Association between TNF-α −308G&gt;A polymorphism and the development of acute coronary syndromes in Greek subjects: The CARDIO2000-GENE Study

Dedoussis, George; Panagiotakos, Demosthenes B.; Vidra, Nikoleta V.; Louizou, Eirini; Chrysοhoou, Christina; Germanos, Athanasios; Mantas, Yannis; Tokmakidis, Savvas P.; Pitsavos, Christos; Stefanadis, Christodoulos

doi:10.1097/01.gim.0000170993.75385.f4

Cited by 21 publications

(26 citation statements)

References 42 publications

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“…Although TNF*2 allele was previously shown to be associated with increased susceptibility to a variety of illnesses, 14-16,18-25 in this study TNF*1 allele was found to have a stronger association with CHD. Indeed, the findings are not consistent with those recently published by other authors where an association was found to be in favour of TNF*2 allele for Greek patients (n = 237) with acute coronary syndromes 26 and strong family history of CHD. In contrast, studies by Allen et al 9 failed to demonstrate a significant difference in TNF-␣ allele distribution between healthy volunteers and patients with coronary artery disease (CAD) from the Northwest Region of UK.…”

Section: Discussioncontrasting

confidence: 77%

“…It is not clear why the results from the latter two studies although in agreement in terms of genotype distribution, markedly differ with respect to the association between allelic distribution and CAD prevalence and severity. In addition, the results from the latter two studies markedly contrast with the findings by Dedoussis et al 26 where a strong association with TNF*2 allele was shown for acute coronary syndromes. This may suggest the likelihood that the allelic association of TNF-␣ gene with CHD may be heavily influenced by other factors such as environmental conditions, dietary composition and ethnicity, clearly a hypothesis that requires further investigation.…”

Section: Discussioncontrasting

confidence: 73%

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A variant of position −308 of the Tumour necrosis factor alpha gene promoter and the risk of coronary heart disease

Elahi

Gilmour

Matata

et al. 2008

Heart, Lung and Circulation

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Section: Discussioncontrasting

confidence: 77%

Section: Discussioncontrasting

confidence: 73%

A variant of position −308 of the Tumour necrosis factor alpha gene promoter and the risk of coronary heart disease

Elahi

Gilmour

Matata

et al. 2008

Heart, Lung and Circulation

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“…The TNF-a )308G > A polymorphism has been associated with increased susceptibility to several diseases where inflammation plays a predominant role and carriers of the minor allele may be at increased risk of CHD [11]. A recent meta-analysis performed to assess the association of the TNF-a )308G > A polymorphism with the components of the metabolic syndrome demonstrated that individuals who carried the )308A variant were at higher risk of developing obesity compared with non-carriers, and had significantly higher systolic arterial blood pressure and plasma insulin levels [33].…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, a number of candidate gene polymorphisms have been identified, on the basis of their presumed physiologic or pathophysiologic role and limited, but growing, empirical evidence [4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

A direct assessment of genetic contribution to the incidence of coronary infarct in the general population Greek EPIC cohort

et al. 2006

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To estimate the fraction of the incidence of coronary infarct attributable to the combined action of common genetic polymorphisms likely to be related to this condition, we conducted a case-control study nested within the Greek component of the European Prospective Investigation into Cancer and Nutrition. A total of 202 cases with a new, medically confirmed coronary infarct and 197 controls who had not developed an infarct by the time the corresponding case was diagnosed, were identified. A simple a priori score, relying on a total of 11 genetic polymorphisms was developed. Each polymorphism contributed 1 unit if the subject was homozygous for the high-risk allele, 0.5 units if the subject was heterozygous and 0 units if the subject was homozygous for the low-risk allele. Cases were over-represented in the presumed high genetic risk score values (chi square for trend = 10.18; p = 0.0014). The odds ratio to develop coronary infarct was 1.55 (95% confidence interval: 1.02-2.37) for score > or = 3.0, and 2.02 (1.31-3.11) for score > or = 3.5. In both instances the population fraction of the disease attributable to genetic predisposition exceeded 22%. Assuming a prior probability of at least 0.10 for the score to be predictive of coronary infarct risk, our findings are more likely than not to be truly positive. Our results, based on a simple score integrating the additive impact of 11 genetic polymorphisms, indicate that genetic predisposition accounts for a considerable fraction of the incidence of coronary infarct in the community.

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“…Both environmental and life style factors contribute strongly to this [13] . However, genetic variation also plays a key role in the likelihood of having acute coronary syndromes (ACS) [14] .…”

mentioning

confidence: 99%

Cholesteryl Ester-Transfer Protein (CETP) Polymorphism and the Association of Acute Coronary Syndromes by Obesity Status in Greek Subjects: The CARDIO2000-GENE Study

Dedoussis

Panagiotakos²,

Louizou³

et al. 2007

Hum Hered

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Objective: Cholesterol ester transfer protein (CETP) regulates plasma lipid distribution. The present study aimed to investigate whether the CETP gene (Taq1B) polymorphism predisposes to Acute Coronary Syndromes (ACS) depending on obesity status. Methods: We studied demographic, lifestyle and clinical information in 237 hospitalized patients (185 males) with a first event of an ACS and 237 controls matched by age and sex. CETP Taq1B genotyping was performed by PCR-RFLP analysis. Results: Overall, the CETP genotype frequencies were, in patients: 14% (n = 33), 35% (n = 83) and 51% (n = 121) and in controls: 17% (n = 39), 33% (n = 78) and 50% (n = 120) for B2B2, B1B1 and B1B2 respectively (p = 0.72). A significant interaction (p for interaction <0.001) was observed between obesity status and CETP concerning the likelihood of having ACS. Therefore, we stratified our analysis by obesity status and observed that B2B2 was associated with a 0.27 times lower likelihood of having ACS among normal-weight people (OR = 0.27, p = 0.02). No significant relationships were observed among overweight or obese participants. Conclusions: These findings provide evidence of a protective effect of the B2B2 genotype of the CETP Taq1B polymorphism on the likelihood of having a first event of ACS in normal-weight persons.

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Association between TNF-α −308G>A polymorphism and the development of acute coronary syndromes in Greek subjects: The CARDIO2000-GENE Study

Cited by 21 publications

References 42 publications

A variant of position −308 of the Tumour necrosis factor alpha gene promoter and the risk of coronary heart disease

A variant of position −308 of the Tumour necrosis factor alpha gene promoter and the risk of coronary heart disease

A direct assessment of genetic contribution to the incidence of coronary infarct in the general population Greek EPIC cohort

Cholesteryl Ester-Transfer Protein (CETP) Polymorphism and the Association of Acute Coronary Syndromes by Obesity Status in Greek Subjects: The CARDIO2000-GENE Study

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