volume 39, issue 37, P3417-3438 2018
DOI: 10.1093/eurheartj/ehy407
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Abstract: AbstractAimsTreatment ‘effects’ are often inferred from non-randomized and observational studies. These studies have inherent biases and limitations, which may make therapeutic inferences based on their results unreliable. We compared the conflicting findings of these studies to those of prospective randomized controlled trials (RCTs) in relation to pharmacological treatments for heart failure (HF).Methods and resultsWe searched Medline and Embase to identify studies of the association between non-randomized d…

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