Association between tumor necrosis factor-α -308 Gauss/A polymorphism and risk of silicosis and coal workers pneumoconiosis in Chinese population

Yang, Liteng; Liu, Xin; Wu, Guangyao; Chen, Lifang

doi:10.1080/08958378.2018.1494766

Cited by 7 publications

(5 citation statements)

References 15 publications

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“…It is worth noting that exposure to crystalline silica is prevalent among coal miners. 31 Recent studies in the United States, 3 China, 32 34 Several cohort studies reported the elevated prevalence of lung cancer and chronic cardiopulmonary obstructive diseases among coal miners. 35 In earlier studies, based on the NHIS data, we found significantly increased odds of chronic diseases including hypertension, heart disease, and diabetes among ex-miners.…”

Section: Discussionmentioning

confidence: 99%

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Estimating mortality from coal workers' pneumoconiosis among Medicare beneficiaries with pneumoconiosis using binary regressions for spatially sparse data

Paul

Adeyemi

2022

American J Industrial Med

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Background: Coal workers' pneumoconiosis (CWP) is an occupational lung disease due to inhalation of coal dust. We estimated mortality from CWP and other pneumoconioses among Medicare beneficiaries.Methods: We used the 5% Medicare Limited Claims Data Set, 2011-2014, to identify patients diagnosed with ICD-9-CM 500 (CWP) through 505 (Asbestosis, Pneumoconiosis due to other silica or silicates, Pneumoconiosis due to other inorganic dust, Pneumonopathy due to inhalation of other dust, and Pneumoconiosis, unspecified) codes. We applied binary regression models with spatial random effects to determine the association between CWP and mortality. Our inferences are based on Bayesian spatial hierarchical models, and model fitting was performed using Integrated Nested Laplace Approximation (INLA) algorithm in R/RStudio software. Results:The median age of the sample was 76 years. In a sample of 8531 Medicare beneficiaries, 2568 died. Medicare beneficiaries with CWP had 25% higher odds of death (adjusted OR: 1.25, 95% CI: 1.07, 1.46) than those with other types of pneumoconiosis. The number of comorbid conditions elevated the odds of death by 10% (adjusted OR: 1.10, 95% CI: 1.09, 1.10). Conclusion: CWP increases the likelihood of death among Medicare beneficiaries.Healthcare professionals should make concerted efforts to monitor patients with CWP to prevent premature mortality.

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Section: Discussionmentioning

confidence: 99%

“…It is worth noting that exposure to crystalline silica is prevalent among coal miners. 31 Recent studies in the United States, 3 China, 32 and Australia 33 highlighted the coexistence of silicosis and CWP among coal miners, underscoring the need for continuous surveillance of respirable silica dust exposure levels among coal miners.…”

Section: Discussionmentioning

confidence: 99%

Estimating mortality from coal workers' pneumoconiosis among Medicare beneficiaries with pneumoconiosis using binary regressions for spatially sparse data

Paul

Adeyemi

2022

American J Industrial Med

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“… 20 It has been reported that it may be due to the genetic factors that play an indispensable role in the occurrence and development of COPD. 21 With the development of molecular biology, many genetic polymorphisms associated with lung function have been reported, such as HLA-DQB1-rs9273410, 22 TNF-A gene-308 G/A polymorphism, 23 ADRB2-rs12654778 24 and SREK1-rs74794265. 25 However, limited by race and sample size, only a small proportion of the population’s susceptibility to COPD can be explained.…”

Section: Discussionmentioning

confidence: 99%

Role of Genetic Polymorphisms in IL12Rβ2 in Chronic Obstructive Pulmonary Disease

Fu¹,

Liu²,

Wu³

2022

COPD

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Background: Chronic obstructive pulmonary disease (COPD) is the most common chronic inflammatory airway disease. Il-12r beta 2 (IL-12Rβ2) is important for the production of pathogenic Th1 cells. We aimed to explore the association between IL-12Rβ2 genetic variants and COPD risk among southern Chinese Han population. Methods: We recruited 996 participants to perform an association analysis through SNPStats online software. We used false-positive report probability analysis to detect whether the positive findings were noteworthy. Haploview 4.2 software and SNPStats were used to conduct the haplotype analysis and linkage disequilibrium. Finally, the interaction of SNP-SNP in COPD risk was evaluated by multifactor dimensionality reduction. Results:The study found evidence that genetic loci in IL-12Rβ2 (rs2201584, rs1874791, rs6679356, and rs3790567) were potentially associated with the COPD susceptibility. In particular, IL-12Rβ2-rs2201584 and -rs1874791 showed close associations with COPD risk in both overall and several stratified analyses. Overall analysis or several stratified analyses indicated that allele A or homozygous genotype AA of IL-12Rβ2-rs2201584 were risk factors for COPD (Allele A: OR (95% CI) = 1.23 (1.02-1.48), p = 0.033; genotype AA: OR (95% CI) = 1.76 (1.15-2.69), p = 0.009). The allele A or homozygous genotype AA of IL-12Rβ2-rs1874791 were also risk factors for COPD (Allele A: OR (95% CI) = 1.36 (1.10-1.68), p = 0.004; genotype AA: OR (95% CI) = 2.17 (1.18-3.99), p = 0.013). Conclusion: Intronic variants in IL-12Rβ2 (rs2201584, rs1874791, rs6679356, and rs3790567) were associated with the COPD susceptibility. In particular, there were sufficient evidences that IL-12Rβ2-rs2201584 and -rs1874791 were associated with the increasing risk of COPD.

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“…TNF-α and IL-6 are a proinflammatory cytokines, important in the onset of inflammation, development, and progression of pulmonary fibrosis, and associated with the progression of pneumoconiosis in inflammation caused by mine dusts. Papers indicate that the high levels of pro-inflammatory cytokines such as TNF-α and others is an increased risk of pneumoconiosis progression in mine workers, even in retired years (20)(21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

Kömür madeni ortamında tutulan sıçanlarda akciğer toksisitesinin in vivo solunum kayıtları ile değerlendirilmesi: Deneysel Bir Çalışma

Çam

Arslan

2019

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi

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OBJECTIVE: Mine workers exposed to dusts or toxic gasses in occupational atmospheric conditions. Pneumoconiosis and other lung diseases are charecterized by the pathogenesis of coal dust-caused pulmonary toxicity associated with reactive oxygen species (ROS). MATERIALS AND METHODS:This study was conducted to investigate the respiration failures and fibrosis in rats after being exposed to coal dust and gases in mine atmosphere. Another aim was to study the therapeutic effect of erdosteine as antioxidant therapy. Rats were exposed to mine ambience for four week, and then they were breathed in the clean air for four week. The respiratory functions of rats were recorded once a week for eight week, as in vivo. The fibrosis of lung tissue levels, the oxidant/antioxidant status, and cytokines of inflammation in bronchoalveolar lavage fluids (BALFs) were evaluated, at the end of the processes. RESULTS: We observed to be the beginning of respiratory abnormalities in animals exposed to coal dust in second week. The end of fourth week, there were the increase of respiratory frequency and along with the decrease of respiratory depth. The respiratory failures were not improved in clean ambience, moreover apnea were appearance in the end of six week (the second week of clean air). Deaths were 28% in animals. Erdosteine administer to rats could not fully abolished to the pulmonary toxicity, however could able to hold to toxicity, and also there were not dies in rats administered to erdosteine. Coal dust exposure was resulted in fibrosis with higher hydroxyproline (HP) levels, cytokine inflammation with higher interleukin-6 (IL-6) and tumor necrosis factoralpha (TNF-α) levels, and lipid peroxidation with an increased malondialdehyde (MDA) levels, according to the healthy. A dramatically run out of endogen antidote sulfide pools (GSH), and an increased MPO activity were dedected in the mine dusts and gasses exposure group, according to the healthy animals. High biochemical index of toxicity were partly balanced by erdosteine. CONCLUSIONS: Our experimental findings support the hypothesis that ROS is induced coal workers' pneumoconiosis. Re-oxygenation cannot be getting it together to reverse the pulmonary toxicity. On the top of it, it can make its pathogenesis further exaggerating and even worse. On this account we heartily speculate that reoxygenation should be by steps in mine workers. In addition the antioxidant therapy may be partly a choice be able to tolerate the coal dust-induced lung toxicity of mine workers. Çam ve Arslan. AU Sağlık Bil. Derg. Sayfa 1501 Kömür madeni ortamında tutulan sıçanlarda akciğer toksisitesinin in vivo solunum kayıtları ile değerlendirilmesi: Deneysel bir çalışma Amaç: Maden işçileri çalışma ortamı koşullarında tozlara veya zehirli gazlara maruz kalmaktadır. Pnömokonyoz ve diğer akciğer hastalıkları, kömür tozu kaynaklı pulmoner toksisitenin reaktif oksijen türleriyle (ROS) ilişkili patogenezi ile karakterizedir. Yöntem: Bu çalışma, maden atmosferinde kömür tozu ve gazlarına maruz kaldıktan sonra ...

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Association between tumor necrosis factor-α -308 Gauss/A polymorphism and risk of silicosis and coal workers pneumoconiosis in Chinese population

Cited by 7 publications

References 15 publications

Estimating mortality from coal workers' pneumoconiosis among Medicare beneficiaries with pneumoconiosis using binary regressions for spatially sparse data

Estimating mortality from coal workers' pneumoconiosis among Medicare beneficiaries with pneumoconiosis using binary regressions for spatially sparse data

Role of Genetic Polymorphisms in IL12Rβ2 in Chronic Obstructive Pulmonary Disease

Kömür madeni ortamında tutulan sıçanlarda akciğer toksisitesinin in vivo solunum kayıtları ile değerlendirilmesi: Deneysel Bir Çalışma

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