Association between urinary cadmium and chronic musculoskeletal pain in residents of cadmium-contaminated area in Northwest Thailand

La-up, Aroon; Wiwatanadate, Phongtape; Uthaikhup, Sureeporn; Pruenglampoo, Sakda

doi:10.1007/s11356-018-1665-3

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…The survey showed that for the cadmium-contaminated areas in northwest Thailand, people had high risk of being trapped in chronic musculoskeletal pain. This finding in turn suggests that exposure to cadmium, which is contained in EC vaping, may cause chronic musculoskeletal pain [34].…”

Section: Compounds and Potential Painsmentioning

confidence: 98%

“…Meanwhile, propylene glycol could attenuate the adverse effects of high-dose nicotine and allow EC users to develop high tolerance toward EC products [33]. By analyzing urinary cadmium levels, La-Up et al [34] found there was a positive relationship between urinary cadmium level and chronic musculoskeletal pain. The survey showed that for the cadmium-contaminated areas in northwest Thailand, people had high risk of being trapped in chronic musculoskeletal pain.…”

Section: Compounds and Potential Painsmentioning

confidence: 99%

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Pain Associated with the Use of Electronic Cigarettes

Tang¹

2019

Smoking - Prevention, Cessation and Health Effects

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Hitherto, lots of efforts have been made to illustrate the consequence of consuming conventional cigarette. The relationship between its utilization and the occurrence, deterioration, and variation of pain has been demonstrated for decades. As a result, electronic cigarette was investigated for its harmless and ideal replacement for conventional cigarette. Proposed and endorsed for almost 15 years, ecigarette has established its success and induced many consumers. Later on, with greater attention to the increasing population indulging in or switching to electronic cigarette, complaints and side effects occurred and accumulated. Betwixt, headache, chest pain, thermal injury, withdrawal symptoms, and chronic pain had been described either via case reports or by experimental or clinical researches. Through comprehensively reviewing current publications, this chapter illustrates respective pain. With the introduction of this chapter, it will be helpful for the general public to understand the potential health implications of using e-cigarettes and evoke the readers' interest to learn more about this topic.

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Section: Compounds and Potential Painsmentioning

confidence: 98%

Section: Compounds and Potential Painsmentioning

confidence: 99%

Pain Associated with the Use of Electronic Cigarettes

Tang¹

2019

Smoking - Prevention, Cessation and Health Effects

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“…La-Up et al found a positive association between urinary Cd concentrations and chronic musculoskeletal pain, suggesting that Cd exposure may cause neurological damage or damage to musculoskeletal tissue, resulting in chronic pain. In addition, Cd induces oxidative stress, which is associated with chronic muscular pain [ 46 ]. Ibrahim et al also confirmed a positive correlation between the increased incidence of musculoskeletal complaints, bone pain, joint pain and muscle spasms and Cd levels in the blood and urine among Cd-exposed workers compared to a control group [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Concentration of Selected Macronutrients and Toxic Elements in the Blood in Relation to Pain Severity and Hydrogen Magnetic Resonance Spectroscopy in People with Osteoarthritis of the Spine

Jakoniuk

Kochanowicz

Lankau

et al. 2022

IJERPH

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Macronutrients and toxic elements may play an important role in the pathogenesis of osteoarthritis of the spine. The objective of this study was to evaluate the relationship between the concentrations of Ca, Mg, Pb, Cd and Hg in blood with the results of hydrogen magnetic resonance spectroscopy and the severity of pain. Patients with osteoarthritis of the spine (n = 90) and control subjects (n = 40) were studied. The concentrations of mineral components in blood were determined by atomic absorption spectrometry (ASA). Spinal pain severity was assessed using the Visual Analog Scale (VAS). Hydrogen magnetic resonance spectroscopy (1H-MRS) was used to determine the fat/water ratio in the bodies of L1, L5 and the L4/5 intervertebral disc. The median concentration of Mg in the serum of subjects with spinal degenerative disease was significantly lower (p < 0.001) than that in healthy subjects. The median concentration of Cd in the blood of subjects with osteoarthritis of the spine was significantly higher (p < 0.05) than that in the control group. Significantly lower (p < 0.05) median molar ratios of Ca to Cd and Pb as well as Mg to Pb and Cd were observed among patients with osteoarthritis of the spine. Significant differences (p < 0.05) were observed in the value of the fat/water ratio in selected spinal structures, depending on normal or abnormal serum Ca and Mg concentrations. The study showed some abnormal macronutrient concentrations, as well as disturbed ratios of beneficial elements to toxic elements in the blood of people with osteoarthritis of the spine.

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“…Exposure to environmental cadmium poses many public health problems, as it is a highly toxic substance that can cause important adverse health effects [33][34][35]. At high doses, cadmium is known to cause the so-called itai-itai disease whose dominant symptom is back pain [36].…”

Section: Plos Onementioning

confidence: 99%

An exploratory identification of biological markers of chronic musculoskeletal pain in the low back, neck, and shoulders

et al. 2022

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Objectives This study was an in-depth exploration of unique data from a nationally representative sample of adults living in the United States to identify biomarkers associated with musculoskeletal pain. Methods We performed secondary analyses of 2003–2004 NHANES data. After a first screening of 187 markers, analyses of 31 biomarkers were conducted on participants aged ≥20 years identified in all counties using the 2000 Census Bureau data (n = 4,742). To assess the association of each biomarker with each pain outcome (acute, subacute and chronic low back, neck, and shoulder pain), analyses were carried out using multivariable logistic regression with adjustments for sex, age and body mass index. Biomarkers were considered as continuous variables and categorized at the median of their distributions. Results Pain at any site for ≥24 hours during the past month was reported by 1,214 participants. Of these, 779 mentioned that the pain had lasted for ≥3 months (“chronic pain”). α-carotene, ascorbic acid, β-carotene, mercury and total protein had a statistically significant, inverse association with ≥2 chronic pain sites. Acrylamide, alkaline phosphatase, cadmium, cotinine, glycidamide, homocysteine, retinol, triglycerides and white blood cell count were positively associated with ≥2 chronic pain sites. Few biological markers were associated with acute and subacute pain. Conclusions This study identified some biomarkers that were strongly and consistently associated with musculoskeletal pain. These results raise new hypotheses and could have tremendous implications for advancing knowledge in the field. Research on musculoskeletal pain needs to put more effort on the biological dimension of the biopsychosocial model of pain.

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Association between urinary cadmium and chronic musculoskeletal pain in residents of cadmium-contaminated area in Northwest Thailand

Cited by 5 publications

References 24 publications

Pain Associated with the Use of Electronic Cigarettes

Pain Associated with the Use of Electronic Cigarettes

Concentration of Selected Macronutrients and Toxic Elements in the Blood in Relation to Pain Severity and Hydrogen Magnetic Resonance Spectroscopy in People with Osteoarthritis of the Spine

An exploratory identification of biological markers of chronic musculoskeletal pain in the low back, neck, and shoulders

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