aortic event (MAAE; composite of rapid AAA expansion [>0.5 cm/6 months or >1 cm/12 months], AAA intervention, or AAA rupture). Using 10-fold cross-validation, we trained a random forest model to predict 2 year MAAE using (1) clinical characteristics, (2) biomarkers, and (3) clinical characteristics and biomarkers. Results: Two-year MAAE occurred in 114 (25%) patients. Two proteins were significantly elevated in patients with AAA compared with those without AAA (angiopoietin-2 and aggrecan), composing the protein panel. For predicting 2 year MAAE, our random forest model achieved area under the receiver operating characteristic curve (AUROC) 0.74 using clinical features alone, and the addition of the 2-protein panel improved performance to AUROC 0.86. Conclusions: Using a combination of clinical/biomarker data, we developed a model that accurately predicts 2 year MAAE.

show abstract

“…Hence, there is a lack of contemporary correct prevalence data for AAA in women 8 . With increasing attention drawn to influential gender differences in the care trajectory of AAA patients, an improved knowledge of standard aortic measurements can increase the quality of care 9 , 10 . In recent years, the 30 mm definition of AAA has been challenged, especially for women, and possible alternatives are consideration of the person’s body surface area and the aortic size (aortic size index, ASI), as well as aortic height index (AHI).…”

Section: Introductionmentioning

confidence: 99%

“…Consideration of ASI and AHI in women compared with men could improve the precision in surveillance rather than only basing surveillance on maximum diameter. An expanded surveillance regime for sub-aneurysmal aortas (SAA; 25–29 mm) is reported in selected vascular clinics 10–12 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of abdominal aortic aneurysm (AAA) in first-degree relatives: detecting AAA in adult offspring of AAA patients

Fattahi,

Linné,

Roy

et al. 2024

BJS Open

View full text Add to dashboard Cite

Background First-degree relatives of patients with abdominal aortic aneurysm (AAA) may have an increased risk of developing the disease. The primary aim was to report the prevalence of AAA in adult male and female offspring of patients with AAA. The secondary aim was to explore the efficiency of a registry-based detection route, and the third aim was to report contemporary prevalence in the population. Methods Adult offspring of individuals with AAA and matched controls were identified through national registries. The examination included questionnaires and ultrasound examinations of the infrarenal aorta. Aortic pathology was defined as an aortic diameter ≥25 mm, AAA ≥30 mm. Results The participation rate among male and female adult offspring was 64% (350/543) and 69% (402/583), respectively. A lower participation rate was found in male and female controls (51% and 52%). No difference in prevalence of AAA was observed between male adult offspring and controls (0.9%, c.i. 0.2 to 2.3%) or in the female population (prevalence of 0.2% in adult offspring and controls). Aortic pathology and previously diagnosed AAA were detected in 5.3% (c.i. 3.3 to 8.0%) of male adult offspring and 2.3% (c.i. 1.1 to 4.2%) in controls. Aortic pathology was more prevalent among adult offspring of females with AAA. Conclusion The prevalence of AAA in the general population is low, but aortic pathology is notably higher among male first-degree relatives. Increased awareness should be directed towards individuals with a possible hereditary predisposition, particularly offspring of females with AAA and older smokers. Risk factor-based targeted screening of adult offspring of patients with AAA after registry-based detection should be further explored. Trial registration ClinicalTrials.gov identifier, NCT4623268

show abstract

Association of abdominal aortic aneurysm diameter indexed to patient height with symptomatic presentation and mortality

Cited by 6 publications

References 29 publications

Narrative Review of Risk Assessment of Abdominal Aortic Aneurysm Rupture Based on Biomechanics-Related Morphology

Narrative Review of Risk Assessment of Abdominal Aortic Aneurysm Rupture Based on Biomechanics-Related Morphology

Identification and Evaluation of Blood-Based Biomarkers for Abdominal Aortic Aneurysm

Prevalence of abdominal aortic aneurysm (AAA) in first-degree relatives: detecting AAA in adult offspring of AAA patients

Contact Info

Product

Resources

About