Association between Urinary 8-Hydroxydeoxyguanosine, an Indicator of Oxidative Stress, and the Cardio-Ankle Vascular Index in Hypertensive Patients

Masugata, Hisashi; Senda, Shoichi; Murao, Koji; Inukai, Michio; Himoto, Takashi; Hosomi, Naohisa; Okada, Hiroki; Goda, Fuminori

doi:10.5551/jat.12716

Cited by 19 publications

(17 citation statements)

References 30 publications

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“…Our results were partly in agreement with a recent study by Masugata et al, which found a positive correlation between 8-OHdG and the cardio-ankle vascular index in patients with HT, (19) and with other earlier studies that reported that the role of 8-OHdG could be amplified in the hypertensive state when compared to the diabetic state. (14,37) Various possible biological mechanism(s) may be fundamental to the correlation between urinary 8-OHdG levels and PWV in T2DM patients with HT (Fig.…”

Section: Discussionsupporting

confidence: 83%

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Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus

Kotani

Yamada²

2014

smedj

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The Asia-Pacific region is facing an epidemic of type 2 diabetes mellitus (T2DM), paralleled by high rates of cardiovascular disease (CVD).(1,2) Hypertension (HT) remains a major risk factor for CVD in the region. On DNA oxidation, a hydroxyl group is added to the guanine molecule to form 8-hydroxyguanine, which on oxidative modification yields the product, 8-hydroxy-2'-deoxyguanosine (8-OHdG). (7,8) Hyperglycaemia promotes glucose oxidation and protein glycation, impairs DNA repair with resultant DNA cleavage, and generates reactive oxygen species, thereby leading to increased oxidative stress. (4,7,8) Similarly, HT is accompanied by the formation of advanced glycation end products, and thereby increased oxidative stress and DNA damage. (9,10) For these reasons, the measurement of 8-OHdG has been used by various researchers to evaluate the DNA oxidation associated with the pathophysiology of T2DM and HT. (4,(11)(12)(13)(14)(15)(16) A study by Nishikawa et al found that urinary 8-OHdG levels were increased in T2DM patients with poor glycaemic control, (4) while a study by Espinosa et al reported that urinary 8-OHdG levels were increased in patients with HT.However, Roselló-Lletí et al demonstrated that patients with HT and DM do not exhibit any differences with regard to 8-OHdG levels when compared to patients with HT but no DM.Espinosa et al also reported that 8-OHdG levels were reduced following antihypertensive treatment in patients with HT.(13) Studies suggest lowered urinary 8-OHdG levels upon intervention with antidiabetic agents in T2DM patients, Barengo and Tuomilehto reported that the presence of HT as a comorbidity in the hyperglycaemic state increased CVD

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Section: Discussionsupporting

confidence: 83%

“…(14) Masugata et al, on the other hand, found a positive correlation between urinary 8-OHdG and the cardio-ankle vascular index in patients with HT. (19) However, this study did not compare findings in patients with HT against patients without HT or patients with DM.…”

Section: Introductionmentioning

confidence: 88%

Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus

Kotani

Yamada²

2014

smedj

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“…Previous studies have reported that CAVI was associated with the arterial stiffness parameter beta, independently of blood pressure. 38 Because CAVI is a useful tool for assessing the contraction of P<0.05), logNT-proBNP (r=0.27, P<0.05), and E' (r=−0.42, P<0.01), and E/E' (r=0.38, P<0.05) but not with FT4 and TSH (Figures 1-3, Upper). In the control group, CAVI was significantly associated with logNT-proBNP (r=0.48, P<0.001) and E' (r=−0.47 P<0.01) but not with FT3, FT4, TSH, CRP, or E/E' In the control group, CAVI was significantly associated with E' (r=−0.47, P<0.01) but not with E/E'.…”

Section: Subclinical Hypothyroidism and Arterial Stiffnessmentioning

confidence: 99%

Elevated Arterial Stiffness and Diastolic Dysfunction in Subclinical Hypothyroidism

Miyamoto

Komamura

Goda

et al. 2014

Circ J

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“…In our study population, however, no blood lipid parameters were associated with the ageadjusted CAVI ( Table 2). In concordance with these results, several studies have failed to detect a significant association between the CAVI and blood lipid levels [36][37][38] . Higashiyama et al 36) reported that the CAVI is more strongly correlated with the high-sensitivity C-reactive protein (hs-CRP) level than with the LDL cholesterol level.…”

Section: Resultsmentioning

confidence: 51%

“…Higashiyama et al 36) reported that the CAVI is more strongly correlated with the high-sensitivity C-reactive protein (hs-CRP) level than with the LDL cholesterol level. Furthermore, Masugata et al 37) demonstrated that the CAVI is independently associated with the urinary 8-hydroxydeoxyguanosine (8-OHdG) level, but not any blood lipid parameters, in hypertensive patients. The hs-CRP and 8-OHdG levels are indicators of chronic inflammation and oxidative stress, respectively, and a high CRF is associated with low levels of these indicators 39,40) .…”

Section: Resultsmentioning

confidence: 99%

Cardiorespiratory Fitness is a Strong Predictor of the Cardio-ankle Vascular Index in Hypertensive Middle-aged and Elderly Japanese Men

Tanisawa

Ito

Sun

et al. 2015

JAT

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Aim: This study aimed to examine whether cardiorespiratory fitness (CRF) is associated with arterial stiffening, evaluated using the cardio-ankle vascular index (CAVI), independent of visceral fat (VF) in middle-aged and elderly Japanese men. We also examined whether the relationship between CRF and the CAVI is modified by age and/or hypertension. Methods: The CAVI was determined in 157 Japanese men (age range, 30-79 years), including 96 hypertensive subjects (61.1%). CRF was assessed by measuring the peak oxygen uptake (V 4 O2peak). The subjects were divided into low-and high-CRF groups, and the VF area was assessed using magnetic resonance imaging.

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Association between Urinary 8-Hydroxydeoxyguanosine, an Indicator of Oxidative Stress, and the Cardio-Ankle Vascular Index in Hypertensive Patients

Cited by 19 publications

References 30 publications

Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus

Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus

Elevated Arterial Stiffness and Diastolic Dysfunction in Subclinical Hypothyroidism

Cardiorespiratory Fitness is a Strong Predictor of the Cardio-ankle Vascular Index in Hypertensive Middle-aged and Elderly Japanese Men

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