Association between vitamin D insufficiency and adverse pregnancy outcome: global comparisons

Bener, Abdülbari; Al-Hamaq, Abdulla O.A.A.; Saleh, N.

doi:10.2147/ijwh.s51403

Cited by 107 publications

(95 citation statements)

References 39 publications

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“…This was also observed by Bener, et al; [10] where the risk of vitamin D deficiency was higher among young pregnant women below 30 years old and Bowyer, et al [11] in Australia where younger maternal age was associated with lower maternal serum 25-OHD (≤ 25 nmol/l) [(OR, 95% CI) 0·93 (0·89-0·97, P = 0·001)]. However, Maghbooli, et al; [16] and El koumi, et al; [23] found no significant correlation between maternal serum vitamin D concentration with age (P = 0.2).…”

Section: Resultssupporting

confidence: 84%

Study of Association Between Maternal 25 – hydroxy Vitamin D3 Level and Neonatal Outcome

Rajoria¹,

Gupta²,

Rajoria³

et al. 2016

SJAMS

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Abstract:The widespread global prevalence of hypovitaminosis D during pregnancy and its implications for undesirable health outcomes in present and future generations is an area of growing concerns. The study was undertaken with an aim to determine vitamin D status among pregnant women and their new-borns and to find association between maternal vitamin D level during pregnancy and neonatal outcome. This hospital based, observational study was conducted on 250 pregnant patients and their new-borns in departments of Obstetrics & Gynaecology and Paediatrics at SMS Medical College, Jaipur from May 2014 to April 2015. Maternal and cord blood samples were drawn at the time of delivery for 25-hydroxy vitamin D, S. calcium, S. phosphorus and S. ALP levels estimation. 86% of women were vitamin D deficient, 12.4% insufficient and only 1.6% had sufficient vitamin D levels. Their new born also showed similar results. Mean neonatal vitamin D level in vitamin D deficient , insufficient , sufficient mothers were 5.73 ± 2.7 ng/ml, 17.77 ± 9.62 ng/ml and 33.09 ± 5.22 ng/ml respectively. Maternal and cord blood vitamin D levels showed significant positive correlation (r = 0.90, P value < 0.001). Maternal Vitamin D status was not significantly associated with neonatal biochemical parameters (S. calcium, S. phosphorus and S. ALP levels) and anthropometry. The strong correlation between 25(OH) D concentrations in mothers and their new-borns indicate that adequate vitamin D intake for mothers should be emphasized through maternal supplementation which would achieve the double effect of preventing vitamin D deficiency in both mothers and children.

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Section: Resultssupporting

confidence: 84%

Study of Association Between Maternal 25 – hydroxy Vitamin D3 Level and Neonatal Outcome

Rajoria¹,

Gupta²,

Rajoria³

et al. 2016

SJAMS

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“…Total physical activity significantly correlated with severe vitamin D deficiency, which has been shown in previous studies of pregnant women in other countries (47,48). This correlation is observed because physical activity levels reflect the amount of exposure to sunlight in some degree.…”

Section: Discussionsupporting

confidence: 77%

Demographic and Lifestyle Factors Associated with Vitamin D Status in Pregnant Japanese Women

Shiraishi

Haruna

Matsuzaki

et al. 2014

J Nutr Sci Vitaminol

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Vitamin D has drawn attention as a significant nutrient to prevent pregnancy complications and health problems in offspring (1, 2). For instance, maternal vitamin D deficiency has been speculated to cause endothelial dysfunction, a key feature of preeclampsia, through a proinflammatory response and increase in oxidative stress (3). Its deficiency also leads to low birth size through the inhibition of bone mineral accrual of the fetus (4).Maintaining maternal circulating 25-hydroxyvitamin D (25(OH)D) concentrations above 30.0 ng/mL is recommended (5). However, the high ratio of severe vitamin D deficiency (25(OH)D,10.0 ng/mL) in pregnant women is a significant concern in many countries (6-8). In Japan, two studies showed that the mean serum 25(OH)D concentrations during pregnancy were only 9.5-14.5 ng/mL (9, 10). The concentrations were especially lower in winter. To improve the vitamin D status of pregnant Japanese women, identification of populations at a high risk of vitamin D deficiency and implementation of appropriate intervention are necessary. In general, vitamin D status depends on vitamin D intake (vitamin D21D3) and vitamin D3 production in the skin through exposure to sunlight (11). Although vitamin D status was reported to be affected by age, body mass index (BMI), physical activity, and season (12-15), factors associated with vitamin D status vary with the target population and latitude. Among pregnant Australian women, low serum 25(OH)D concentrations were significantly predicted by non-Caucasian, high BMI, non-use of vitamin D supplements, and winter season (14). Among non-pregnant Japanese women, young age, low dietary vitamin D intake, low walk counts, and long sedentary activity time correlated with low serum 25(OH)D concentrations (16,17). The walk counts and sedentary activity time were presumed to reflect the amount of exposure to sunlight. However, it remains unclear which factors are associated with vitamin D status in pregnant Japanese women, the extent to which those factors are associated with vitamin D status, and whether the factors vary with the season.The objective of the present study was to examine demographic and lifestyle factors associated with

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“…Higher rates of severe vitamin D deficiency were previously reported in the literature from Turkey 10,17 . Those prior studies have shown that covered dress style may be an important factor affecting the prevalence of vitamin D deficiency in Muslim populations due to the religious and cultural reasons 10,18. The prevalence of low vitamin D levels was greater in cases which were sampled in winter, in women who had limited access to sunlight, those living in countries at higher latitudes and those with higher skin pigmentation 16,[18][19][20] . In a study by Perez et al, 21 it was observed that only 35.9% of pregnant women in the first trimester had adequate serum 25(OH)D levels (≥30 ng/mL) and non-Caucasian ethnicity, season at sampling (autumn/winter) and nulliparity were found to be associated with 25(OH)D deficiency.…”

Section: Discussionmentioning

confidence: 93%

Vitamin D status in the first-trimester: effects of Vitamin D deficiency on pregnancy outcomes

Ates¹,

Şevket²,

Özcan³

et al. 2016

Afr H. Sci.

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Objective: To assess serum levels of in the first trimester and to determine the factors affecting deficiency levels and its association with pregnancy outcomes. Methods: Serum 25(OH)D concentrations were measured at 11-14 weeks' gestation in 229 singleton pregnancies using liquid chromatography-tandem mass spectrometry. Results: The median serum 25(OH)D concentration was 10.8 ng/mL and 45.9% of women had severe vitamin D deficiency with concentrations of <10 ng/mL. Logistic regression analysis revealed that covered dressing style, lack of multivitamin intake, season of blood sampling (November-April) were factors associated with 25(OH)D deficiency. There was a negative correlation between 25(OH)D levels and gestational age at sampling. Low 25(OH)D levels were not associated with adverse pregnancy outcomes. Higher rate of cesarean section (CS) was noted in women with 25(OH)D ≥10 ng/mL compared to those with 25(OH)D < 10mg/ml ( p= 0.01). Conclusion: A high prevalence of vitamin D deficiency was observed in early pregnancy which was related to dress code, use of multi-vitamins and season at sampling. Low 25(OH)D levels were not related with adverse pregnancy outcomes. Women with severe vitamin D deficiency were more likely to deliver vaginally.

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Association between vitamin D insufficiency and adverse pregnancy outcome: global comparisons

Cited by 107 publications

References 39 publications

Study of Association Between Maternal 25 – hydroxy Vitamin D3 Level and Neonatal Outcome

Study of Association Between Maternal 25 – hydroxy Vitamin D3 Level and Neonatal Outcome

Demographic and Lifestyle Factors Associated with Vitamin D Status in Pregnant Japanese Women

Vitamin D status in the first-trimester: effects of Vitamin D deficiency on pregnancy outcomes

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