Association Between Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality

Bi, Wei Guang; Nuyt, Anne Monique; Weiler, Hope A.; Leduc, Line; Santamaria, Christina; Wei, Shu Qin

doi:10.1001/jamapediatrics.2018.0302

Cited by 136 publications

(111 citation statements)

References 61 publications

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“…One theme dominating the literature on maternal VDD is its influence on fetal growth. Although, the specific effects of maternal VDD on fetal growth are dependent on the severity and timing of the deficiency, the preponderance of data show VDD is associated with decreased birth weight and higher risk for 'small for gestational age' (SGA) (Leffelaar et al , Burris et al 2012, Schneuer et al 2014, Eckhardt et al 2015, Miliku et al 2016, Bi et al 2018. This influence complicates the interpretation of results examining the prenatal programming effects of maternal VDD since fetal growth restriction, regardless of its origin, and its subsequent 'catch-up' weight gain are also well known to be related to metabolic health complications (Hales & Ozanne 2003).…”

Section: Important Considerationsmentioning

confidence: 99%

Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)

Ideraabdullah

Belenchia

Rosenfeld

et al. 2019

Journal of Endocrinology

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Vitamin D is an essential nutrient that is metabolized in the body to generate an active metabolite (1,25(OH)2D) with hormone-like activity and highly diverse roles in cellular function. Vitamin D deficiency (VDD) is a prevalent but easily preventable nutritional disturbance. Emerging evidence demonstrates the importance of sufficient vitamin D concentrations during fetal life with deficiencies leading to long-term effects into adulthood. Here, we provide a detailed review and perspective of evidence for the role of maternal VDD in offspring long-term health, particularly as it relates to developmental origins of health and disease (DOHaD). We focus on the roles in neurobehavioral and cardiometabolic disorders in humans and highlight recent findings from zebrafish and rodent models that probe potential mechanisms linking early life VDD to later life health outcomes. Moreover, we explore evidence implicating epigenetic mechanisms as a mediator of this link. Gaps in our current understanding of how maternal VDD might result in deleterious offspring outcomes later in life are also addressed.

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Section: Important Considerationsmentioning

confidence: 99%

Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)

Ideraabdullah

Belenchia

Rosenfeld

et al. 2019

Journal of Endocrinology

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“…The institute of medicine recommendations suggest a normal level of 20 ng/ml in pregnancy, while the endocrine society recommends 30 ng/ml or more. 29,30 A circulating level of 25-hydroxyvitamin D of >75 nmol/l, or 30 ng/ml, is required to maximize beneficial effects of vitamin D on health. 31 The recommended daily intake of vitamin D ranges from 400 to 600 IU (by the IOM) 400 IU (by the National Institute for Health and Clinical Excellence, United Kingdom) and to 1500-2000 IU (by the endocrine society) and 2000 IU (by the Canadian society).…”

Section: Recommended Daily Dose According To Researchmentioning

confidence: 99%

“…41 Vitamin D regulates genes responsible for trophoblastic invasion and angiogenesis critical for placental implantation and function which is important for foetal growth. 29 Vitamin supplementation in pregnancy reduces the risk of low birth weight (2500 g) by 60%. 27 Vitamin D supplementation during pregnancy is associated with a reduced risk of SGA and improved infant growth without risk of foetal or neonatal mortality or congenital abnormality.…”

Section: Birth Weight and Anthropometrymentioning

confidence: 99%

“…27 Vitamin D supplementation during pregnancy is associated with a reduced risk of SGA and improved infant growth without risk of foetal or neonatal mortality or congenital abnormality. 29 This implies that maternal deficiency of vitamin D during pregnancy affects the foetus, with known consequences on foetal growth, dentition, bone density and anthropometry. 23,41…”

Section: Birth Weight and Anthropometrymentioning

confidence: 99%

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Importance of vitamin D supplementation in pregnancy-review

Dkhar

Ashraf

Hassan

2019

Int J Community Med Public Health

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Pregnancy is a state that leads to several deficiency and increased demand of essential nutrients for the growing foetus. In one such case it is seen that vitamin D deficiency can lead to severe outcome in the new-born as well as the mother. Vitamin D travels to the foetus by passive transfer and the foetus is entirely dependent on maternal stores. Therefore it becomes all the more essential to know your vitamin D level during antenatal period to prevent adverse outcomes. Vitamin D supplementation helps in preventing the outcomes like rickets, low birth weight, bone and dental deformity in foetus, decreased immunity and impaired lung function in children, whereas also helping in decreased incidence of primary caesarean sections, preeclampsia, gestational diabetes mellitus in mother. The recommended dose has been described up to 2000IU/day as a supplementation and not therapeutic dose, which is found to be safe and effective.

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“…Articles were excluded if they were not published in English, full text was unavailable (1 article), did not evaluate infant vitamin D status in relation tomaternal supplementation with vitamin D, evaluated more than one micronutrient or were commentaries on previous studies. Articles were also excluded if they examined vitamin D supplementation during pregnancy since the association between vitamin D supplementation during pregnancy and offspring vitamin D status and outcomes has been the subject of a current systematic review and meta-analysis[14].…”

mentioning

confidence: 99%

Maternal Supplementation of Vitamin D During Lactation to Support Infant Vitamin D Needs: A Systematic Review

Schossow¹,

Clark²,

Harris³

2018

OJPed

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Human milk is generally considered to be insufficient in vitamin D. However, research completed in the 1980s showed that the vitamin D content of human milk is directly related to maternal serum vitamin D levels and therefore may potentially be adequate if the mother's vitamin D levels are sufficient. Approximately one-third of the adult population, which includes breastfeeding women, in the United States have vitamin D insufficiency or deficiency. Among infants, 90.4% of breastfed infants are vitamin D deficient compared to 15.4% of formula fed infants. The American Academy of Pediatrics (AAP) has therefore recommended all breastfed infants be directly supplemented with 400 IU per day of vitamin D to decrease the risk of vitamin D insufficiency and rickets. According to the AAP, compliance rates with this recommendation ranges between 2% -36%. Because the recommendation to supplement may undermine breastfeeding, many pediatricians do not inform their patients of the need to supplement. Additionally, some parents are concerned about directly supplementing their infant as risks may include allergic reactions to the ingredients, aspiration pneumonia, accidental overdose, and changes in intestinal flora and pH which may compromise the immune benefits of human milk. A literature review was conducted to examine the effect of maternal supplementation with vitamin D during lactation on human milk vitamin D content and maternal and infant serum vitamin D levels. Although there is no current consensus regarding dosage and timing of maternal vitamin D supplementation, the literature suggests that high-dose vitamin D supplementation of the lactating mother is as effective at maintaining infant vitamin D levels as direct infant supplementation, while also correcting the mother's vitamin D deficiency. How to cite this paper: Schossow, K., Clark, A.M. and Harris, M.A. (2018) Maternal Supplementation of Vitamin D during Lactation to Support Infant Vitamin D Needs: A Systematic Review. Open Journal of Pediatrics, 8, 255-272.

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Association Between Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality

Cited by 136 publications

References 61 publications

Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)

Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)

Importance of vitamin D supplementation in pregnancy-review

Maternal Supplementation of Vitamin D During Lactation to Support Infant Vitamin D Needs: A Systematic Review

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