Association Between Urinary Bisphenol A Concentration and Obesity Prevalence in Children and Adolescents

Trasande, Leonardo; Attinà, Teresa M.; Blustein, Jeffrey

doi:10.1001/2012.jama.11461

Cited by 410 publications

(320 citation statements)

References 40 publications

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“…6,8,127 Research indicates that BPA has estrogenic properties, can interfere with endocrine signaling pathways, and may affect energy balance and glucose homeostasis. 8,127,139 BPA was measured in spot urine samples collected from pregnant women and children at ages 5 and 9 years as part of the CHAMACOS study.…”

Section: Metalsmentioning

confidence: 99%

“…142,143 A cross-sectional study examining NHANES data (2003)(2004)(2005)(2006)(2007)(2008) found that urinary BPA concentrations were significantly associated with obesity in children and adolescents after controlling for several cofactors. 6 Another study using the NHANES data reported that non-Hispanic white boys were more likely to be overweight/obese, independent of other major risk factors, as a result of exposure to BPA. 144 To support these associations, more research is needed using longitudinal studies to confirm the findings observed in the available cross-sectional studies.…”

Section: Metalsmentioning

confidence: 99%

“…144 To support these associations, more research is needed using longitudinal studies to confirm the findings observed in the available cross-sectional studies. 6,[142][143][144] Phthalates are a group of man-made chemicals widely used in industrial and consumer product applications. 8,145,146 Exposure to phthalates can occur from food sources, plastic containers, flooring materials and wall coverings, medical devices, personal care products, lacquers, varnishes, and coatings.…”

Section: Metalsmentioning

confidence: 99%

“…Much research has been undertaken to study the link between any one individual factor and obesity. [6][7][8][9][10][11][12][13][14] For example, metabolic risk factors such as diabetes have been shown to be linked to obesity, and there is growing research exploring the associations between chemical exposures and diabetes. 15,16 However, the inter-relationships between stressors are not well understood.…”

Section: Introductionmentioning

confidence: 99%

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Chemical and non-chemical stressors affecting childhood obesity: a systematic scoping review

Lichtveld

Thomas

Tulve

2017

J Expo Sci Environ Epidemiol

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Childhood obesity in the United States has doubled over the last three decades and currently affects 17% of children and adolescents. While much research has focused on individual behaviors impacting obesity, little research has emphasized the complex interactions of numerous chemical and non-chemical stressors found in a child's environment and how these interactions affect a child's health and well-being. The objectives of this systematic scoping review were to (1) identify potential chemical stressors in the context of non-chemical stressors that impact childhood obesity; and, (2) summarize our observations for chemical and non-chemical stressors in regards to child-specific environments within a community setting. A review was conducted to identify chemical and non-chemical stressors related to childhood obesity for the childhood life stages ranging from prenatal to adolescence. Stressors were identified and grouped into domains: individual behaviors, family/household behaviors, community stressors, and chemical exposures. Stressors were related to the child and the child's everyday environments and used to characterize child health and well-being. This review suggests that the interactions of chemical and non-chemical stressors are important for understanding a child's overall health and well-being. By considering these relationships, the exposure science research community can better design and implement strategies to reduce childhood obesity.

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Section: Metalsmentioning

confidence: 99%

Section: Metalsmentioning

confidence: 99%

Section: Metalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chemical and non-chemical stressors affecting childhood obesity: a systematic scoping review

Lichtveld

Thomas

Tulve

2017

J Expo Sci Environ Epidemiol

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“…Epidemiologists jumped into the fray, too. They found associations between urine BPA levels and obesity in children 8 , and linked other endocrine disrupters to incidence of diabetes 9 . Their studies, and many others, depict a weird world of endocrine disruption that is as different from traditional toxicology as quantum mechanics is from the staid clockwork of Newtonian physics.…”

Section: Early Signsmentioning

confidence: 99%

Toxicology: The learning curve

Fagin

2012

Nature

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Researchers say that some chemicals have unexpected and potent effects at very low doses -but regulators aren't convinced.N ear the end of an adventurous life spent wandering the fortress towns of central Europe, clashing with bloodletters and other tradition-bound healers of the day, the irascible sixteenth-century physician Paracelsus wrote a defence of his unorthodox use of mercury, opium and other potentially dangerous medicines. "All things are poison, and nothing is without poison: the dose alone makes a thing not poison, " he wrote. Centuries later, after many of his once-radical ideas found wide acceptance, Paracelsus's pronouncement would be distilled into a pithy phrase that became foundational dogma for the modern science of toxicology: "the dose makes the poison. "The contemporary interpretation of Paracelsus's famous declaration, for which he is often called the father of toxicology, is that dose and effect move together in a predictably linear fashion, and that lower exposures to a hazardous compound will therefore always generate lower risks. This idea is not just a philosophical abstraction; it is the core assumption underlying the system of chemical-safety testing that arose in the mid-twentieth century. Risk assessors typically look for adverse effects of a compound over a range of high doses and, from there, extrapolate downwards to establish health standards -always assuming, like Paracelsus, that chemicals toxic at high doses are much less risky at lower, real-world levels.

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Progress in Obesity Research

Livingston¹,

Zylke²

2012

JAMA

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Association Between Urinary Bisphenol A Concentration and Obesity Prevalence in Children and Adolescents

Cited by 410 publications

References 40 publications

Chemical and non-chemical stressors affecting childhood obesity: a systematic scoping review

Chemical and non-chemical stressors affecting childhood obesity: a systematic scoping review

Toxicology: The learning curve

Progress in Obesity Research

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